Cited by 682Bariatric Surgery and OutcomesDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 56 of the 57 references it cites were found in a registry or an index.

Effect of Weight Loss by Gastric Bypass Surgery Versus Hypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

Open access

Laferrère, Blandine, Teixeira, Julio, McGinty, James, Tran, Hao, Egger, Joseph R., Colarusso, Antonia, Kovack, Betty, Bawa, Baani, Koshy, Ninan, Lee, Hongchan, Yapp, Kimberly, Olivan, Blanca·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2007-2851PMC PMC2453054

Open this paper in CoChat — free account

Abstract

CONTEXT: Gastric bypass surgery (GBP) results in rapid weight loss, improvement of type 2 diabetes (T2DM), and increase in incretins levels. Diet-induced weight loss also improves T2DM and may increase incretin levels. OBJECTIVE: Our objective was to determine whether the magnitude of the change of the incretin levels and effect is greater after GBP compared with a low caloric diet, after equivalent weight loss. DESIGN AND METHODS: Obese women with T2DM studied before and 1 month after GBP (n = 9), or after a diet-induced equivalent weight loss (n = 10), were included in the study. Patients from both groups were matched for age, body weight, body mass index, diabetes duration and control, and amount of weight loss. SETTING: This outpatient study was conducted at the General Clinical Research Center. MAIN OUTCOME MEASURES: Glucose, insulin, proinsulin, glucagon, gastric inhibitory peptide (GIP), and glucagon-like peptide (GLP)-1 levels were measured after 50-g oral glucose. The incretin effect was measured as the difference in insulin levels in response to oral and to an isoglycemic iv glucose load. RESULTS: At baseline, none of the outcome variables (fasting and stimulated values) were different between the GBP and diet groups. Total GLP-1 levels after oral glucose markedly increased six times (peak:17 +/- 6 to 112 +/- 54 pmol/liter; P < 0.001), and the incretin effect increased five times (9.4 +/- 27.5 to 44.8 +/- 12.7%; P < 0.001) after GBP, but not after diet. Postprandial glucose levels (P = 0.001) decreased more after GBP. CONCLUSIONS: These data suggest that early after GBP, the greater GLP-1 and GIP release and improvement of incretin effect are related not to weight loss but rather to the surgical procedure. This could be responsible for better diabetes outcome after GBP.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1210/jc.2007-2851

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Bariatric Surgery: A Systematic Review and Meta-analysis
Buchwald, H., Avidor, Y., Braunwald, E., Jensen, M. D., Pories, W., Fahrbach, K., & Schoelles, K. (2004) · JAMA · doi:10.1001/jama.292.14.1724 · Cited by 6,800
Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002.
Hedley, A. A., Ogden, C., Johnson, C. L., Carroll, M., Curtin, L. R., & Flegal, K. (2004) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.291.23.2847 · Cited by 4,670
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Reduced incretin effect in Type 2 (non-insulin dependent) diabetes
Nauck, M., Stöckmann, F., Ebert, R., & Creutzfeldt, W. (1986) · Diabetologia · doi:10.1007/bf02427280 · Cited by 1,307
Gut Hormone Profiles Following Bariatric Surgery Favor an Anorectic State, Facilitate Weight Loss, and Improve Metabolic Parameters
Roux, C. W. L., Aylwin, S. J. B., Batterham, R. L., Borg, C. M., Coyle, F., Prasad, V., Shurey, S., Ghatei, M. A., Patel, A. G., & Bloom, S. R. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000183349.16877.84 · Cited by 985
Plasma Insulin Responses to Oral and Intravenous Glucose: Studies in Normal and Diabetic Subjects*
Perley, M. J., & Kipnis, D. M. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105685 · Cited by 917
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
NAUCK, M. A., HOMBERGER, E., SIEGEL, E. G., ALLEN, R. C., EATON, R. P., EBERT, R., & CREUTZFELDT, W. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-2-492 · Cited by 874
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
