Testicular adrenal rest tumours in young adult males with congenital adrenal hyperplasia: prevalence and impact on testicular function
Abstract
Testicular adrenal rest tumours (TARTs) have been described in patients with congenital adrenal hyperplasia (CAH). The aim of the study was to determine the prevalence of TARTs in patients with CAH, the associated factors and their impact on gonadal function. It is a prospective study concerning six young adult men with CAH, four cases with 21-hydroxylase deficiency and two cases with 11-hydroxylase deficiency. All patients were under glucocorticoid therapy. The mean age was 25 years (range: 20-31). All patients underwent a physical examination with testicular palpation, scrotal ultrasonography, a blood sample for serum testosterone, FSH, LH, inhibin B, ∆4-androstenedione and 17-OH-progesterone measurements and a semen analysis. Ultrasound revealed TARTs in four patients; three were bilateral. The mean tumour size was 6.3 ml (range: 0.02-14.1). The tumours were palpable in two cases. 17-OH-progesterone was <10 ng/ml in all cases. Decreased testosterone level was found in one case. The semen analysis revealed azoospermia in one case and poor semen quality in four patients. TARTs were common and associated with impaired spermatogenesis.
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TART has also been reported in 11βOH and HSD3B2 deficiency.
“and has also been reported in 11βOH and HSD3B2 deficiency, 117-119”
From Congenital adrenal hyperplasia (2017) · cites this paper as [119]
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Congenital adrenal hyperplasia
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- Authors
- Chihaoui, M., Kanoun, F., Chaker, F., Yazidi, M., Bouchrit, K., Mizouni, H., Feki, M., Kharrat, M., & Slimane, H.
- Affiliations
- Hôpital La Rabta (TN)
- Faculté de médecine de Tunis (TN)
- Corresponding author
- Chihaoui, M.
- Venue
- Andrologia
- Publisher
- Hindawi Limited
- Published
- 2015-04-16
- Volume
- 48
- Issue
- 1
- Pages
- 45-50
- ISSN
- 0303-4569 (ISSN-L)
- OpenAlex
- W1988596920
- Cited by
- 23
- References
- 28
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Andrologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Testicular diseases and treatments
- Keywords
- congenital adrenal hyperplasia, 21-hydroxylase deficiency, 11beta-hydroxylase deficiency, azoospermia, impaired spermatogenesis, testicular function, 17-hydroxyprogesterone, testosterone, semen quality, young men, prevalence, glucocorticoid therapy
- MeSH terms
- Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Adult, Androstenedione, Follicle Stimulating Hormone, Humans, Inhibins, Luteinizing Hormone, Male, Neoplasms, Multiple Primary, Oligospermia, Prospective Studies, Sperm Count, Sperm Motility, Testicular Neoplasms, Testosterone, Cohort Studies, Prevalence, 17-alpha-Hydroxyprogesterone, Asthenozoospermia, Azoospermia, Young Adult
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