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Cited by 28Hypothalamic control of reproductive hormonesSmoking Behavior and CessationPrenatal Substance Exposure Effects

Nicotine Inhibits Pulsatile Luteinizing Hormone Secretion in Human Males But Not in Human Females, and Tolerance to This Nicotine Effect Is Lost within One Week of Quitting Smoking

Funabashi, Toshiya, Sano, Akane, Mitsushima, Dai, Kimura, Fukuko·2005·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-0041
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Abstract

CONTEXT AND OBJECTIVE: Despite having increased knowledge of the adverse reproductive effects of smoking, it is unclear whether nicotine affects the pulsatile LH secretion in humans. We addressed this issue in male and female smokers and nonsmokers. SUBJECTS AND METHODS: Twenty-nine male and 16 female nonsmokers and smokers were recruited as volunteers. In male smokers, nicotine effect was also studied before and after quitting smoking. In females, cyclic ovulatory function was assessed by measuring basal body temperature, and sampling studies were performed during the follicular phase. In the morning of the sampling day, an iv catheter was inserted into an anterobrachial vein, and blood samples (1.0-1.5 ml each) were taken at 10-min intervals for 480 min, during which, at 240 min, nicotine was administered via a transdermal patch (Nicotinell transdermal therapeutic system) containing 17.5 mg nicotine. Plasma LH was measured by immunoradiometric assay kits. RESULTS: Nicotine significantly lengthened the interpulse interval of pulsatile LH secretion in male nonsmokers but not in female nonsmokers. In male smokers, nicotine did not lengthen the interpulse interval, and in female smokers it was also ineffective. After quitting cigarette smoking in male smokers, the refractory to nicotine effect disappeared within 1 wk. CONCLUSIONS: We conclude that nicotine inhibits pulsatile LH secretion only in males, and the tolerance developed to the nicotine effect disappears within 1 wk of quitting cigarette smoking. However, we cannot deny the possibility that nicotine effect would have been detected in females if more subjects had been studied.

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Authors
Funabashi, T., Sano, A., Mitsushima, D., & Kimura, F.
Affiliations
  • Yokohama City University (JP)
  • International University of Health and Welfare (JP)
Corresponding author
Kimura, Fukuko
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2005-07
Volume
90
Issue
7
Pages
3908-3913
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-0041
OpenAlex
W2105827221
Semantic Scholar
3299094788607a7d859baad6b307b44f4595a9f1
Cited by
28
References
46
Citations by year
2023: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 2
FWCI
1.34
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
Smoking Research Foundation
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Keywords
nicotine, luteinizing hormone, pulsatile LH secretion, smoking, sex differences, nicotine tolerance, smoking cessation, interpulse interval, nicotine patch, reproductive endocrinology, follicular phase
MeSH terms
Drug Tolerance, Female, gamma-Aminobutyric Acid, Humans, Luteinizing Hormone, Male, Nicotine, Sex Characteristics, Smoking, Testosterone

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