Toft-Nielsen, M.-B., Damholt, M. B., Madsbad, S., Hilsted, L. M., Hughes, T. E., Michelsen, B. K., & Holst, J. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7750 · Cited by 869
Trends in mortality in bariatric surgery: a systematic review and meta-analysis
Buchwald, H., Estok, R., Fahrbach, K., Banel, D., & Sledge, I. (2007) · Surgery · doi:10.1016/j.surg.2007.07.018 · Cited by 685
Reduction in Incidence of Diabetes, Hypertension and Lipid Disturbances after Intentional Weight Loss Induced by Bariatric Surgery: the SOS Intervention Study
Sjöström, C. D., Lissner, L., Wedel, H., & Sjöström, L. (1999) · Obesity Research · doi:10.1002/j.1550-8528.1999.tb00436.x · Cited by 685

Show all 57 references

Research works printed but not linked: 1

Laferrère, 2007, The increase in GLP-1 levels and incretin effect after Roux-en-Y gastric bypass surgery (RYGBP) persists up to 1 year in patients with type 2 diabetes mellitus (T2DM), Obesity, 15, 7

Sorted by citations

Items 401–500 of 678

Temporal plasticity of insulin and incretin secretion and insulin sensitivity following sleeve gastrectomy contribute to sustained improvements in glucose control
Douros, J. D., Niu, J., Sdao, S. M., Gregg, T., Merrins, M. J., Campbell, J. E., Tong, J., & D’Alessio, D. A. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.07.003 · Cited by 13
Mechanisms of type 2 diabetes resolution after Roux-en-Y gastric bypass
Elahi, D., Galiatsatos, P., Rabiee, A., Salas-Carrillo, R., Vakilipour, A., Carlson, O. D., Angeli, F. S., Shannon, R. P., Egan, J. M., & Andersen, D. K. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.07.011 · Cited by 13
“Numerous studies have confirmed this assertion [10–17], and other studies [16,18] have suggested that bariatric surgery should be considered as a treatment modality for the resolution of T2 DM regardless of body mass index (BMI).”
GLP-1—A Candidate Humoral Mediator for Glucose Control After Roux-en-Y Gastric Bypass
Schirra, J. R. J., & Göke, B. (2014) · Diabetes · doi:10.2337/db13-1660 · Cited by 13
“like peptide-1-(7-37) appears not to augment insulin-mediated glucose”
BackgroundInfluential
Surgery for Diabetes: Clinical and Mechanistic Aspects
Kapeluto, J., Tchernof, A., & Biertho, L. D. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.05.008 · Cited by 15
“At 1 month, dietary caloric restriction showed a nonsignificant decrease in GLP-1 levels but similar fasting, AUC and peak insulin responses to glucose challenge when compared to RYGB (36).”
BackgroundResult
Bariatric Surgery and Liver Transplantation.
Suraweera, D., Saab, E. G., Choi, G., & Saab, S. (2017) · Europe PMC (PubMed Central) · Cited by 13
Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery
Guldstrand, M., Åhrén, B., Näslund, E. B., Holst, J. J., & Adamson, U. (2009) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2009.01089.x · Cited by 13
Effectiveness of beinaglutide in a patient with late dumping syndrome after gastrectomy: A case report
Ding, B., Hu, Y., Yuan, L., Yan, R.-N., & Ma, J.-H. (2021) · Medicine · doi:10.1097/md.0000000000026086 · Cited by 13
“Accelerated gastric emptying plays an important role in the pathogenesis of late dumping syndrome after gastric surgery, it gives rise to a larger and earlier increase in plasma glucose, insulin, GLP-1, and GIP concentrations, and thus to reactive hypoglycemia.([3,8]) GLP-1RAs can reduce gastric emptying, which leads…”
Background
Gastric Bypass and Influence on Improvement of NAFLD
Alli, V. V., & Rogers, A. M. (2017) · Current Gastroenterology Reports · doi:10.1007/s11894-017-0567-8 · Cited by 12
Three-year result of efficacy for type 2 diabetes mellitus control between laparoscopic duodenojejunal bypass compared with laparoscopic Roux-en-Y gastric bypass
Kim, D. J., Paik, K. Y., Kim, M. K., Kim, E., & Kim, W. (2017) · Annals of Surgical Treatment and Research · doi:10.4174/astr.2017.93.5.260 · Cited by 12
“These early antidiabetic effects are explained by increased levels of incretin hormones, such as glucagon-like peptide-1 or gastric inhibitory polypeptide [7].”
