The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652 · see citing works

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157 · see citing works

Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

Hawley, S. A., Davison, M., Woods, A., Davies, S. P., Beri, R. K., Carling, D., & Hardie, D. G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27879 · Cited by 1,264 · see citing works

5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?

Corton, J. M., Gillespie, J. G., Hawley, S. A., & Hardie, D. G. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20498.x · Cited by 1,232 · see citing works

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

Winder, W. W., & Hardie, D. G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e1 · Cited by 1,000 · see citing works

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00251-9 · Cited by 924 · see citing works

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise

Winder, W. W., & Hardie, D. G. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.2.e299 · Cited by 799 · see citing works

AMP‐activated protein kinase: the energy charge hypothesis revisited

Hardie, D. G., & Hawley, S. A. (2001) · BioEssays · doi:10.1002/bies.10009 · Cited by 784 · see citing works

5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.

Kurth-Kraczek, E. J., Hirshman, M. F., Goodyear, L. J., & Winder, W. W. (1999) · Diabetes · doi:10.2337/diabetes.48.8.1667 · Cited by 715 · see citing works

Clinical Pharmacokinetics of Metformin

Scheen, A. J. (1996) · Clinical Pharmacokinetics · doi:10.2165/00003088-199630050-00003 · Cited by 640 · see citing works

5′‐AMP inhibits dephosphorylation, as well as promoting phosphorylation, of the AMP‐activated protein kinase. Studies using bacterially expressed human protein phosphatase‐2C <i>α</i> and native bovine protein phosphatase‐2A _c

(1995) · FEBS Letters · doi:10.1016/0014-5793(95)01368-7 · Cited by 595 · see citing works

Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinase

Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D., & Beri, R. K. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01006-4 · Cited by 488 · see citing works

Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus

Cusi, K. J., Consoli, A., & DeFronzo, R. A. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.11.8923861 · Cited by 456 · see citing works

5′-AMP Activates the AMP-activated Protein Kinase Cascade, and Ca2+/Calmodulin Activates the Calmodulin-dependent Protein Kinase I Cascade, via Three Independent Mechanisms

Hawley, S. A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., & Hardie, D. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.27186 · Cited by 441 · see citing works

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

Lochhead, P. A., Salt, I. P., Walker, K. S., Hardie, D. G., & Sutherland, C. D. (2000) · Diabetes · doi:10.2337/diabetes.49.6.896 · Cited by 391 · see citing works

The blooming of the French lilac

Witters, L. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14178 · Cited by 370 · see citing works

AMP-Activated Protein Kinase: An Ultrasensitive System for Monitoring Cellular Energy Charge

HARDIE, D. G., SALT, I. P., HAWLEY, S. A., & DAVIES, S. P. (1999) · Biochemical Journal · doi:10.1042/bj3380717 · Cited by 362 · see citing works

Effect of AMPK activation on muscle glucose metabolism in conscious rats

Bergeron, R., Russell, R. R., Young, L. H., Ren, J., Marcucci, M., Lee, A., & Shulman, G. I. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.5.e938 · Cited by 301 · see citing works

Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase

Zheng, D., MacLean, P. S., Pohnert, S. C., Knight, J. B., Olson, A. L., Winder, W. W., & Dohm, G. L. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1073 · Cited by 292 · see citing works

The α1 and α2 isoforms of the AMP‐activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

Woods, A., Salt, I. P., Scott, J., Hardie, D. G., & Carling, D. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01209-4 · Cited by 261 · see citing works

Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase

Henin, N., Vincent, M. F., Gruber, H. E., & Berghe, G. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.7.7737463 · Cited by 251 · see citing works

Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells

Hundal, H. S., Ramlal, T., Reyes, R., Leiter, L. A., & Klip, A. (1992) · Endocrinology · doi:10.1210/endo.131.3.1505458 · Cited by 243 · see citing works

Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes

Vincent, M., Marangos, P. J., Gruber, H. E., & Berghe, G. (1991) · Diabetes · doi:10.2337/diab.40.10.1259 · Cited by 218 · see citing works

Regulation of spinach SNF1‐related (SnRK1) kinases by protein kinases and phosphatases is associated with phosphorylation of the T loop and is regulated by 5′‐AMP

Sugden, C., Crawford, R. M., Halford, N. G., & Hardie, D. G. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00532.x · Cited by 195 · see citing works

