The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Epicardial Adipose Tissue and Insulin Resistance in Obese Subjects
Abstract
CONTEXT: Epicardial adipose tissue has been recently recognized as a source of bioactive molecules as well as free fatty acids, adiponectin, and inflammatory cytokines. Epicardial fat reflects intraabdominal visceral fat, and the echocardiographic assessment of this tissue is an easy and reliable marker of visceral adiposity. OBJECTIVE: In this study we evaluated whether epicardial adipose tissue is related to insulin sensitivity and glucose metabolism in obese subjects. PATIENTS: Thirty obese subjects (20 women and 10 men; mean age, 40.8 +/- 11.5 yr; body mass index, 43 +/- 9.1 kg/m2) were included in this study. No subject was taking drugs or had a history or evidence of metabolic, cardiovascular, respiratory, or hepatic disease. MAIN OUTCOME MEASURES: Each subject underwent a transthoracic echocardiogram to evaluate epicardial adipose tissue thickness, a euglycemic hyperinsulinemic clamp to estimate insulin sensitivity, and an oral glucose tolerance test to evaluate glucose tolerance. RESULTS: The thickness of the epicardial adipose tissue on the right ventricle varied between 4 and 17.4 mm. Echocardiographic epicardial adipose tissue was significantly correlated with whole-body glucose uptake index from the clamp and with all indices of insulin resistance and glucose intolerance measured, except the 120-min plasma glucose level after an oral glucose tolerance test. CONCLUSIONS: Our study showed that the epicardial fat is significantly related to obesity-related insulin resistance. This finding could be of potential interest in clinical practice and research of obesity-related risk stratification.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In non-diabetic people, impaired fasting glucose, or obesity-related reduction of insulin sensitivity, as assessed by euglycemic hyperinsulinemic clamp and other markers of insulin resistance, are associated with increased epicardial fat [19,55].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [55]
In the citing paper
“Epicardial adipose tissue can be easily measured with standard ultrasound and independently reflects intra-abdominal visceral fat and myocardial triglyceride content [7–10].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [9]
In the citing paper
“EAT has shown to be a modifiable and measurable cardiovascular risk factor that is thicker in subjects with diabetes, owing to its strong correlation with visceral adiposity and insulin resistance [7–9].”
From Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity (2020) · cites this paper as [9]
In the citing paper
“Iacobellis and colleagues (152, 155) have argued that the amount of epicardial fat parallels the amount of visceral adipose tissue and that the amount of epicardial fat is correlated with the severity of LVH.”
From Cardiac remodeling in obesity (2008) · cites this paper as [152]
In the citing paper
“One study used MRI spectroscopy to quantify triglyceride content in human myocardium and found it to be significantly increased in obese compared with normal-weight subjects (152).”
From Cardiac remodeling in obesity (2008) · cites this paper as [152]
Citations
Cites
Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus* (2002) · Diabetes Care · doi:10.2337/diacare.25.2007.s5 · Cited by 10,325
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Human epicardial adipose tissue is a source of inflammatory mediators
Mazurek, T., Zhang, L., Zalewski, A., Mannion, J. D., Diehl, J. T., Arafat, H., Sarov-Blat, L., O’Brien, S., Keiper, E. A., Johnson, A. G., et al. (2003) · Circulation · doi:10.1161/01.cir.0000099542.57313.c5 · Cited by 1,966
The glycemic index: methodology and clinical implications
Wolever, T., Jenkins, D., Jenkins, A., & Josse, R. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.5.846 · Cited by 1,168
Iacobellis, G., Ribaudo, M. C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., Di Mario, U., & Leonetti, F. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030698 · Cited by 842
Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction
Iacobellis, G., Assael, F., Ribaudo, M. C., Zappaterreno, A., Alessi, G., Di Mario, U., & Leonetti, F. (2003) · Obesity Research · doi:10.1038/oby.2003.45 · Cited by 779
Relationships of generalized and regional adiposity to insulin sensitivity in men.
