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Cited by 148Ovarian function and disordersDiabetes, Cardiovascular Risks, and LipoproteinsGenetic and Kidney Cyst Diseases

Effects of Medical Therapy on Insulin Resistance and the Cardiovascular System in Polycystic Ovary Syndrome

Meyer, Caroline, McGrath, Barry P., Teede, Helena Jane·2007·Diabetes Care
DOI 10.2337/dc06-0618
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Abstract

Objective We aimed to determine the impact of medical therapy for symptom management on insulin resistance, metabolic profiles, and surrogate markers of cardiovascular disease in polycystic ovary syndrome (PCOS), an insulin-resistant pre-diabetes condition. Research design and methods One hundred overweight women (BMI >27 kg/m2), average age 31 years, who were nonsmokers, were not pregnant, did not have diabetes, and were off relevant medications for 3 months completed this 6-month open-label controlled trial. Randomization was to a control group (higher-dose oral contraceptive [OCP] 35 microg ethinyl estradiol [EE]/2 mg cyproterone acetate, metformin [1 g b.d.] or low-dose OCP [20 microg EE/100 microg levonorgestrel + aldactone 50 mg b.d.]). Primary outcome measures were insulin resistance (area under curve on oral glucose tolerance test) and surrogate markers of cardiovascular disease including arterial stiffness (pulse wave velocity [PWV]) and endothelial function. Results All treatments similarly and significantly improved symptoms including hirsutism and menstrual cycle length. Insulin resistance was improved by metformin and worsened by the high-dose OCP. Arterial stiffness worsened in the higher-dose OCP group (PWV 7.46 vs. 8.03 m/s, P Conclusions In overweight women with PCOS, metformin and low- and high-dose OCP preparations have similar efficacy but differential effects on insulin resistance and arterial function. These findings suggest that a low-dose OCP preparati…

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  • Metformin reduces insulin resistance in type 2 diabetes and in adults and adolescents with PCOS when hyperinsulinaemic euglycaemic clamps are used.

    “Metformin clearly reduces insulin resistance in DM2and in adults and adolescents with PCOS when hyperinsulinaemic euglycaemic clamps were used (Moghetti et al. , 2000; Meyer et al. , 2007; Arslanian et al. , 2002).”

    From Metformin and lifestyle modification in polycystic ovary syndrome: systematic review and meta-analysis (2015) · cites this paper as Meyer et al. , 2007

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Authors
Meyer, C., McGrath, B. P., & Teede, H. J.
Affiliations
  • Monash University (AU)
  • Jean Hailes (AU)
ORCID
Teede, Helena Jane
Venue
Diabetes Care
Publisher
American Diabetes Association
Published
2007-03-01
Volume
30
Issue
3
Pages
471-478
ISSN
  • 0149-5992 (ISSN-L)
  • 1935-5548
DOI
10.2337/dc06-0618
OpenAlex
W2045253522
Cited by
148
References
50
Citations by year
2025: 3 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 10 · 2014: 8 · 2013: 3 · 2012: 15
FWCI
19.15
Type
journal article
Language
en
Open access
closed
Locations
  • Diabetes Care (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, insulin resistance, metformin, oral contraceptives, cyproterone acetate, levonorgestrel, spironolactone, arterial stiffness, pulse wave velocity, endothelial function, cardiovascular risk, hirsutism, overweight women, prediabetes
MeSH terms
Adult, Cardiovascular Physiological Phenomena, Contraceptives, Oral, Female, Femoral Artery, Glucose Tolerance Test, Homeostasis, Humans, Insulin, Insulin Resistance, Metformin, Models, Biological, Polycystic Ovary Syndrome, Body Mass Index, Area Under Curve, Overweight

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