The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Visceral Obesity and Plasma Glucose-Insulin Homeostasis: Contributions of Interleukin-6 and Tumor Necrosis Factor-α in Men
Abstract
Objective: This study examined the relationships of two inflammatory cytokines, IL-6 and TNF-α, to visceral adiposity and indices of plasma glucose-insulin homeostasis. Research Design and Methods: Plasma levels of IL-6 and TNF-α were measured in 189 untreated asymptomatic men (aged 43.7 ± 7.8 yr; body mass index 29.0 ± 4.3 kg/m2; waist girth 98.6 ± 10.3 cm). Results: Significant and positive associations were found between both cytokines with adiposity and adipose tissue distribution indices (0.15 ≤ r < 0.32; P < 0.05) as well as plasma glucose-insulin homeostasis variables (0.22 ≤ r < 0.28; P <0.05). Comparison of two subgroups, each composed of 32 overweight men (≥25 kg/m2) with similar body mass index values (28.7 kg/m2 in both groups) but with markedly different levels of visceral adipose tissue (< vs. ≥ 130 cm2), revealed significant differences only for IL-6 levels (1.42 ± 1.15 vs. 0.86 ± 0.52 pg/ml; P < 0.02 for men with high vs. low visceral adipose tissue, respectively). Finally, when subjects were stratified on the basis of their respective concentrations of IL-6 and TNF-α (using the 50th percentile of their overall distribution), an ANOVA revealed an independent contribution of IL-6 to the variation of fasting insulin (P < 0.01) and each of these two cytokines to the variation of insulin levels measured after a 75-g oral glucose challenge (P <0.01 for IL-6 and P < 0.05 for TNF-α). Conclusions: Because IL-6 appeared to be clearly associated with visceral adiposity, TNF-α rather showed associations with indices of total body fatness. Thus, TNF-α may contribute to the insulin resistance of overall obesity, whereas IL-6 may be one of the mediators of the hyperinsulinemic state specifically related to excess visceral adiposity.
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Visceral fat adipokine secretion is associated with systemic inflammation in obese humans
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Interleukin-6-deficient mice develop mature-onset obesity
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Interleukin-6 stimulates lipolysis and fat oxidation in humans
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Cited by
Assessing Adiposity: A Scientific Statement From the American Heart Association
Cornier, M.-A., Després, J.-P., Davis, N., Grossniklaus, D. A., Klein, S., Lamarche, B., Lopez-Jimenez, F., Rao, G., St-Onge, M.-P., Towfighi, A., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318233bc6a · Cited by 945
Self-citationObesity and cancer: the role of dysfunctional adipose tissue
van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J. (2009) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0372 · Cited by 715
Adipose Tissue, Inflammation and Atherosclerosis
Gustafson, B. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.3939 · Cited by 469
Reciprocal relations of subcutaneous and visceral fat to bone structure and strength
Gilsanz, V., Chalfant, J., Mo, A. O., Lee, D. C., Dorey, F. J., & Mittelman, S. D. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2422 · Cited by 351
Yessoufou, A., & Moutairou, K. (2011) · Experimental Diabetes Research · doi:10.1155/2011/218598 · Cited by 266
“Furthermore, IL-6 has been shown to be one of the mediators of hyperinsulinemic state [66], 10%−35% of the body’s basal circulating IL-6 is derived from adipose tissue, and a positive correlation has been found between insulin resistance and circulating IL-6 [57].”
Background
Metadata
- Authors
- Cartier, A., Lemieux, I., Alméras, N., Tremblay, A., Bergeron, J., & Després, J.-P.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2008-05-01
- Volume
- 93
- Issue
- 5
- Pages
- 1931-1938
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2090086221
- Cited by
- 161
- References
- 11
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Cartier, A., Lemieux, I., Alméras, N., Tremblay, A., Bergeron, J., & Després, J.-P. (2008). Visceral Obesity and Plasma Glucose-Insulin Homeostasis: Contributions of Interleukin-6 and Tumor Necrosis Factor-α in Men. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2007-2191
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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