Abate, N., Garg, A., Peshock, R. M., Stray-Gundersen, J., & Grundy, S. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118083 · Cited by 759
Iacobellis, G., Pistilli, D., Gucciardo, M., Leonetti, F., Miraldi, F., Brancaccio, G., GALLO, P., & Gioia, C. R. T. D. (2005) · Cytokine · doi:10.1016/j.cyto.2004.11.002 · Cited by 445
Relationship between Generalized and Upper Body Obesity to Insulin Resistance in Asian Indian Men
Chandalia, M., Abate, N., Garg, A., Stray‐Gundersen, J., & Grundy, S. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.7.5817 · Cited by 402
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–355 of 355
The impact of epicardial adiposity on STEMI outcomes: Insights from a prospective cohort
Murat, A., Karaca, G., Bakhshaliyev, N., Ekmekçi, A., Kimiaei, A., Safaei, S., & Eren, M. (2025) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.70034 · Cited by 1
Fazio, S., & Carlomagno, G. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1719492 · Cited by 3
Mazzoccoli, G., Dagostino, M. P., Grilli, M., Copetti, M., Fontana, A., Pellegrini, F., & Greco, A. (2011) · Biomedicine & Aging Pathology · doi:10.1016/j.biomag.2011.06.001 · Cited by 1
Netyazhenko, V. Z., & Bidzilya, P. P. (2014) · Zaporozhye Medical Journal · doi:10.14739/2310-1210.2014.2.25234 · Cited by 1
Morphological Nasal Changes Associated with Rapid Maxillary Expansion
Polat, K., Uysal, İ. Ö., Zorkun, B., Yüce, S., Birlik, M., & Babacan, H. (2015) · Electronic Journal of General Medicine · doi:10.15197/sabad.1.12.28 · Cited by 1
Wierzbowska-Drabik, K. A., & Kasprzak, J. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-67691-3_45 · Cited by 1
Кравчун, П. П. (2014) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.6.62.2014.76934 · Cited by 1
Adrenal Secretome and Epicardial Adipose Tissue
Petramala, L., Concistrè, A., Iannucci, G., & Letizia, C. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-40570-0_14 · Cited by 1
Sridhar, C., & Bhaskar, J. (2021) · doi:10.52403/ijrr.20210274 · Cited by 1
Lima-Martínez, M. M., Colmenares, L., Campanelli, Y., Paoli, M., Rodney, M., Santos, R. D., & Iacobellis, G. (2019) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2018.06.004 · Cited by 1
Exosomes as Crucial Player in Insulin Resistance and Obesity: Potential Therapeutic Approach
Sood, S., Devi, S., Singh, T. G., Yadav, N., Kumar, P., & Chatterjee, A. (2022) · International Journal of Pharmaceutical Quality Assurance · doi:10.25258/ijpqa.13.4.26 · Cited by 4
The relationship of epicardial adipose tissue and metabolic syndrome
Аликовна, М. И., Dolganov, A. A., Kutlubaev, M. A., & Zagidullin, N. S. (2023) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2023-29-2-186-193 · Cited by 1
Raafat, S., Ahmed, R. A., Mowafi, I., & Adel, H. M. (2023) · Hormone Research in Paediatrics · doi:10.1159/000535630 · Cited by 1
Effects of insulin resistance on cardiovascular risk factors in obese and non-obese patients
Tarım, B. A., Papila-Topal, N., Keskin, Ö., Faikoğlu, G., Saygisever-Faikoglu, K., & Uskur, T. (2023) · The European Research Journal · doi:10.18621/eurj.1363228 · Cited by 1
