The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Contributions of Different Fatty Acid Sources to Very Low-Density Lipoprotein-Triacylglycerol in the Fasted and Fed States
Open accessAbstract
CONTEXT: The liver's regulation of fatty acids (FAs) postprandially may contribute to risk of metabolic diseases. OBJECTIVE: Measurements of steady-state metabolism were used to investigate sources of FAs used for very low-density lipoprotein (VLDL)-triacylglycerol (TG) synthesis during fasting and feeding in vivo. DESIGN/INTERVENTION: Subjects were duodenally fed a formula labeled with the stable isotope glyceryl tri-palmitate-d(31) and iv infused with [1,2,3,4-(13)C(4)]-palmitatic acid and [1-(13)C(1)]-acetate to quantitate the liver's use of FAs originating from adipose tissue and de novo lipogenesis. SETTING/PARTICIPANTS: This study of healthy men (n = 12; body mass index, 24.4 +/- 2.7 kg/m(2)) was conducted at a General Clinical Research Center. MAIN OUTCOME MEASURES: Concentrations of metabolites during fasting and feeding, sources of FAs used for lipoprotein synthesis, rate of appearance of serum nonesterified FA (NEFA), and VLDL-TG were measured. RESULTS: During fasting, 77.2 +/- 14.0% of VLDL-TG was derived from adipose FA recycling and 4.0 +/- 3.6% from lipogenesis; with feeding, 43.6 +/- 18.6% came from adipose FAs (P < 0.001), 8.2 +/- 5.1% from lipogenesis (P < 0.001), 15.2 +/- 13.7% from uptake of chylomicron-remnant TG, and 10.3 +/- 6.9% from dietary FA spillover into the serum NEFA pool. Fed-state VLDL-TG from NEFA reesterification decreased in proportion to the reduction in adipose NEFA appearance. CONCLUSION: These data: 1) quantify the extent to which the healthy liver manages its use of different sources of FAs that flow to it, 2) demonstrate how the postprandial reduction in adipose-NEFA flux may be partially replaced by other sources, and 3) highlight the potential for dietary FA spillover to support the continued dominance of NEFA as a substrate for VLDL-TG synthesis.
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“In well-fasted, lean subjects, FFAs derived from adipose tissue stores are the primary source of FAs used by the liver for VLDL-TG synthesis, while DNL typically represents about 5%–10% of these sources, and dietary contribution in the fasting state is usually minor [68].”
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Self-citation
Metadata
- Authors
- Barrows, B. R., & Parks, E. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-04
- Volume
- 91
- Issue
- 4
- Pages
- 1446-1452
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2154119553
- Cited by
- 272
- References
- 5
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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