Chronic Treatment With 5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside Increases Insulin-Stimulated Glucose Uptake and GLUT4 Translocation in Rat Skeletal Muscles in a Fiber Type--Specific Manner

Buhl, E. S., Jessen, N., Schmitz, O., Pedersen, S. B., Pedersen, O. B., Holman, G. D., & Lund, S. A. (2001) · Diabetes · doi:10.2337/diabetes.50.1.12 · Cited by 182 · see citing works

Protein kinase substrate recognition studied using the recombinant catalytic domain of AMP-activated protein kinase and a model substrate

Scott, J. W., Norman, D., Hawley, S. A., Kontogiannis, L., & Hardie, D. G. (2002) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.5316 · Cited by 179 · see citing works

The dormancy‐related peroxiredoxin anti‐oxidant, PER1, is localized to the nucleus of barley embryo and aleurone cells

Stacy, R. A. P., Nordeng, T. W., Culiáñez‐Macià, F. A., et al. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00488.x · Cited by 171 · see citing works

Activation of glycogen phosphorylase and glycogenolysis in rat skeletal muscle by AICAR — an activator of AMP‐activated protein kinase

Young, M. E., Radda, G. K., & Leighton, B. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00129-9 · Cited by 146 · see citing works

Analysis of the Role of the AMP-Activated Protein Kinase in the Response to Cellular Stress

Hardie, D. G., Salt, I. P., & Davies, S. P. (2003) · Humana Press eBooks · doi:10.1385/1-59259-054-3:63 · Cited by 88 · see citing works

Results of a Placebo-Controlled Study of the Metabolic Effects of the Addition of Metformin to Sulfonylurea-Treated Patients: Evidence for a central role of adipose tissue

Abbasi, F., Kamath, V., Rizvi, A. A., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.12.1863 · Cited by 69 · see citing works

Metformin increases insulin-stimulated glucose transport in insulin-resistant human skeletal muscle.

Galuska, D., Zierath, J. R., Thörne, A., SONNENFELD, T., & Wallberg‐Henriksson, H. (1991) · PubMed · Cited by 64 · see citing works

Metformin inhibits catecholamine‐stimulated lipolysis in obese, hyperinsulinemic, hypertensive subjects in subcutaneous adipose tissue: an in situ microdialysis study

Flechtner‐Mors, M., Ditschuneit, H. H. M., Jenkinson, C. P., et al. (1999) · Diabetic Medicine · doi:10.1046/j.1464-5491.1999.00189.x · Cited by 26 · see citing works

Studies on Chinese hamster ovary mutants showing multiple cross-resistance to oxidative phosphorylation inhibitors

Lagarde, A. E., & Siminovitch, L. (1979) · Somatic Cell and Molecular Genetics · doi:10.1007/bf01542646 · Cited by 14 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

Kahn, B. B., Alquier, T., Carling, D., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2004.12.003 · Cited by 2,799 · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Hawley, S. A., Pan, D. A., Mustard, K. J., Ross, L., Bain, J., Edelman, A. M., Frenguelli, B. G., & Hardie, D. G. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.009 · Cited by 1,589 · see citing works

Metformin: An Old Drug for the Treatment of Diabetes But a New Drug for the Protection of the Endothelium

Kinaan, M., Ding, H., & Triggle, C. R. (2015) · Medical Principles and Practice · doi:10.1159/000381643 · Cited by 1,515 · see citing works

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

Lizcano, J. M., Göransson, O., Toth, R., Deak, M., Morrice, N. A., Boudeau, J., Hawley, S. A., Udd, L., Mäkelä, T. P., Hardie, D. G., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600110 · Cited by 1,381 · see citing works

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Madiraju, A. K., Erion, D. M., Rahimi, Y., Zhang, X.-M., Braddock, D. T., Albright, R. A., Prigaro, B. J., Wood, J. L., Bhanot, S., MacDonald, M. J., et al. (2014) · Nature · doi:10.1038/nature13270 · Cited by 1,284 · see citing works

Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States

Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J.-M., Lee, C. H., Oh, W. K., Kim, C. T., et al. (2006) · Diabetes · doi:10.2337/db06-0006 · Cited by 1,054 · see citing works

Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status

Hardie, D. G. (2003) · Endocrinology · doi:10.1210/en.2003-0982 · Cited by 994 · see citing works

