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Cited by 129Ovarian function and disordersAcne and Rosacea Treatments and EffectsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.

Insulin Sensitizers for the Treatment of Hirsutism: A Systematic Review and Metaanalyses of Randomized Controlled Trials

Cosma, Mihaela, Swiglo, Brian A., Flynn, David N., Kurtz, David M., LaBella, Matthew L., Mullan, Rebecca J., Elamin, Mohamed B., Erwin, Patricia J., Montori, Victor M.·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2007-2429
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Abstract

CONTEXT: Insulin sensitizers, including metformin and thiazolidinediones (TZDs), improve hyperinsulinemia and reproductive dysfunctions in some women with hyperandrogenism. The extent to which these agents improve hirsutism remains unclear. OBJECTIVE: Our objective was to conduct a systematic review and metaanalyses of randomized controlled trials of metformin or TZDs for the treatment of hirsutism. DATA SOURCES: We searched the following databases: MEDLINE, EMBASE, and Cochrane CENTRAL (up to May 2006). Review of reference lists and contact with hirsutism experts further identified candidate trials. STUDY SELECTION: Reviewers working independently and in duplicate, with acceptable chance-adjusted agreement (kappa = 0.72), determined trial eligibility. Eligible trials randomly assigned women with hirsutism to at least 6 months of insulin sensitizers or control and measured hirsutism outcomes. DATA EXTRACTION: Reviewers working independently and in duplicate determined the methodological quality of trials and collected data on patient characteristics, interventions, and outcomes. DATA SYNTHESIS: Of 348 candidate studies, 16 trials (22 comparisons) were eligible. The methodological quality of these trials was low. Random-effects metaanalyses showed a small decrease in Ferriman-Gallwey scores in women treated with insulin sensitizers compared with placebo [pooled weighted mean difference (WMD) of -1.5; 95% confidence interval (CI), -2.8 to -0.2; inconsistency (I(2)) = 75%]. There was no significant difference between insulin sensitizers and oral contraceptives (WMD of -0.5; CI, -5.0, 3.9; I(2) = 79%). Metformin was inferior to both spironolactone (WMD of 1.3; CI, 0.03, 2.6) and flutamide (WMD of 5.0; CI, 3.0, 7.0; I(2) = 0%). CONCLUSIONS: Imprecise and inconsistent evidence of low to very low quality suggests that insulin sensitizers provide limited or no important benefit for women with hirsutism.

Overview

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Crossref · 10.1210/jc.2007-2429

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Metadata

Authors
Cosma, M., Swiglo, B. A., Flynn, D. N., Kurtz, D. M., LaBella, M. L., Mullan, R. J., Elamin, M. B., Erwin, P. J., & Montori, V. M.
Affiliations
Mayo Clinic (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-04
Volume
93
Issue
4
Pages
1135-1142
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2007-2429
OpenAlex
W2103374510
Cited by
129
References
36
Citations by year
2025: 2 · 2024: 1 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 9 · 2014: 12 · 2013: 13 · 2012: 8
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hirsutism, insulin sensitizers, metformin, thiazolidinediones, hyperandrogenism, Ferriman-Gallwey score, oral contraceptives, spironolactone, flutamide, treatment efficacy
MeSH terms
Androgen Antagonists, Drug Therapy, Combination, Hirsutism, Humans, Hypoglycemic Agents, Metformin, Randomized Controlled Trials as Topic

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