Prevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Ehrmann, David A.; Liljenquist, David R.; Kasza, Kristen; Azziz, Ricardo; Legro, Richard S.; Ghazzi, Mahmoud N.

doi:10.1210/jc.2005-1329

Cited by 703Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsDiet, Metabolism, and Disease

Prevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Ehrmann, David A., Liljenquist, David R., Kasza, Kristen, Azziz, Ricardo, Legro, Richard S., Ghazzi, Mahmoud N.·2006·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2005-1329

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Abstract

CONTEXT: Polycystic ovary syndrome (PCOS) and the metabolic syndrome have many features in common and may share the same pathogenesis. OBJECTIVE: This study was performed to determine the prevalence and predictors of the metabolic syndrome in PCOS. DESIGN: The clinical, hormonal, and oral glucose tolerance test results were analyzed in 394 PCOS women who were screened for participation in a multicenter trial to evaluate the effects of troglitazone on ovulation and hirsutism. SETTING: A multicenter clinical trial is presented. PATIENTS OR OTHER PARTICIPANTS: The subjects were women with PCOS who had or lacked the metabolic syndrome. MAIN OUTCOME MEASURES: Waist circumference, fasting glucose, high-density lipoprotein cholesterol and triglyceride concentrations, and blood pressure were the main outcome measures. RESULTS: Twenty-six (6.6%) subjects had diabetes; among the 368 nondiabetics, the prevalence for individual components comprising the metabolic syndrome were: waist circumference greater than 88 cm in 80%, high-density lipoprotein cholesterol less than 50 mg/dl in 66%, triglycerides greater than or equal to 150 mg/dl in 32%, blood pressure greater than or equal to 130/85 mm Hg in 21%, and fasting glucose concentrations greater than or equal to 110 mg/dl in 5%. Three or more of these individual criteria were present in 123 (33.4%) subjects overall. The prevalence of the metabolic syndrome did not differ significantly between racial/ethnic groups. The prevalence of the metabolic syndrome from lowest to highest quartile of free testosterone concentration was 19.8, 31.3, 46.9, and 35.0%, respectively [P = 0.056 adjusted for body mass index (BMI)]. None of the 52 women with a BMI less than 27.0 kg/m2 had the metabolic syndrome; those in the top BMI quartile were 13.7 times more likely (95% confidence interval, 5.7-33.0) to have the metabolic syndrome compared with those in the lowest quartile. Thirty-eight percent of those with the metabolic syndrome had impaired glucose tolerance compared with 19% without the metabolic syndrome (P < 0.001). CONCLUSIONS: The metabolic syndrome and its individual components are common in PCOS, particularly among women with the highest insulin levels and BMI. Hyperinsulinemia is a likely common pathogenetic factor for both PCOS and the metabolic syndrome.

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Increased susceptibility to obesity may further exacerbate insulin resistance and metabolic dysfunctions in PCOS.
“whilst their increased susceptibility to obesity [16] may further exacerbate IR and the accompanying metabolic [17, 18] and reproductive [10, 19] dysfunctions.”
From Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis (2019) · cites this paper as [18]
In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD have been noted and are related to IR and obesity.
“In PCOS, other novel CVD risk factors, premature cardiovascular dysfunction and subclinical CVD 29,30,83 have been noted and are related to IR and obesity. 84-89”
From Assessment and management of polycystic ovary syndrome: Summary of an evidence-based guideline (2011) · cites this paper as [84]

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Authors: Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., & Ghazzi, M. N.
Affiliations: University of Chicago (US)
University of Alabama (US)
Pennsylvania State University (US)
Pfizer (United States) (US)
Corresponding author: Ehrmann, David A.
ORCID: Azziz, Ricardo
Legro, Richard S.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2006-01
Volume: 91
Issue: 1
Pages: 48-53
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2005-1329
OpenAlex: W2121081996
Cited by: 703
References: 26
Citations by year: 2026: 4 · 2025: 17 · 2024: 22 · 2023: 31 · 2022: 26 · 2021: 27 · 2020: 27 · 2019: 37 · 2018: 37 · 2017: 30 · 2016: 35 · 2015: 46 · 2014: 38 · 2013: 39 · 2012: 52
FWCI: 55.95
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (M01-RR 00055, M01RR000055)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: polycystic ovary syndrome, metabolic syndrome, prevalence, risk factors, body mass index, insulin resistance, free testosterone, impaired glucose tolerance, diabetes mellitus, waist circumference, dyslipidemia, blood pressure, troglitazone, racial and ethnic differences, women's health, hyperandrogenism, insulin sensitizers, oral glucose tolerance test, insulin sensitivity
MeSH terms: Adult, Blood Glucose, Blood Pressure, Diabetes Mellitus, Female, Glucose Tolerance Test, Humans, Insulin, Cholesterol, HDL, Obesity, Polycystic Ovary Syndrome, Predictive Value of Tests, Testosterone, Cohort Studies, Biomarkers, Metabolic Syndrome, Waist-Hip Ratio

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Prevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

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