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Cited by 102Regulation of Appetite and ObesityDiabetes, Cardiovascular Risks, and LipoproteinsAdipokines, Inflammation, and Metabolic Diseases

The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers

Muldoon, Matthew F., Mackey, Rachel H., Korytkowski, Mary T., Flory, Janine D., Pollock, Bruce G., Manuck, Stephen B.·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-1654
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Abstract

CONTEXT: The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism. OBJECTIVE: The objective of this study was to test the hypothesis that low central serotonergic activity is associated with the metabolic syndrome. DESIGN, SETTING, PARTICIPANTS: This was a cross-sectional study of 345 healthy community volunteers, aged 30-55 yr, not taking medications for hypertension, lipid disorders, or diabetes. OUTCOME MEASURES: Central serotonergic responsivity was assessed with the iv citalopram challenge test. The serum prolactin area under the curve (AUC) over 150 min was calculated, and all analyses were adjusted for age, sex, plasma citalopram concentration, and baseline prolactin. The metabolic syndrome was defined according to the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF) criteria. Insulin resistance was estimated by homeostasis model assessment. RESULTS: Compared with other individuals, persons meeting either NCEP or IDF criteria for the metabolic syndrome had lower mean prolactin responses (P < 0.05 for both). Using logistic regression, a decrease in prolactin AUC of 1 sd (-13.6 ng/ml.h) more than doubled the odds of having the metabolic syndrome (NCEP criteria: odds ratio, 2.38; 95% confidence interval, 1.14-4.97; P = 0.02; IDF criteria: odds ratio, 2.80; 95% confidence interval, 1.48-5.30; P = 0.002). Finally, the prolactin AUC was negatively associated with insulin resistance (beta = -0.03, P = 0.02). CONCLUSIONS: Corroborating previous evidence, the metabolic syndrome was associated with diminished brain serotonergic activity as reflected in a comparative blunting of the prolactin response to a selective serotonergic challenge. This association may have implications for the etiology, prevention, and treatment of the metabolic syndrome.

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  • Diminished central serotonergic function is a biologically plausible shared antecedent for metabolic dysregulation and neuropsychiatric vulnerability; reduced serotonin availability has been linked to increased appetite, weight gain, central adiposity, impaired glucose tolerance, insulin resistance, and depressed mood.

    “A biologically plausible shared antecedent is diminished central serotonergic function. Reduced serotonin availability has been linked to increased appetite and weight gain, central adiposity, impaired glucose tolerance, and insulin resistance, alongside depressed mood (88).”

    From Exploring the neurobiological markers of suicidal behaviors in pediatric population: a narrative review (2026) · cites this paper as [88]

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  1. Sanders-Bush E, Mayer S 2001 5-Hydroxytryptamine (serotonin) receptor agonists and antagonists. In: Hardman JG, Limbird LE, eds. Goodman, Gil- man's the pharmacological basis of therapeutics. New York: McGraw-Hill; 269 -290

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Authors
Muldoon, M. F., Mackey, R. H., Korytkowski, M. T., Flory, J. D., Pollock, B. G., & Manuck, S. B.
Affiliations
  • University of Pittsburgh (US)
  • Departments of Medicine and Epidemiology (R.H.M.), Pittsburgh, Pennsylvania 15260
  • Endocrinology (M.T.K.), Pittsburgh, Pennsylvania 15260
  • Icahn School of Medicine at Mount Sinai (US)
  • University of Toronto (CA)
Corresponding author
Muldoon, Matthew F.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-02-01
Volume
91
Issue
2
Pages
718-721
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-1654
OpenAlex
W2003538836
Cited by
102
References
19
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 6 · 2014: 2 · 2013: 10 · 2012: 12
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Pittsburgh
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (P01HL040962)
  • National Institute of Mental Health (K24MH065416)
  • National Center for Research Resources (M01RR000056)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
metabolic syndrome, prolactin, insulin resistance, hypothalamic-pituitary regulation, healthy adults
MeSH terms
Adult, Brain, Cross-Sectional Studies, Female, Humans, Insulin Resistance, Male, Middle Aged, Prolactin, Serotonin, Citalopram, Logistic Models, Selective Serotonin Reuptake Inhibitors, Area Under Curve, Metabolic Syndrome

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