Echocardiographic Epicardial Adipose Tissue Thickness as a Marker of Insulin Resistance
Tan-Ramos, K. C., Sy, R. A., & Choa, V. (2014) · Journal of the ASEAN Federation of Endocrine Societies · doi:10.15605/jafes.029.02.05 · Cited by 1
Yeon, S. B., & Oyama, N. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06686-3.00036-9 · Cited by 1
Prefácio do livro: Marcadores de obesidade na avaliação do estado nutricional em adolescente
Rosa, G. (2021) · Bookerfield Editora · doi:10.53268/bkf21110398 · Cited by 1
Phenotypic classification and biochemical profile of obesity for cardiovascular prevention
Perrone, M. A., Dasari, J. B., Intorcia, A., Gualtieri, P., Marche, M., Luozzo, M. D., Merra, G., Bernardini, S., Romeo, F., & Sergi, D. (2020) · Gazzetta Medica Italiana Archivio per le Scienze Mediche · doi:10.23736/s0393-3660.20.04259-x · Cited by 1
Shahawy, M. E., Izadi, L., Sabatini, A., TUCKER, S. M., Patella, J., Shahawy, O. E., & Yturralde, F. (2020) · medRxiv · doi:10.1101/2020.06.28.20141622 · Cited by 1
Lima‐Leopoldo, A. P. (2010) · doi:10.5016/dt000614088 · Cited by 1
Patel, N. N. (2014) · UPT. Syiah Kuala University Library (Syiah Kuala University)
Paulino, E. C. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2009.tde-08032010-154558
Insulin resistance and adipose tissue in the development of vascular diseases in high-risk patients
Gorter, P. M. (2008) · Utrecht University Repository (Utrecht University)
Tejido adiposo epicárdico: su relación con enfermedades cardiovasculares
Rivera, T. G. Y., Blé‐Castillo, J. L., García, M. A. B., Hernández, M. E. T., & Vázquez, C. G. (2014) · Horizonte Sanitario · doi:10.19136/hs.a12n3.78
Oxana, D., Zyatenkova, E. V., & Vladimir, I. (2015) · American journal of clinical medicine research · doi:10.12691/ajcmr-3-3-4
Lipomatoz mezhpredserdnoy peregorodkii epikardial'nyy zhir: klinicheskoe znachenie
Solov'eva, A. V., Вулех, В. М., Степановна, Я. М., Труфанов, К. В., & Rakita, D. R. (2011) · Obesity and metabolism · doi:10.14341/2071-8713-4950
Epicardial Adipose Tissue: New Kid on the Block
Mahabadi, A. A., & Dykun, I. (2014) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-014-0383-8
Prakaschandra, R. (2013) · ResearchSpace (University of KwaZulu-Natal)
Baldasseroni, S., Pratesi, A., Orso, F., Foschini, A., Marella, A. G., Bartoli, N., Fumagalli, S., Marchionni, N., & Tarantini, F. (2013)
Obesity and Cardiac Dysfunction
Sweeney, G., Litwin, S. E., & Abel, E. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_14
FUNCTIONAL MYOCARDIAL CONDITION IN CHRONIC HEART FAILURE WITH CONCOMITANT OBESITY
Netyazhenko, V. Z., & Bidzilya, P. P. (2014) · Pathologia · doi:10.14739/2310-1237.2014.1.25200
Netyazhenko, V. Z., & Bidzilya, P. P. (2014) · The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy
Adipose tissue metabolism and cardiometabolic health in obesity
Stinkens (2017) · Research Publications (Maastricht University) · doi:10.26481/dis.20171005rs
Le tissu adipeux épicardique : un nouveau facteur de risque cardio-métabolique ?
