CoChat
Sign Up
Cited by 82Sexual Differentiation and DisordersBone health and osteoporosis researchAdrenal Hormones and Disorders

Reduced Bone Mineral Density and Increased Bone Metabolism Rate in Young Adult Patients with 21-Hydroxylase Deficiency

Sciannamblo, Mariateresa, Russo, Gianni, Cuccato, Debora, Chiumello, Giuseppe, Mora, Stefano·2006·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2005-2823
Open this paper in CoChat — free account

Abstract

Context: Patients with congenital adrenal hyperplasia (CAH) receive glucocorticoids as replacement therapy. Glucocorticoid therapy is the most frequent cause of drug-induced osteoporosis. Objective: The objective of the study was to evaluate bone mineral density (BMD) and bone metabolism in CAH patients. Design: This was a cross-sectional observational study. Setting: The study was conducted at a referral center for pediatric endocrinology. Patients and Other Participants: Thirty young patients with the classical form of CAH (aged 16.4–29.7 yr) treated with glucocorticoid from diagnosis (duration of treatment 16.4–29.5 yr) and 138 healthy controls (aged 16.0–30.0 yr) were enrolled. Main Outcome Measures: BMD was measured in the lumbar spine and whole body by dual-energy x-ray absorptiometry. Bone formation and resorption rates were estimated by serum measurements of bone-specific alkaline phosphatase and C-terminal telopeptide of type I collagen, respectively. Results: CAH patients were shorter than controls (women −6.8 and men −13.3 cm). Therefore, several methods were used to account for the effect of this difference on bone measurements. Whole-body BMD measurements were significantly lower, compared with controls (P < 0.03), after controlling for height (on average −2.5% in females and −9.3% in male patients). No differences were found in lumbar spine measurements. Bone-specific alkaline phosphatase and C-terminal telopeptide of type I collagen serum concentrations were higher in CAH patients than control subjects (P < 0.04). BMD measurements and bone metabolism markers did not correlate with the actual glucocorticoid dose or mean dose over the previous 7 yr. Conclusions: Young adult patients with the classical form of CAH have decreased bone density values, compared with healthy controls. This may put them at risk of developing osteoporosis early in life.

Integrity signals

Registry

Crossref · 10.1210/jc.2005-2823

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 40 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Sciannamblo, M., Russo, G., Cuccato, D., Chiumello, G., & Mora, S.
Affiliations
Vita-Salute San Raffaele University (IT)
Corresponding author
Mora, Stefano
ORCID
Mora, Stefano
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-11-01
Volume
91
Issue
11
Pages
4453-4458
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2005-2823
OpenAlex
W2124293721
Cited by
82
References
40
Citations by year
2025: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 7 · 2013: 5 · 2012: 6
FWCI
1.49
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
congenital adrenal hyperplasia, 21-hydroxylase deficiency, bone mineral density, bone metabolism, glucocorticoid therapy, drug-induced osteoporosis, bone-specific alkaline phosphatase, C-terminal telopeptide of type I collagen, young adults, height, osteoporosis risk
MeSH terms
Adolescent, Adrenal Hyperplasia, Congenital, Adult, Bone and Bones, Cross-Sectional Studies, Female, Glucocorticoids, Humans, Male, Osteoporosis, Biomarkers, Absorptiometry, Photon, Bone Density, Case-Control Studies, Hormone Replacement Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review