Background
Small intestinal physiology relevant to bariatric and metabolic endoscopic therapies: Incretins, bile acid signaling, and gut microbiome
van Olst, N., Meiring, S., de Brauw, M., Bergman, J. J. G. H. M., Nieuwdorp, M., van der Peet, D. L., & Gerdes, V. E. A. (2020) · Techniques and Innovations in Gastrointestinal Endoscopy · doi:10.1016/j.tige.2020.03.003 · Cited by 12
The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes
Otten, J., Stomby, A., Waling, M. U., Chorell, E., Ryberg, M., Svensson, M., Holst, J. J., & Olsson, T. (2021) · Endocrine Connections · doi:10.1530/ec-21-0171 · Cited by 12
Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis
Gao, Z., Yang, J., Liang, Y., Yang, S., Zhang, T., Gong, Z., & Li, M. (2022) · Obesity Surgery · doi:10.1007/s11695-022-05959-4 · Cited by 13
Full and durable remission of type 2 diabetes? Through surgery?
Pories, W. J., & Dohm, G. L. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2008.12.006 · Cited by 12
Worthy or not? Six-year experience of revisional bariatric surgery from an Asian center of excellence
Vij, A., Malapan, K., Tsai, C., Hung, K.-C., Chang, P., & Huang, C. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2014.04.033 · Cited by 12
“They also exhibit an enhanced sensitivity to these hormones as a result of changes in the entero-insular axis and the “incretin effect,” which may not completely respond to mechanical intervention alone [27].”
Background
Surgical Therapy for Diabesity
Arroyo, K., Kini, S. U., Harvey, J. E., & Herron, D. M. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20209 · Cited by 13
Effects of meal composition on postprandial incretin, glucose and insulin responses after surgical and medical weight loss
Lee, C. J., Brown, T. T., Cheskin, L. J., Choi, P. P., Moran, T. H., Peterson, L., Matuk, R., & Steele, K. E. (2015) · Obesity Science & Practice · doi:10.1002/osp4.17 · Cited by 12
Sleeve gastrectomy in obese Wistar rats improves diastolic function and promotes cardiac recovery independent of weight loss
Hayes, H., Patz, J., Corbett, J. A., Afzal, M. Z., Strande, J. L., & Kindel, T. L. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2019.03.036 · Cited by 12
“This mirrors clinical findings were post-prandial GLP-1 levels are uniquely increased after bariatric surgery unlike dieting (22).”
High‐Resolution Three‐Dimensional Photonic Scan‐Derived Equations Improve Body Surface Area Prediction in Diverse Populations
Ashby‐Thompson, M., Ji, Y., Wang, J., Yu, W. L., Thornton, J. C., Wolper, C., Weil, R. M., Chambers, E. C., Laferrère, B., Pi-Sunyer, X., et al. (2020) · Obesity · doi:10.1002/oby.22743 · Cited by 12
“Cross-sectional data from a convenience sample of individuals who had participated in one of three studies conducted at St. Luke’s– Roosevelt Hospital’s Body Composition Unit (15-19) were used for the analyses.”
Duodenal-Jejunal Bypass Liner to Treat Type 2 Diabetes Mellitus in Morbidly Obese Patients
Muñoz, R., & Escalona, A. (2014) · Current Cardiology Reports · doi:10.1007/s11886-013-0454-3 · Cited by 12
Gastric Bypass vs Diet and Cardiovascular Risk Factors
Karlsson, C., Johnson, L. K., Greasley, P. J., Retterstøl, K., Hedberg, J., Hall, M., Hawker, N., Robertsen, I., Havsol, J., Hertel, J. K., et al. (2024) · JAMA Surgery · doi:10.1001/jamasurg.2024.2162 · Cited by 11
Chirurgie als pluripotentes Instrument gegen eine metabolische Erkrankung
Corteville, C., Faßnacht, M., & Bueter, M. (2014) · Der Chirurg · doi:10.1007/s00104-014-2796-9 · Cited by 11
Alterations in Proinsulin and Insulin Dynamics, HDL Cholesterol and ALT After Gastric Bypass Surgery. A 42-Months Follow-up Study
Johansson, H.-E., Haenni, A., Öhrvall, M., Sundbom, M., & Zethelius, B. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9806-x · Cited by 11
“A recent pilot study including T2DM patients, followed up 1 month after RYGBP, reported that fasting proinsulin was lowered, but not normalized, from 32 to 19 pmol/l already after 1 month [ 30 ].”
