The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Heritability of Plasma Sex Hormones and Hormone Binding Globulin in Adult Male Twins
Abstract
Plasma sex hormone concentrations have been used as biomarkers in epidemiological studies of many conditions including cancer, obesity, bone density, and coronary heart disease. The objective of this analysis was to estimate genetic and nongenetic influences on endogenous sex hormones (testosterone, estradiol, estrone, and SHBG) in a large sample of 532 adult white male twins (134 monozygotic and 132 dizygotic twin pairs) from the National Heart, Lung, and Blood Institute Twin Study. Participants were aged 59-70 yr at the time of plasma collection, and hormone concentrations were determined with RIA. Genetic models were fitted by the method of maximum likelihood. Testosterone and SHBG concentrations have substantial genetic variation, with additive genetic factors accounting for 57 and 68% of the total phenotypic variation, respectively. In contrast, variation in estrone (37% shared environmental and 63% individual specific environmental effects) and estradiol concentrations (25% genetic effect, 44% shared environmental effects, and 31% individual specific environmental effects) were largely influenced by nongenetic factors. Assessment of the relative contribution of genetic and nongenetic influences on hormone concentrations may help in the search for genes underlying variation and covariation in complex traits affected by plasma sex hormone concentrations.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“With adjustment for age and body-mass index, T levels were 16% higher in men living in Hong Kong and Japan, while Asian men living in the US were found to have similar levels to other US residents. No differences were noted in T levels based on ethnicity alone.”
From Challenges in Testosterone Measurement, Data Interpretation, and Methodological Appraisal of Interventional Trials (2016) · cites this paper as [52]
Citations
Cites
Akaike, H. (1987) · Psychometrika · doi:10.1007/bf02294359 · Cited by 5,264
Akaike, H. (1987) · Springer Series in Statistics · doi:10.1007/978-1-4612-1694-0_29 · Cited by 4,027
Sex Steroids and the Construction and Conservation of the Adult Skeleton
Riggs, B. L., Khosla, S., & Melton, L. J. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.3.0465 · Cited by 1,846
Classical twin studies and beyond
Boomsma, D., Busjahn, A., & Peltonen, L. (2002) · Nature Reviews Genetics · doi:10.1038/nrg932 · Cited by 1,105
Gray, A., Feldman, H. A., McKinlay, J. B., & Longcope, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-5-1016 · Cited by 1,104
Endogenous Hormones and Breast Cancer Risk
Bernstein, L., & Ross, R. K. (1993) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036116 · Cited by 697
A twin-pronged attack on complex traits
Martin, N. G., Boomsma, D. I., & Machin, G. A. (1997) · Nature Genetics · doi:10.1038/ng1297-387 · Cited by 654
THE NHLBI TWIN STUDY OF CARDIOVASCULAR DISEASE RISK FACTORS: METHODOLOGY AND SUMMARY OF RESULTS
Feinleib, M., Garrison, R. J., Fabsitz, R. R., Christian, J. C., Hrubec, Z., Borhani, N. O., Kannel, W. B., Rosenman, R. H., Schwartz, J. T., & Wagner, J. O. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112464 · Cited by 449
Low serum testosterone and sex-hormone-binding-globulin in massively obese men
GLASS, A. R., SWERDLOFF, R. S., BRAY, G. A., DAHMS, W. T., & ATKINSON, R. L. (1977) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-45-6-1211 · Cited by 430
Polymorphisms Associated With Circulating Sex Hormone Levels in Postmenopausal Women
Dunning, A. M., Dowsett, M., Healey, C. S., Tee, L. J., Luben, R., Folkerd, E. J., Novik, K. L., Kelemen, L., Ogata, S., Pharoah, P. D. P., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh167 · Cited by 346
Cited by
Sorted by citations
Items 101–117 of 117
Mansour, A. A. (2018) · Endocrinology&Metabolism International Journal · doi:10.15406/emij.2018.06.00153 · Cited by 1
Sato, Y., Tajima, A., Katsurayama, M., Nozawa, S., Yoshiike, M., Koh, E., Kanaya, J., Namiki, M., Matsumiya, K., Tsujimura, A., et al. (2017) · Human Reproduction Open · doi:10.1093/hropen/hox005 · Cited by 1
Sex steroid metabolism and body composition
Swanson, C. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
COMT Genotype, sex steroids, and bone phenotype in mice and men
Eriksson, A. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Wonkam, A. (2011) · Journal of Genetic Counseling · doi:10.1007/s10897-011-9369-6
RetractedGENETICS OF ANDROGEN DISPOSITION
Schulze, J. J. (2007)
Schmitt, D. P. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511781193.021
Cauley, J. A. (2009) · Springer eBooks · doi:10.1007/978-1-84628-697-1_4
Meikle, A. W. (2006) · Yearbook of Endocrinology · doi:10.1016/s0084-3741(08)70457-8
de Jong, B. (2013)
Phenotypically Enriched Genotypic Imputation in Genetic Association Tests
Zhuang, W. V., Murabito, J. M., & Lunetta, K. L. (2016) · Human Heredity · doi:10.1159/000446986
Braunstein, G. D., & SHUFELT, C. L. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1165337.628296
Travis, R. C., Schumacher, F. R., Hirschhorn, J. N., Kraft, P., Allen, N. E., Albanes, D., Berglund, G. L., Berndt, S. I., Boeing, H., Bueno-de-Mesquita, H. B., et al. (2023) · doi:10.1158/1055-9965.c.6514777
Travis, R. C., Schumacher, F. R., Hirschhorn, J. N., Kraft, P., Allen, N. E., Albanes, D., Berglund, G. L., Berndt, S. I., Boeing, H., Bueno-de-Mesquita, H. B., et al. (2023) · doi:10.1158/1055-9965.c.6514777.v1
Evolutionary behavioral endocrinology: Introduction to the special issue
Vitousek, M. N., Dantzer, B., Fuxjager, M. J., & Schlinger, B. A. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105356
Systemic Onco-sphere: An Overview from the Host’s Perspective
Saw, P. E., & Song, E. (2023) · Springer eBooks · doi:10.1007/978-981-99-1183-7_18
Role of bone microarchitecture and hereditary determinants of bone fragility
Nagy, H. A. A. M. (2013) · theses.fr (ABES) · doi:10.70675/950dc642z816dz4693za1e6za963d3d33fff
Metadata
- Authors
- Ring, H. Z., Lessov, C. N., Reed, T., Marcus, R., Holloway, L., Swan, G. E., & Carmelli, D.
- Affiliations
- SRI International (US)
- Indiana University Indianapolis (US)
- VA Palo Alto Health Care System (US)
- Corresponding author
- Ring, Huijun Z.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-06-01
- Volume
- 90
- Issue
- 6
- Pages
- 3653-3658
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2131643226
- Cited by
- 117
- References
- 56
- Citations by year
- 2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 8
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 51429, R01HL051429)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- heritability, plasma sex hormones, testosterone, estradiol, estrone, sex hormone-binding globulin, monozygotic twins, dizygotic twins, additive genetic effects, shared environmental effects, adult male, genetic epidemiology
- MeSH terms
- Aged, Estradiol, Estrone, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Twins, Dizygotic, Twins, Monozygotic, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
