Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment

DeUgarte, Catherine Marin; Bartolucci, Alfred A.; Azziz, Ricardo

doi:10.1016/j.fertnstert.2004.11.070

Cited by 589Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment

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DeUgarte, Catherine Marin, Bartolucci, Alfred A., Azziz, Ricardo·2005·Fertility and Sterility

DOI 10.1016/j.fertnstert.2004.11.070

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Abstract

Objective To determine the prevalence of insulin resistance (IR) in a large population of patients with the polycystic ovary syndrome (PCOS).Design Prospective, case-control.Setting University medical center.Patient(s) Two hundred seventy-one PCOS patients and 260 eumenorrheic, non-hirsute, control women.Intervention(s) History and physical examination and blood sampling.Main outcome measure(s) Total T, free T, DHEAS, sex hormone-binding globulin, and fasting glucose and insulin levels; homeostatic model assessment values for IR (HOMA-IR) and percent beta-cell function (HOMA-%beta-cell).Result(s) Patients with PCOS and controls differed significantly in all parameters studied, except fasting glucose. Because the HOMA-IR and HOMA-%beta-cell values were variably associated with race, age, and body mass index, the HOMA-IR and HOMA-%beta-cell values were then adjusted for these cofounders. After adjustment, 64.4% of PCOS patients were noted to be insulin resistant, and 2.6% had beta-cell dysfunction. Compared with PCOS patients without IR (n = 96), patients with IR (n = 174) were more obese and had higher beta-cell function.Conclusion(s) In patients with PCOS, the prevalence of IR was 64% according to the HOMA-IR measurement, after adjustment. Patients with IR were more clinically affected. Although IR is a common abnormality in PCOS, it does not seem to be a universal feature.

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IR is present in around 50%-80% of women with PCOS, independent of obesity.
“IR is present in around 50%80% of women with PCOS, independent of obesity, 101”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [101]

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Prevalence of insulin resistance in Korean women with polycystic ovary syndrome according to various homeostasis model assessment for insulin resistance cutoff values
Kim, J., Hwang, K. R., Oh, S. H., Chae, S. J., Yoon, S. H., & Choi, Y. M. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.06.035 · Cited by 34 · see citing works
Insulin Resistance and β-cell Function Calculated by Homeostasis Model Assessment in Lean, Overweight, and Obese Women with Polycystic Ovary Syndrome.
Sirota, I., De, S., Vega, M., & Keltz, M. D. (2016) · PubMed · Cited by 4 · see citing works

Authors: DeUgarte, C. M., Bartolucci, A. A., & Azziz, R.
Affiliations: Cedars-Sinai Medical Center (US)
University of Alabama at Birmingham (US)
Corresponding author: Azziz, Ricardo
ORCID: Bartolucci, Alfred A.
Azziz, Ricardo
Venue: Fertility and Sterility
Publisher: Elsevier BV
Published: 2005-05
Volume: 83
Issue: 5
Pages: 1454-1460
ISSN: 0015-0282 (ISSN-L)
DOI: 10.1016/j.fertnstert.2004.11.070
OpenAlex: W2117559317
Cited by: 589
References: 62
Citations by year: 2026: 14 · 2025: 23 · 2024: 24 · 2023: 30 · 2022: 41 · 2021: 32 · 2020: 33 · 2019: 33 · 2018: 23 · 2017: 28 · 2016: 32 · 2015: 37 · 2014: 33 · 2013: 48 · 2012: 21
FWCI: 23.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 6235 d)
Locations: Fertility and Sterility (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords: polycystic ovary syndrome, insulin resistance, HOMA-IR, beta-cell function, prevalence, obesity, sex hormones, insulin secretion
MeSH terms: Adult, Female, Homeostasis, Humans, Insulin Resistance, Middle Aged, Polycystic Ovary Syndrome, Prospective Studies, Prevalence, Chi-Square Distribution, Case-Control Studies

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Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment

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