Background
Secretin as a Satiation Whisperer With the Potential to Turn into an Obesity-curbing Knight
Schnabl, K., Li, Y., U-Din, M., & Klingenspor, M. (2021) · Endocrinology · doi:10.1210/endocr/bqab113 · Cited by 11
Differential effects of RYGB surgery and best medical treatment for obesity-diabetes on intestinal and islet adaptations in obese-diabetic ZDSD rats
Sridhar, A., Khan, D., Abdelaal, M., Elliott, J. A., Naughton, V. R., Flatt, P. R., le Roux, C. W., Docherty, N. G., & Moffett, R. C. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274788 · Cited by 11
Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions
Thaker, V., Kwee, L. C., Chen, H., Bahnson, J. L., Ilkayeva, O., Muehlbauer, M. J., Wolfe, B. M., Purnell, J. Q., Pi-Sunyer, X., Newgard, C. B., et al. (2023) · Obesity · doi:10.1002/oby.23943 · Cited by 11
“The partial or complete remission of T2D with weight loss has been demonstrated with both intensive lifestyle intervention (ILI) [8] and metabolic-bariatric surgery (MBS) [9], with a higher proportion in those undergoing MBS [10, 11].”
BackgroundInfluential
Protocol for a randomised clinical study comparing the effect of Roux-en-Y gastric bypass and sleeve gastrectomy on reactive hypoglycaemia in morbidly obese subjects
Mingrone, G., Panunzi, S., Gaetano, A. D., Guidone, C., Raffaelli, M., Callari, C., Lombardi, P., & Bellantone, R. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-002184 · Cited by 12
Cirurgia metabólica: mudanças na anatomia gastrointestinal e a remissão do diabetes mellitus tipo 2
COHEN, R. V., Torres, M. C., & Schiavon, C. A. (2010) · ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) · doi:10.1590/s0102-67202010000100010 · Cited by 10
Tissue specificity in fasting glucose utilization in slightly obese diabetic patients submitted to bariatric surgery
Morbelli, S. D., Marini, C., Adami, G. F., Kudomi, N., Camerini, G. B., Iozzo, P., Massollo, M., Capitanio, S., Bodrato, S., Verardi, M. T., et al. (2013) · Obesity · doi:10.1002/oby.20003 · Cited by 11
“Undoubtedly, weight reduction (27) largely contributes to the improved IR with mechanisms that have been described in the course of dietary caloric restriction (32).”
Background
Weight versus weight-independent effects of Roux-en-Y gastric bypass on type 2 diabetes
Klein, S., & Seeley, R. J. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00823-w · Cited by 10
Roux-en-Y and One-Anastomosis Gastric Bypass Surgery Are Superior to Sleeve Gastrectomy in Lowering Glucose and Cholesterol Levels Independent of Weight Loss: a Propensity-Score Weighting Analysis
Chang, Y., Hsu, C., Chong, K., Yang, P., Ser, K., Lee, P., Chen, S., Hsuan, C., Lee, Y.-C., Hsu, C., et al. (2023) · Obesity Surgery · doi:10.1007/s11695-023-06656-6 · Cited by 11
Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single‐photon emission computed tomography (SPECT) studies
Al‐Alsheikh, A. S., Alabdulkader, S., Miras, A. D., & Goldstone, A. P. (2023) · Obesity Reviews · doi:10.1111/obr.13620 · Cited by 10
“182,183 Post-oral glucose plasma GLP-1 increased after RYGB surgery for obesity with T2DM, but not after matched weight loss from LCD. 184 In addition, despite similar weight loss, fasting and post-prandial acyl ghrelin may decrease more after VSG than RYGB surgery, while post-prandial plasma PYY…”
Background
Bariatric Surgery and Bone Loss: Do We Need to Be Concerned?
Brzozowska, M. M., Sainsbury, A., Eisman, J. A., & Baldock, P. A. J. (2014) · Clinical Reviews in Bone and Mineral Metabolism · doi:10.1007/s12018-014-9162-9 · Cited by 10
“Post-surgical increases in postprandial GLP-1 have been documented following RYGB [150, 155].”
