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Cited by 117Genetic Associations and EpidemiologyHormonal and reproductive studiesSexual Differentiation and Disorders

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Heritability of Plasma Sex Hormones and Hormone Binding Globulin in Adult Male Twins

Ring, Huijun Z., Lessov, Christina N., Reed, Terry, Marcus, Robert, Holloway, Leah, Swan, Gary E., Carmelli, Dorit·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2004-1025
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Abstract

Plasma sex hormone concentrations have been used as biomarkers in epidemiological studies of many conditions including cancer, obesity, bone density, and coronary heart disease. The objective of this analysis was to estimate genetic and nongenetic influences on endogenous sex hormones (testosterone, estradiol, estrone, and SHBG) in a large sample of 532 adult white male twins (134 monozygotic and 132 dizygotic twin pairs) from the National Heart, Lung, and Blood Institute Twin Study. Participants were aged 59-70 yr at the time of plasma collection, and hormone concentrations were determined with RIA. Genetic models were fitted by the method of maximum likelihood. Testosterone and SHBG concentrations have substantial genetic variation, with additive genetic factors accounting for 57 and 68% of the total phenotypic variation, respectively. In contrast, variation in estrone (37% shared environmental and 63% individual specific environmental effects) and estradiol concentrations (25% genetic effect, 44% shared environmental effects, and 31% individual specific environmental effects) were largely influenced by nongenetic factors. Assessment of the relative contribution of genetic and nongenetic influences on hormone concentrations may help in the search for genes underlying variation and covariation in complex traits affected by plasma sex hormone concentrations.

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Metadata

Authors
Ring, H. Z., Lessov, C. N., Reed, T., Marcus, R., Holloway, L., Swan, G. E., & Carmelli, D.
Affiliations
  • SRI International (US)
  • Indiana University Indianapolis (US)
  • VA Palo Alto Health Care System (US)
Corresponding author
Ring, Huijun Z.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-06-01
Volume
90
Issue
6
Pages
3653-3658
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2004-1025
OpenAlex
W2131643226
Cited by
117
References
56
Citations by year
2024: 2 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 8
FWCI
4.82
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Heart, Lung, and Blood Institute (HL 51429, R01HL051429)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
heritability, plasma sex hormones, testosterone, estradiol, estrone, sex hormone-binding globulin, monozygotic twins, dizygotic twins, additive genetic effects, shared environmental effects, adult male, genetic epidemiology
MeSH terms
Aged, Estradiol, Estrone, Humans, Male, Middle Aged, Sex Hormone-Binding Globulin, Testosterone, Twins, Dizygotic, Twins, Monozygotic, Body Mass Index

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