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Serum Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovarian Syndrome
Abstract
Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes. Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers. Design and Setting: A prospective baseline-controlled clinical study was conducted at the University “Federico II” of Naples School of Medicine (Naples, Italy). Patients: Fifty PCOS women age- and body mass index-matched with 50 healthy women were enrolled. Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control. Results: Aldosterone levels were significantly increased (P < 0.001) in PCOS compared with healthy women (10.5 ± 3.2 vs. 5.7 ± 2.5 ng/dl). In PCOS, a significant (P < 0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P < 0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS. Conclusion: PCOS women show an insulin resistance related increase in serum aldosterone levels.
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“It is known that aldosterone is the main proinflammatory hormone and, unfortunately, the use of COCs stimulates the synthesis of angiotensinogen and activates the renin–angiotensin–aldosterone system (RAAS) [13,14,68].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [68]
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“It is known that aldosterone is the main proinflammatory hormone and, unfortunately, the use of COCs stimulates the synthesis of angiotensinogen and activates the renin–angiotensin–aldosterone system (RAAS) [13,14,68].”
From Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism (2022) · cites this paper as [68]
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Epidemiology, diagnosis, and management of polycystic ovary syndrome
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Metadata
- Authors
- Cascella, T., Palomba, S., Tauchmanovà, L., Manguso, F., Di Biase, S., Labella, D., Giallauria, F., Vigorito, C., Colao, A., Lombardi, G., & Orio, F.
- Affiliations
- University of Naples Federico II (IT)
- Magna Graecia University (IT)
- Department of Molecular and Clinical Endocrinology and Oncology (T.C., L.T., A.C., G.L., F.O.),” 80131 Naples, Italy
- MeriGen Laboratory of Molecular Biology (S.D.B., D.L.), 80131 Naples, Italy
- Federico II University Hospital (IT)
- Corresponding author
- Orio, Francesco
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2006-11-01
- Volume
- 91
- Issue
- 11
- Pages
- 4395-4400
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2090608637
- Cited by
- 120
- References
- 48
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 9 · 2018: 6 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 7
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- CINECA IRIS Institutial research information system (Parthenope University of Naples) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, serum aldosterone, cardiovascular risk, insulin resistance, intima-media thickness, C-reactive protein, renin, atherosclerosis, HOMA, blood pressure, HDL cholesterol, potassium, women
- MeSH terms
- Adult, Aldosterone, Cardiovascular Diseases, Female, Humans, Polycystic Ovary Syndrome, Prospective Studies, Risk Factors, Causality, Case-Control Studies, Atherosclerosis
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