Background
Recovery of the Incretin Effect in Type 2 Diabetic Patients After Biliopancreatic Diversion
Novaes, F. S., Vasques, A. C. J., Pareja, J. C., Knop, F. K., Tura, A., Chaim, É. A., & Geloneze, B. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4042 · Cited by 10
Secretion and Function of Gastrointestinal Hormones after Bariatric Surgery: Their Role in Type 2 Diabetes
Shukla, A. P., & Rubino, F. (2011) · Canadian Journal of Diabetes · doi:10.1016/s1499-2671(11)52008-8 · Cited by 10
GK-rats respond to gastric bypass surgery with improved glycemia despite unaffected insulin secretion and beta cell mass
Miskelly, M. G., Shcherbina, L., Fischer, A.-H. T., Abels, M., Lindqvist, A., & Wierup, N. (2020) · Peptides · doi:10.1016/j.peptides.2020.170445 · Cited by 10
“increased GLP-1 response is suggested in multiple studies as the trigger for the well established increased postprandial insulin response after RYGB [10,20,22].”
Bariatric Surgery: Effects on the Metabolic Complications of Obesity
Clifton, P. M. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0231-6 · Cited by 10
Alterações dos parâmetros clínicos e laboratoriais em pacientes obesos com diabetes melito tipo 2 submetidos à derivação gastrojejunal em y de Roux sem anel
Varaschim, M., Nassif, P. A. N., Moreira, L. B., do Nascimento, M. M., Vieira, G. M. N., Garcia, R. F., Sue, K. M., & Cruz, M. A. (2012) · Revista do Colégio Brasileiro de Cirurgiões · doi:10.1590/s0100-69912012000300003 · Cited by 10
Bariatric surgery: An IDF statement for obese Type 2 diabetes
Dixon, J. B., Zimmet, P., Alberti, K. G. M. M., & Rubino, F. (2011) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2011.07.002 · Cited by 10
Gastrointestinal Endocrinology in Bariatric Surgery
Wabitsch, M. (2017) · Endocrine development · doi:10.1159/000475735 · Cited by 11
Early glycemic control and incretin improvement after gastric bypass: the role of oral and gastrostomy route
Fernandes, G. S. D. S., Santo, M. A., Crespo, A. D. F. C. B., Biancardi, G. B., Filippe Camarotto, M. O. T. A., Antonângelo, L., & de Cleva, R. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2019.01.013 · Cited by 10
Comparative impact of Roux-en-Y gastric bypass, sleeve gastrectomy or diet alone on beta-cell function in insulin-treated type 2 diabetes patients
Lannoo, M., Simoens, C., Vangoitsenhoven, R., Gillard, P., D’Hoore, A. J. L., Vadder, M. D., Mertens, A. C., Deleus, E., Steenackers, N., Mathieu, C., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-59048-w · Cited by 12
“By doing so, the well-characterized changes in glucose fluctuations and incretin hormones are circumvented that occur in response to oral stimuli elicited by an OGTT or MMTT after RYGB and SG 9,10,36,38,39 .”
BackgroundMethodInfluential
Cirurgia metabólica: cura para diabete tipo 2
Zeve, J. L. D. M., & Tomaz, C. A. B. (2011) · ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) · doi:10.1590/s0102-67202011000400012 · Cited by 10
Pathogenesis of Type 2 Diabetes
Alsahli, M., & Gerich, J. E. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1028-7_7 · Cited by 8
Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R
Choong, Y. S., Lim, Y. Y., Soong, J. X., Savoo, N., Guida, C., Rhyman, L., Ramracheya, R. D., & Ramasami, P. (2021) · HORMONES · doi:10.1007/s42000-021-00278-2 · Cited by 9
“A comparison between the effects of bariatric surgery and weight loss through diet emphasized that the improvement of glucose homeostasis is not related to weight loss [3].”
Background
AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters
Andrade-Silva, S. G., Caranti, D. A., Sallet, J. A. A. S., Leal, L. P. F. F., Antonio Joaquim Ferreira, L. E. A. L., & Dâmaso, A. R. (2014) · Arquivos de Gastroenterologia · doi:10.1590/s0004-2803201400030002 · Cited by 9
“The new anatomy of the digestive system after surgery favors a secretion of GLP-1, the trigger for the improvement of glucose metabolism(24, 26, 27, 38, 40, 53).”
