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Cited by 139Sexual Differentiation and DisordersAdrenal Hormones and DisordersTesticular diseases and treatments

The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.

Testicular Adrenal Rest Tumors in Adult Males with Congenital Adrenal Hyperplasia: Evaluation of Pituitary-Gonadal Function before and after Successful Testis-Sparing Surgery in Eight Patients

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Claahsen-van der Grinten, Hedi L., Otten, Barto J., Takahashi, Satoru, Meuleman, Eric J. H., Hulsbergen-van de Kaa, Christina, Sweep, Fred C. G. J., Hermus, Ad R. M. M.·2007·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2006-1311
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Abstract

CONTEXT: In male patients with congenital adrenal hyperplasia (CAH), testicular adrenal rest tumors (TART) are frequently present. These tumors can interfere with testicular function. Intensifying glucocorticoid therapy does not always lead to tumor regression and improvement of testicular function. Recently, testis-sparing surgery was introduced for treatment of TART. OBJECTIVE: The aim of this study was to evaluate tumor volume, symptoms, and pituitary-gonadal function in male patients with CAH caused by 21-hydroxylase deficiency and bilateral TART before and after testis-sparing surgery. SETTING: This study was conducted at Radboud University Nijmegen Medical Centre in The Netherlands. PATIENTS: Eight adult male CAH patients with bilateral TART and infertility were included. INTERVENTIONS: Evaluation of testicular magnetic resonance imaging, symptoms, fasting serum concentrations of ACTH, LH, FSH, inhibin B, 17-OH progesterone, androstenedione, testosterone, and estrone, and semen analysis (six of eight patients) was performed before and 6 and 22 months after testis-sparing surgery. MAIN OUTCOME MEASURES: The main outcome measures were absence of residual tumor and improvement of symptoms and pituitary-gonadal function. RESULTS: Residual tumors were not found on any of the patients' magnetic resonance imaging after surgery. Two patients reported testicular pain and discomfort that disappeared after surgery. Parameters of pituitary-gonadal function did not improve after surgery: semen analysis showed azoospermia (five patients) or oligospermia (one patient) without improvement, and all patients had persistently low inhibin B concentrations. CONCLUSION: Testis-sparing surgery did not improve pituitary-gonadal function despite successful removal of the tumors. Further studies are needed to investigate whether surgery at an earlier stage in the natural history of TART can prevent permanent testicular damage.

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Crossref · 10.1210/jc.2006-1311

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Metadata

Authors
Claahsen-van der Grinten, H. L., Otten, B. J., Takahashi, S., Meuleman, E. J. H., Hulsbergen-van de Kaa, C., Sweep, F. C. G. J., & Hermus, A. R. M. M.
Affiliations
  • Department of Paediatric Endocrinology (H.L.C.-v.d.G., B.J.O.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
  • Radboud University Medical Center (NL)
  • Department of Pathology (C.H.-v.d.K.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2006-11-07
Volume
92
Issue
2
Pages
612-615
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2006-1311
OpenAlex
W2114063488
Cited by
139
References
20
Citations by year
2026: 6 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 3 · 2015: 13 · 2014: 11 · 2013: 4 · 2012: 8
FWCI
2.85
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Surgery › Testicular diseases and treatments
Keywords
testicular adrenal rest tumor, congenital adrenal hyperplasia, 21-hydroxylase deficiency, testis-sparing surgery, pituitary-gonadal function, male infertility, azoospermia, inhibin B, tumor regression, glucocorticoid therapy, FSH and LH
MeSH terms
Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Adrenocorticotropic Hormone, Adult, Androstenedione, Biopsy, Estrone, Follicle Stimulating Hormone, Humans, Inhibins, Luteinizing Hormone, Magnetic Resonance Imaging, Male, Pituitary Gland, Postoperative Complications, Preoperative Care, Urologic Surgical Procedures, Male, Testicular Neoplasms, Testis, Testosterone, Treatment Outcome, 17-alpha-Hydroxyprogesterone, Azoospermia

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