Germain, P., & Schlienger, J.-L. (2011) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(11)70210-3
Glukoz metabolizma bozukluklarında subklinik aterosklerozun değerlendirilmesi
Aydın, E., Altın, C., Emre, S., Ağıldere, A. M., & Tekindal, M. A. (2018) · Ege Tıp Dergisi · doi:10.19161/etd.416642
Cardiometabolic Risk and Epicardial Adipose Tissue
Iacobellis, G., & Fricke, A. C. V. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-40570-0_13
Shahawy, M. E., Mohan, S., & Sabatini, A. (2021) · Journal of Integrative Cardiology · doi:10.15761/jic.1000306
Association of Epicardial Adipose Tissue with Essential Hypertension: A Meta-AnalysisPreprint
Zou, X., Li, Y., She, Q., & Liu, B. (2021) · Research Square · doi:10.21203/rs.3.rs-684093/v1
INVESTIGATION OF THE RELATIONSHIP BETWEEN EPICARDIAL FAT TISSUE THICKNESS AND HEMOGLOBIN A1c LEVELS
Aydın, F., & Yıldırım, Ö. T. (2021) · Cukurova Anestezi ve Cerrahi Bilimler Dergisi · doi:10.36516/jocass.2021.75
Cardiovascular comorbidity in patients with nonalcoholic fatty liver disease
Ledovskaya, T. I., Statsenko, M., Туркина, С. В., Konyakhina, T., Yusupov, K., & Gorbacheva, E. E. (2021) · Medicine of Extreme Situations · doi:10.47183/mes.2021.045
Erdal, E., İnanır, M., Ustaoğlu, G., & Sıncer, İ. (2020) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2020.06.006
Leb, J. S., & Hong, S. N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-41561-3.00047-1
(2024) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2024.344775
Coşgun, Z., & Kalfaoğlu, M. E. (2024) · Northwestern Medical Journal · doi:10.54307/2024.nwmj.95
Wierzbowska-Drabik, K. A., & Kasprzak, J. D. (2026) · Springer eBooks · doi:10.1007/978-3-032-02269-1_61
Yin, S., Zhao, X., Liu, Q., Fu, T., Sun, Q., Pan, Y., Wang, M., Wang, B., Gong, M., Lu, Y., et al. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1778193
Zengin, E., Uçgun, A., Çevik, M. E., Evrimler, Ş., & Doğan, İ. S. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343831
Tissu adipeux ectopique et pathologie cardiaque
Gaborit, B. (2013) · theses.fr (ABES) · doi:10.70675/950549dfzb0e2z4faaz9e53z9e9fd1812f11
Dépôts de graisse ectopique : étude de leur développement et de leur modulation
Abdesselam, I. (2016) · theses.fr (ABES) · doi:10.70675/1f016024z175cz4b35z8034za3b418cfe9c3
Hassan, M. A., Mamdouh, M., Ahmed, F.-A., & Allam, K. M. (2026) · European Journal of Pediatrics · doi:10.1007/s00431-026-06997-1
Trimukhe, D. M., Phatak, S., Onkar, P. M., & Kajal, M. (2026) · Journal of the Indian Medical Association · doi:10.5005/jima-11070-0021
Wei, L., Zhao, C.-X., Dong, J.-X., Qiu, X.-H., Lee, A. P., Ge, H., & Pu, J. (2026) · BMC Medical Imaging · doi:10.1186/s12880-026-02527-5
Epicardial Adipose Tissue in Hyperglucagonemia mice: an experimental model for GLP-1 triple agonistsPreprint
Iacobellis, G., Mazuecos, L., Neves, A. F., & Bernal‐Mizrachi, E. (2026) · Research Square · doi:10.21203/rs.3.rs-10616455/v1
Metadata
- Authors
- Iacobellis, G., & Leonetti, F.
- Affiliations
- Policlinico Umberto I (IT)
- Sapienza University of Rome (IT)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-11
- Volume
- 90
- Issue
- 11
- Pages
- 6300-6302
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2033442974
- Cited by
- 355
- References
- 18
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 9 · 2023: 18 · 2022: 12 · 2021: 15 · 2020: 21 · 2019: 11 · 2018: 20 · 2017: 14 · 2016: 18 · 2015: 24 · 2014: 30 · 2013: 30 · 2012: 19
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- epicardial adipose tissue, insulin resistance, obesity, visceral fat, glucose metabolism, glucose tolerance, echocardiographic measurement, hyperinsulinemic-euglycemic clamp, whole-body glucose uptake
- MeSH terms
- Adipose Tissue, Adult, Echocardiography, Female, Glucose, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Pericardium
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