Background
Defending a new hypothesis of how bariatric surgery works
Frikke‐Schmidt, H., & Seeley, R. J. (2016) · Obesity · doi:10.1002/oby.21444 · Cited by 9
“A growing body of evidence argues against restriction and malabsorption as key drivers of surgical weight loss as it would contradict findings such as: 1) in rodent models, animals with bariatric surgery are capable of increasing their food intake to meet metabolic needs during pregnancy (2) or after food restriction…”
Result
Physiologic Mechanisms of Weight Loss Following Metabolic/Bariatric Surgery
Luo, J. N., & Tavakkoli, A. (2021) · Surgical Clinics of North America · doi:10.1016/j.suc.2020.12.006 · Cited by 9
Pulmonary function and blood gases after gastric bypass and lifestyle intervention: a comparative study
Gabrielsen, A.-M., Lund, M. B., Kongerud, J. S., Viken, K. E., Røislien, J., Hjelmesaeth, J. S., & Hofsø, D. (2013) · Clinical Obesity · doi:10.1111/cob.12024 · Cited by 9
“Glucagon-like peptide 1 (GLP-1) is a hormone produced in the intestinal epithelial endocrine L-cells that increases after gastric bypass surgery but not after diet-induced weight loss (28).”
Background
Dietary reversal of Type 2 diabetes motivated by research knowledge
Steven, S., Lim, E. L., & Taylor, R. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.02992.x · Cited by 9
Subcutaneous adipose tissue and skeletal muscle mitochondria following weight loss
van der Kolk, B. W., Pirinen, E., Nicoll, R., Pietiläinen, K. H., & Heinonen, S. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.08.002 · Cited by 8
THE ROLE OF METABOLIC SURGERY FOR PATIENTS WITH OBESITY GRADE I ANDCLINICALLY UNCONTROLLED TYPE 2 DIABETES
Campos, J. M., RAMOS, A. C., SZEGO, T., Zilberstein, B., Neto, H. F. E. C., & COHEN, R. V. (2016) · ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) · doi:10.1590/0102-67202016nahead0001 · Cited by 8
Laparoscopic sleeve gastrectomy leads to rapid improvement of glucose tolerance and insulin secretion with enhanced glucagon-like peptide (GLP-1) secretion
Ugi, S., Yamamoto, H., 楠知里, Kamo, A., Ikeda, K., Hashimoto, T., Nishio, Y., Kasama, K., Tani, T., Kashiwagi, A., et al. (2010) · Diabetology International · doi:10.1007/s13340-010-0011-x · Cited by 8
“In fact, it has been previously shown that caloric restriction does not improve GLP-1 secretion [12].”
Background
The Correlation Between Intestinal Gonadotropin-Releasing Hormone (GnRH) and Proglucagon in Hyperlipidemic Rats and Goto-Kakizaki (GK) Rats
Wang, L., Wu, J., Cao, H., Chen, R., Zhang, N., Fu, J., Gao, B., Zhang, J., Hou, R., Tang, C.-W., et al. (2009) · Endocrine Pathology · doi:10.1007/s12022-009-9086-y · Cited by 8
“Recent study demonstrated that earlier after gastric bypass surgery (GBP), the greater GLP-1 and GIP release, and improvement of incretin effect are related not to weight loss but rather to the surgical procedure [ 8 ].”
Background
Differential effect of gastric bypass versus sleeve gastrectomy on insulinotropic action of endogenous incretins
Salehi, M., Peterson, R., Tripathy, D., Pezzica, S., DeFronzo, R. A., & Gastaldelli, A. (2023) · Obesity · doi:10.1002/oby.23872 · Cited by 11
“Postprandial hyperinsulinemia in GB has been attributed to the combined effects of elevated glucose [8, 10] and a larger incretin effect [5, 13, 18] whereas the role of the incretin effect after SG is less characterized.”
Background
Electrical stimulation of the isolated rat intestine in the presence of nutrient stimulus enhances glucagon-like peptide-1 release
Schwartz, A., Ort, T., Kajekar, R., Wade, P. R., & Hornby, P. J. (2010) · Physiological Measurement · doi:10.1088/0967-3334/31/9/006 · Cited by 8
Bariatric surgery as a treatment option in patients with type 2 diabetes mellitus
Spanou, M. (2013) · World Journal of Diabetes · doi:10.4239/wjd.v4.i2.14 · Cited by 8
Durable remission of diabetes after bariatric surgery: What is the underlying pathway?