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Sahra, I. B., Laurent, K., Loubat, A., Giorgetti-Peraldi, S., Colosetti, P., Auberger, P., Tanti, J. F., Le Marchand-Brustel, Y., & Bost, F. (2008) · Oncogene · doi:10.1038/sj.onc.1211024 · Cited by 861 · see citing works

Cellular and Molecular Mechanisms of Metformin Action

LaMoia, T. E., & Shulman, G. I. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa023 · Cited by 791 · see citing works

Benefits of Metformin in Attenuating the Hallmarks of Aging

Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766 · see citing works

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773 · see citing works

CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations

Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G., & Hardie, D. G. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19874 · Cited by 754 · see citing works

Metformin Induces a Dietary Restriction-Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1 and SKN-1

Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671 · see citing works

Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle

Jørgensen, S. B., Viollet, B., Andreelli, F., Frøsig, C., Birk, J. B., Schjerling, P., Vaulont, S., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306205200 · Cited by 553 · see citing works

Effects of rosiglitazone and metformin on liver fat content, hepatic insulin resistance, insulin clearance, and gene expression in adipose tissue in patients with type 2 diabetes

Tiikkainen, M., Häkkinen, A.-M., Korsheninnikova, E., Nyman, T., Mäkimattila, S., & Yki-Järvinen, H. (2004) · Diabetes · doi:10.2337/diabetes.53.8.2169 · Cited by 524 · see citing works

Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro

Alimova, I. N., Liu, B., Fan, Z., Edgerton, S. M., Dillon, T., Lind, S. E., & Thor, A. D. (2009) · Cell Cycle · doi:10.4161/cc.8.6.7933 · Cited by 523 · see citing works

Thiazolidinediones, Like Metformin, Inhibit Respiratory Complex I

Brunmair, B., Staniek, K., Gras, F., Scharf, N., Althaym, A., Clara, R., Roden, M., Gnaiger, E., Nohl, H., Waldhäusl, W., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1052 · Cited by 521 · see citing works

The role of AMP-activated protein kinase in the action of ethanol in the liver

You, M., Matsumoto, M., Pacold, C. M., Cho, W. K., & Crabb, D. W. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.09.049 · Cited by 469 · see citing works

AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, N., & Prentki, M. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1344 · Cited by 451 · see citing works

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

Wang, Y., An, H., Liu, T., Qin, C., Sesaki, H., Guo, S., Radovick, S., Hussain, M., Maheshwari, A., Wondisford, F. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.070 · Cited by 432 · see citing works

Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin

Hsu, C.-C., Wahlqvist, M. L., Lee, M.-S., & Tsai, H.-N. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101524 · Cited by 372 · see citing works

AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity.

O’Neill, H. M., Holloway, G. P., & Steinberg, G. R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.06.019 · Cited by 364 · see citing works

Regulation of 5′AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle

Wojtaszewski, J. F. P., MacDonald, C., Nielsen, J. N., Hellsten, Y., Hardie, D. G., Kemp, B. E., Kiens, B., & Richter, E. A. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00436.2002 · Cited by 348 · see citing works

Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333 · see citing works

Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte

Chan, A. Y. M., Soltys, C.-L. M., Young, M. E., Proud, C. G., & Dyck, J. R. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403528200 · Cited by 331 · see citing works

Drug repurposing in cancer

Sleire, L., Førde, H. E., Netland, I. A., Leiss, L., Skeie, B. S., & Enger, P. Ø. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.07.013 · Cited by 329 · see citing works

Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H., & Sakamoto, K. (2018) · Nature Medicine · doi:10.1038/s41591-018-0159-7 · Cited by 313 · see citing works

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR

Sakamoto, K., Göransson, O., Hardie, D. G., & Alessi, D. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00074.2004 · Cited by 299 · see citing works

AMPK, Mitochondrial Function, and Cardiovascular Disease

Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works

Repurposing metformin: an old drug with new tricks in its binding pockets

Pryor, R., & Cabreiro, F. (2015) · Biochemical Journal · doi:10.1042/bj20150497 · Cited by 280 · see citing works

Metformin Activates AMP-Activated Protein Kinase in Primary Human Hepatocytes by Decreasing Cellular Energy Status

Stephenne, X., Foretz, M., Taleux, N., van der Zon, G. C., Sokal, E., Hue, L., Viollet, B., & Guigas, B. (2011) · Diabetologia · doi:10.1007/s00125-011-2311-5 · Cited by 287 · see citing works

