Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

van Kruijsdijk, Rob C.M.; van der Wall, Elsken; Visseren, Frank L.J.

doi:10.1158/1055-9965.epi-09-0372

Cited by 717Adipokines, Inflammation, and Metabolic DiseasesCancer Risks and FactorsAdipose Tissue and Metabolism

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Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

van Kruijsdijk, Rob C.M., van der Wall, Elsken, Visseren, Frank L.J.·2009·Cancer Epidemiology, Biomarkers & Prevention

DOI 10.1158/1055-9965.epi-09-0372

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Abstract

Overweight and obesity are health problems of epidemic proportions, increasing the risk not only of cardiovascular disease and type 2 diabetes mellitus but also of various types of cancer. Obesity is strongly associated with changes in the physiological function of adipose tissue, leading to insulin resistance, chronic inflammation, and altered secretion of adipokines. Several of these factors, such as insulin resistance, increased levels of leptin, plasminogen activator inhibitor-1, and endogenous sex steroids, decreased levels of adiponectin, and chronic inflammation, are involved in carcinogenesis and cancer progression. This article reviews these mechanisms, focusing on adipose tissue dysfunction as a unifying causal factor. Although understanding of the link between obesity and cancer might provide therapeutic targets, preventing overweight and obesity still remains number one priority.

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Adipose tissue is an active endocrine organ producing free fatty acids, IL-6, monocyte chemoattractant protein, PAI-1, adiponectin, leptin, and TNF-α.
“As recently reviewed, adipose tissue is an active endocrine organ producing free fatty acids, interleukin-6 (IL-6), monocyte chemoattractant protein, plasminogen activator inhibitor-1 (PAI-1), adiponectin, leptin, and tumor necrosis factor-α (69).”
From Diabetes and Cancer (2010) · cites this paper as [69]

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Adiponectin Suppression of High-Glucose–Induced Reactive Oxygen Species in Vascular Endothelial Cells
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Plasma leptin and colorectal cancer risk: A prospective study in Northern Sweden
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Reactive Oxygen-induced Carcinogenesis Causes Hypermethylation of p16Ink4a and Activation of MAP Kinase
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Targeting of Urokinase Plasminogen Activator Receptor in Human Pancreatic Carcinoma Cells Inhibits c-Met– and Insulin-like Growth Factor-I Receptor–Mediated Migration and Invasion and Orthotopic Tumor Growth in Mice
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Leptin Is Associated with an Increased Female Colorectal Cancer Risk: A Nested Case-Control Study in Japan
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Self-citation
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Insulin Regulation of Human Hepatic Growth Hormone Receptors: Divergent Effects on Biosynthesis and Surface Translocation
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The relationship between serum levels of insulin and sex hormone-binding globulin in men: the effect of weight loss
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Predictive Value of the Differential Expression of the Urokinase Plasminogen Activation Axis in Radical Prostatectomy Patients
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Interleukin-6-Related Genotypes, Body Mass Index, and Risk of Multiple Myeloma and Plasmacytoma
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Mitogenic and anti‐apoptotic actions of adipocyte‐derived hormone leptin in prostate cancer cells
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Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice
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Diabetes and Cancer
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Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer
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Insights on the Use of α-Lipoic Acid for Therapeutic Purposes
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Authors: van Kruijsdijk, R. C. M., van der Wall, E., & Visseren, F. L. J.
Affiliations: Departments of 1Vascular Medicine and 2Pathology and Medical Oncology, University Medical Center Utrecht, the Netherlands
University Medical Center Utrecht (NL)
Corresponding author: Visseren, Frank L.J.
ORCID: Visseren, Frank L.J.
Venue: Cancer Epidemiology, Biomarkers & Prevention
Publisher: American Association for Cancer Research (AACR)
Published: 2009-10-01
Volume: 18
Issue: 10
Pages: 2569-2578
ISSN: 1055-9965 (ISSN-L)
1538-7755
DOI: 10.1158/1055-9965.epi-09-0372
OpenAlex: W2152913697
Cited by: 715
References: 159
Citations by year: 2026: 11 · 2025: 18 · 2024: 24 · 2023: 35 · 2022: 37 · 2021: 49 · 2020: 36 · 2019: 53 · 2018: 52 · 2017: 58 · 2016: 40 · 2015: 65 · 2014: 55 · 2013: 70 · 2012: 49
FWCI: 4.57
Type: journal article
Language: en
Open access: closed
Locations: Cancer Epidemiology Biomarkers & Prevention (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Oncology › Cancer Risks and Factors
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords: obesity, cancer, adipose tissue dysfunction, insulin resistance, chronic inflammation, adipokines, leptin, plasminogen activator inhibitor-1, sex steroids, adiponectin, carcinogenesis, tumor progression, overweight prevention
MeSH terms: Adipose Tissue, Humans, Neoplasms, Obesity

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Obesity and Cancer: The Role of Dysfunctional Adipose Tissue

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