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Cited by 759

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Levothyroxine Treatment in Euthyroid Pregnant Women with Autoimmune Thyroid Disease: Effects on Obstetrical Complications

Open access
Negro, Roberto, Formoso, Gianni, Mangieri, Tiziana, Pezzarossa, Antonio, Dazzi, Davide, Hassan, Haslinda·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-1603
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Abstract

CONTEXT: Euthyroid women with autoimmune thyroid disease show impairment of thyroid function during gestation and seem to suffer from a higher rate of obstetrical complications. OBJECTIVE: We sought to determine whether these women suffer from a higher rate of obstetrical complications and whether levothyroxine (LT(4)) treatment exerts beneficial effects. DESIGN: This was a prospective study. SETTING: The study was conducted in the Department of Obstetrics and Gynecology. PATIENTS: A total of 984 pregnant women were studied from November 2002 to October 2004; 11.7% were thyroid peroxidase antibody positive (TPOAb(+)). INTERVENTION: TPOAb(+) patients were divided into two groups: group A (n = 57) was treated with LT(4), and group B (n = 58) was not treated. The 869 TPOAb(-) patients (group C) served as a normal population control group. MAIN OUTCOME MEASURES: Rates of obstetrical complications in treated and untreated groups were measured. RESULTS: At baseline, TPOAb(+) had higher TSH compared with TPOAb(-); TSH remained higher in group B compared with groups A and C throughout gestation. Free T(4) values were lower in group B than groups A and C after 30 wk and after parturition. Groups A and C showed a similar miscarriage rate (3.5 and 2.4%, respectively), which was lower than group B (13.8%) [P < 0.05; relative risk (RR), 1.72; 95% confidence interval (CI), 1.13-2.25; and P < 0.01; RR = 4.95; 95% CI = 2.59-9.48, respectively]. Group B displayed a 22.4% rate of premature deliveries, which was higher than group A (7%) (P < 0.05; RR = 1.66; 95% CI = 1.18-2.34) and group C (8.2%) (P < 0.01; RR = 12.18; 95% CI = 7.93-18.7). CONCLUSIONS: Euthyroid pregnant women who are positive for TPOAb develop impaired thyroid function, which is associated with an increased risk of miscarriage and premature deliveries. Substitutive treatment with LT(4) is able to lower the chance of miscarriage and premature delivery.

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Metadata

Authors
Negro, R., Formoso, G., Mangieri, T., Pezzarossa, A., Dazzi, D., & Hassan, H.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-07-01
Volume
91
Issue
7
Pages
2587-2591
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-1603
OpenAlex
W2157641854
Cited by
759
References
5
FWCI
21.58
Type
journal article
Language
en
Open access
bronze

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