Cited by 117Genetic Associations and EpidemiologyHormonal and reproductive studiesSexual Differentiation and Disorders

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Heritability of Plasma Sex Hormones and Hormone Binding Globulin in Adult Male Twins

Ring, Huijun Z., Lessov, Christina N., Reed, Terry, Marcus, Robert, Holloway, Leah, Swan, Gary E., Carmelli, Dorit·2005·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2004-1025

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Abstract

Plasma sex hormone concentrations have been used as biomarkers in epidemiological studies of many conditions including cancer, obesity, bone density, and coronary heart disease. The objective of this analysis was to estimate genetic and nongenetic influences on endogenous sex hormones (testosterone, estradiol, estrone, and SHBG) in a large sample of 532 adult white male twins (134 monozygotic and 132 dizygotic twin pairs) from the National Heart, Lung, and Blood Institute Twin Study. Participants were aged 59-70 yr at the time of plasma collection, and hormone concentrations were determined with RIA. Genetic models were fitted by the method of maximum likelihood. Testosterone and SHBG concentrations have substantial genetic variation, with additive genetic factors accounting for 57 and 68% of the total phenotypic variation, respectively. In contrast, variation in estrone (37% shared environmental and 63% individual specific environmental effects) and estradiol concentrations (25% genetic effect, 44% shared environmental effects, and 31% individual specific environmental effects) were largely influenced by nongenetic factors. Assessment of the relative contribution of genetic and nongenetic influences on hormone concentrations may help in the search for genes underlying variation and covariation in complex traits affected by plasma sex hormone concentrations.

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Authors: Ring, H. Z., Lessov, C. N., Reed, T., Marcus, R., Holloway, L., Swan, G. E., & Carmelli, D.
Affiliations: SRI International (US)
Indiana University Indianapolis (US)
VA Palo Alto Health Care System (US)
Corresponding author: Ring, Huijun Z.
ORCID: Ring, Huijun Z.
Marcus, Robert
Swan, Gary E.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2005-06-01
Volume: 90
Issue: 6
Pages: 3653-3658
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2004-1025
OpenAlex: W2131643226
Cited by: 117
References: 56
Citations by year: 2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 8
FWCI: 4.82
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 51429, R01HL051429)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: heritability, plasma sex hormones, testosterone, estradiol, estrone, sex hormone-binding globulin, monozygotic twins, dizygotic twins, additive genetic effects, shared environmental effects, adult male, genetic epidemiology
MeSH terms: Aged, Estradiol, Estrone, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Twins, Dizygotic, Twins, Monozygotic, Body Mass Index

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Heritability of Plasma Sex Hormones and Hormone Binding Globulin in Adult Male Twins

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