Wilson, J. B., & Pories, W. J. (2010) · Insulin · doi:10.1016/s1557-0843(10)80009-0 · Cited by 8
Bariatrische Chirurgie
Hüttl, T. P., Kramer, K. M., & Wood, H. (2010) · Der Diabetologe · doi:10.1007/s11428-010-0611-x · Cited by 8
Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function
Alkandari, A., Ashrafian, H., Sathyapalan, T., Darzi, A. W., Holmes, E. C., Athanasiou, T., Atkin, S. L., & Gooderham, N. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00319 · Cited by 8
“These improvements are observed early post-operatively, before substantial weight loss and to a greater extent than in patients who achieve similar weight loss non-surgically, and are therefore, thought to offer weight-independent metabolic effects (20, 21) in addition to weight-dependent metabolic actions.”
Background
From Entero-Endocrine Cell Biology to Surgical Interventional Therapies for Type 2 Diabetes
Guimarães, M., Pereira, S. S., & Monteiro, M. P. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_480 · Cited by 8
Evidências e dúvidas sobre o tratamento cirúrgico do diabetes tipo 2
Ceneviva, R., Viegas-Silva, M. M., dos Santos, J. S., Salgado, W., & Júnior, O. C. E. S. (2011) · Medicina (Ribeirão Preto) · doi:10.11606/issn.2176-7262.v44i4p402-413 · Cited by 7
Portal milieu and the interplay of multiple antidiabetic effects after gastric bypass surgery
Pal, A., Rhoads, D. B., & Tavakkoli, A. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00389.2018 · Cited by 9
“Clinical studies have identified increased incretin levels in the early weight-independent and diet-independent effects of RYGB (15, 16), and reduced incretin levels after RYGB may play a role in weight regain and diabetes relapse (31).”
Background
Partial restoration of normal intestinal microbiota in morbidly obese women six months after bariatric surgery
Koffert, J., Lahti, L., Nylund, L., Salminen, S., Hannukainen, J. C., Salminen, P. T. P., de Vos, W. M., & Nuutila, P. (2020) · PeerJ · doi:10.7717/peerj.10442 · Cited by 8
“However, reduced food ingestion, increased satiety, increased gastric emptying and shift in bile acid metabolism have been suggested to have a role (Laferrere et al., 2008; Plum et al., 2011).”
Background
Chirurgie als pluripotentes Instrument gegen eine metabolische Erkrankung
Corteville, C., Faßnacht, M., & Bueter, M. (2014) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-171966 · Cited by 7
Caloric restriction improves glycaemic control without reducing plasma branched-chain amino acids or keto-acids in obese men
Sayda, M. H., Aziz, M. H. A., Gharahdaghi, N., Wilkinson, D. J., Greenhaff, P. L., Phillips, B. E., Smith, K., IDRIS, I. R., & Atherton, P. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-21814-z · Cited by 8
A Brief History of the Surgery for Obesity to the Present, with an Overview of Nutritional Implications
Deitel, M. (2013) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.797854 · Cited by 7
“After operations that result in rapid entry of nutrients into the lower ileum (JI bypass, gastric bypass, and duodenal switch), resolution of T2D occurs in about 80% of patients [24,25].”
Background
Treating type 2 diabetes: incretin mimetics and enhancers
Janosz, K. E. N., Zalesin, K. C., Miller, W. M., & McCullough, P. A. (2009) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944709341377 · Cited by 7
“In a recent study by Laferrere et al. the Roux-en-Y gastric bypass procedure was noted to augment incretin release [Laferrere et al. 2008].”
Surgical Approaches for the Prevention and Treatment of Type 2 Diabetes Mellitus
Coffin, S. T., Konduru, C., Schwarcz, M., & Frishman, W. H. (2009) · Cardiology in Review · doi:10.1097/crd.0b013e3181bc23d1 · Cited by 7
“Lower levels of gherlin (increase appetite) and increased postprandial peptide YY may also occur to enhance diabetes control.(48,49) Two principal theories explain the possible mechanism of resolution of diabetes after bariatric procedure: the foregut and hindgut theory.”
Background
Low levels of C-peptide may not be a sign of pancreatic β-cell death or apoptosis: New insight into pancreatic endocrine function and indications for metabolic surgery
COHEN, R. V., Petry, T. B. Z., & Caravatto, P. P. D. P. (2013) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.08.004 · Cited by 7
“[19] Laferrère B, Teixeira J, McGinty J, et al.”