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

Xie, Z., Dong, Y., Scholz, R., Neumann, D., & Zou, M.-H. (2008) · Circulation · doi:10.1161/circulationaha.107.744490 · Cited by 273 · see citing works

Minireview: Malonyl CoA, AMP-Activated Protein Kinase, and Adiposity

Ruderman, N. B., Saha, A. K., & Kraegen, E. W. (2003) · Endocrinology · doi:10.1210/en.2003-0849 · Cited by 266 · see citing works

Metformin Prevents High-Glucose–Induced Endothelial Cell Death Through a Mitochondrial Permeability Transition-Dependent Process

Detaille, D., Guigas, B., Chauvin, C., Batandier, C., Fontaine, E., Wiernsperger, N., & Leverve, X. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2179 · Cited by 263 · see citing works

Metformin Effects on the Heart and the Cardiovascular System: A Review of Experimental and Clinical Data

Nesti, L., & Natali, A. (2017) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2017.04.009 · Cited by 211 · see citing works

Sarcopenic obesity: Emerging mechanisms and therapeutic potential

Axelrod, C. L., Dantas, W. S., & Kirwan, J. P. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155639 · Cited by 204 · see citing works

Metformin: A Hopeful Promise in Aging Research

Novelle, M. G., Ali, A., Diéguez, C., Bernier, M., & de Cabo, R. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025932 · Cited by 178 · see citing works

Age-related hyperinsulinemia leads to insulin resistance in neurons and cell-cycle-induced senescence

Chow, H.-M., Shi, M., Cheng, A., Gao, Y., Chen, G., Song, X., So, R. W. L., Zhang, J., & Herrup, K. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0505-1 · Cited by 171 · see citing works

Quercetin, a Lead Compound against Type 2 Diabetes Ameliorates Glucose Uptake via AMPK Pathway in Skeletal Muscle Cell Line

Dhanya, R., Arya, A. D., Nisha, P., & Jayamurthy, P. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00336 · Cited by 167 · see citing works

5′-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle

Frøsig, C., Jørgensen, S. B., Hardie, D. G., Richter, E. A., & Wojtaszewski, J. F. P. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00317.2003 · Cited by 161 · see citing works

Metformin alters DNA methylation genome-wide via the H19/SAHH axis

Zhong, T., Men, Y., Lu, L., Geng, T., Zhou, J., Mitsuhashi, A., Shozu, M., Maihle, N. J., Carmichael, G. G., Taylor, H. S., et al. (2017) · Oncogene · doi:10.1038/onc.2016.391 · Cited by 151 · see citing works

The differential effects of metformin on markers of endothelial activation and inflammation in subjects with impaired glucose tolerance: A placebo-controlled, randomized clinical trial

Caballero, A. E., Delgado, A., Aguilar-Salinas, C. A., Herrera, A. N., Castillo, J. L., Cabrera, T., Gomez-Perez, F. J., & Rull, J. A. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-0019 · Cited by 151 · see citing works

Phytotherapy in diabetes: Review on potential mechanistic perspectives

El-Abhar, H. S., & Schaalan, M. F. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i2.176 · Cited by 145 · see citing works

Metformin Activates AMP-Activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex

Meng, S., Cao, J., He, Q., Xiong, L., Chang, E., Radovick, S., Wondisford, F. E., & He, L. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.604421 · Cited by 146 · see citing works

Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy

Barini, E., Antico, O., Zhao, Y., Asta, F., Tucci, V., Catelani, T., Marotta, R., Xu, H., & Gasparini, L. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0082-7 · Cited by 126 · see citing works

Understanding the variation in exercise responses to guide personalized physical activity prescriptions

Noone, J., Mucinski, J. M., DeLany, J. P., Sparks, L. M., & Goodpaster, B. H. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.025 · Cited by 128 · see citing works

Resistance training to improve type 2 diabetes: working toward a prescription for the future

Pesta, D. H., Goncalves, R. L. S., Madiraju, A. K., Strasser, B., & Sparks, L. M. (2017) · Nutrition &amp; Metabolism · doi:10.1186/s12986-017-0173-7 · Cited by 120 · see citing works

Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats

Kane, D. A., Anderson, E. J., Price, J. W., Woodlief, T. L., Lin, C.-T., Bikman, B. T., Cortright, R. N., & Neufer, P. D. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.022 · Cited by 99 · see citing works

Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood

Salomäki, H., Vähätalo, L. H., Laurila, K., Jäppinen, N. T., Penttinen, A.-M., Ailanen, L., Ilyasizadeh, J., Pesonen, U., & Koulu, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056594 · Cited by 92 · see citing works

Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer

Samuel, S., Varghese, E., Kubatka, P., Triggle, C., & Büsselberg, D. (2019) · Biomolecules · doi:10.3390/biom9120846 · Cited by 81 · see citing works

LKB1 and AMPK and the regulation of skeletal muscle metabolism

Koh, H.-J., Brandauer, J., & Goodyear, L. J. (2008) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e3282fb7b76 · Cited by 78 · see citing works

AMPK is associated with the beneficial effects of antidiabetic agents on cardiovascular diseases

Lu, Q., Li, X., Liu, J., Sun, X., Rousselle, T., Ren, D., Tong, N., & Li, J. (2019) · Bioscience Reports · doi:10.1042/bsr20181995 · Cited by 69 · see citing works

Possible involvement of AMP-activated protein kinase in obesity resistance induced by respiratory uncoupling in white fat

Matejkova, O., Mustard, K. J., Sponarova, J., Flachs, P., Rossmeisl, M., Miksik, I., Thomason-Hughes, M., Grahame Hardie, D., & Kopecky, J. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.06.002 · Cited by 66 · see citing works

Prenatal metformin exposure in a maternal high fat diet mouse model alters the transcriptome and modifies the metabolic responses of the offspring

Salomäki, H., Heinäniemi, M., Vähätalo, L. H., Ailanen, L., Eerola, K., Ruohonen, S. T., Pesonen, U., & Koulu, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115778 · Cited by 63 · see citing works

AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6

Gongol, B., Marin, T., Peng, I.-C., Woo, B., Martin, M., King, S., Sun, W., Johnson, D. A., Chien, S., & Shyy, J. Y.-J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222051110 · Cited by 61 · see citing works

Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice

Kristensen, J. M., Larsen, S., Helge, J. W., Dela, F., & Wojtaszewski, J. F. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053533 · Cited by 48 · see citing works

Genetic and metabolic effects on skeletal muscle AMPK in young and older twins

Mortensen, B., Poulsen, P., Wegner, L., Stender-Petersen, K. L., Ribel-Madsen, R., Friedrichsen, M., Birk, J. B., Vaag, A., & Wojtaszewski, J. F. P. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00058.2009 · Cited by 36 · see citing works

Metformina e AMPK: um antigo fármaco e uma nova enzima no contexto da síndrome metabólica

Santomauro Jún, A. C., Ugolini, M. R., Santomauro, A. T., & Souto, R. P. D. (2008) · Arquivos Brasileiros de Endocrinologia &amp; Metabologia · doi:10.1590/s0004-27302008000100017 · Cited by 33 · see citing works

Metformin: Repurposing Opportunities for Cognitive and Mood Dysfunction

Ying, M., Maruschak, N., Mansur, R., Carvalho, A., Cha, D., & McIntyre, R. (2015) · CNS &amp; Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130205514 · Cited by 29 · see citing works

Association Between GLP1 RAs Use and Risk of Colorectal Cancer: A Systematic Review and Meta‐Analysis

Bushi, G., Gaidhane, S., Ballal, S., Kumar, S., Bhat, M., Sharma, S., Kumar, M. R., Sinha, A., Khatib, M. N., Rai, N., et al. (2025) · Health Science Reports · doi:10.1002/hsr2.70490 · Cited by 13 · see citing works

New findings in AMP-activated protein kinase

Feng-ha, G. (2014) · Chinese Heart Journal

Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

Scott, J. W., van Denderen, B. J. W., Jørgensen, S. B., Honeyman, J. E., Steinberg, G. R., Oakhill, J. S., Iseli, T. J., Koay, A. Z., Gooley, P. R., Stapleton, D., et al. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.10.005 · Cited by 252 · see citing works

Beneficial effects of metformin on primary cardiomyocytes via activation of adenosine monophosphate-activated protein kinase

Wang, Xiaofang, Zhang, et al. (2011) · 中华医学杂志：英文版

AMP‐activated protein kinase and cancer

Wang, W., & Guan, K. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01980.x · Cited by 163 · see citing works

돌외 추출물로부터 순수 분리된 saponin 계열의 화합물인 Damulin B에 의한 AMP-activated protein kinase (AMPK)의 활성화 기작에 대한 연구

정시성 (2011)