Background
Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects
Rigda, R. S., Trahair, L. G., Little, T. J., Wu, T., Standfield, S., Feinle‐Bisset, C., Rayner, C. K., Horowitz, M., & Jones, K. L. (2016) · Peptides · doi:10.1016/j.peptides.2016.10.010 · Cited by 7
Possibilities of metabolic surgery for the treatment of type 2 diabetes mellitus in patients with grade 1 alimentary obesity
Салухов, В. В., Ilinskii, N. S., Vasiliev, E. V., Sardinov, R. T., & Gladyshev, D. V. (2018) · Diabetes Mellitus · doi:10.14341/dm9292 · Cited by 7
Roux-en-Y Gastric Bypass Is Associated With Hyperinsulinemia But Not Increased Maximal β-Cell Function
Georgia, A., Asnis, M. C. C., Febres, G., Tsang, A., Bessler, M., & Körner, J. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2018-00213 · Cited by 7
“An interesting finding in this and other studies is that both the RYGB and the obese control groups had higher fasting levels of glucagon than the nonobese controls; however, unique to the RYGB group was a sustained postprandial elevation of glucagon levels that was greater than in BMI-matched controls [25, 27, 28, 36…”
Result
Proposed treatment strategy for reactive hypoglycaemia
Younes, Y. R., Cron, N., Field, B. C. T., Nayyar, V., Clark, J., Zachariah, S., Lakshmipathy, K., Isuga, J., Maghsoodi, N., & Emmanuel, J. J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1332702 · Cited by 6
“The condition is believed to result from accelerated gastric emptying causing hyperglycaemic peaks and excessive release of the incretin hormones, GLP-1 and GIP, resulting in hyperinsulinemia (4, 5).”
Background
The effect of distal-ileal exclusion after Roux-en-Y gastric bypass on glucose tolerance and GLP-1 response in type-2 diabetes Sprague-Dawley rat model
Dolo, P. R., Li, C., Zhu, X., Yao, L., Song, M., & Hong, J. (2018) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2018.07.009 · Cited by 6
Physiology Reconfigured: How Does Bariatric Surgery Lead to Diabetes Remission?
Albaugh, V. L., Axelrod, C. L., Belmont, K. P., & Kirwan, J. P. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2022.06.003 · Cited by 7
Molecular Changes in Cells of Patients with Type 2 Diabetes Mellitus Depending on Changes in Glycemia Level in the Context of Lifestyle—An Overview of the Latest Scientific Discoveries
Szczechla, M., Balewska, A., Naskręt, D., Zozulińska‐Ziółkiewicz, D., & Uruska, A. A. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45030126 · Cited by 8
Type 2 diabetes mellitus control and atherosclerosis prevention in a non-obese rat model using duodenal-jejunal bypass
Xuan, C., Huang, Z., Ran, W., Liao, G., Zha, L., & Wang, Z. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1832 · Cited by 6
“GBP may primarily contribute to the reduction of blood glucose levels in patients with T2DM rather than the control of weight (22-24).”
Does Caloric Restriction Alone Explain the Effects of Roux-en-Y Gastric Bypass on Glucose Metabolism? Not by a Long Limb
Vella, A. V. (2013) · Diabetes · doi:10.2337/db13-0806 · Cited by 6
“In an intact upper gastrointestinal tract, GLP-1 also delays gastric emptying (5) and increases gastric accommodation (6).”
BackgroundInfluential
An Optimized IES Method and Its Inhibitory Effects and Mechanisms on Food Intake and Body Weight in Diet-Induced Obese Rats: IES for Obesity
Wan, X., Yin, J., Foreman, R. D., & Chen, J. D. Z. (2017) · Obesity Surgery · doi:10.1007/s11695-017-2743-1 · Cited by 6
Pharmacist-led therapeutic carbohydrate restriction as a treatment strategy for type 2 diabetes: the Pharm-TCR randomized controlled trial protocol
Durrer, C. G., McKelvey, S., Singer, J., Batterham, A. M., Johnson, J. D., Wortman, J., & Little, J. P. (2019) · Trials · doi:10.1186/s13063-019-3873-7 · Cited by 6
Dipeptidyl peptidase-4 activity, lipopolysaccharide, C-reactive protein, glucose metabolism, and gut peptides 3 months after bariatric surgery
Braga, T. G., de Souza, M. D. G. C., Menezes, M., Neto, J. F. N., Dellatorre‐Teixeira, L., Bouskela, E., le Roux, C. W., & Kraemer‐Aguiar, L. G. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.08.030 · Cited by 7
Which predictors could effect on remission of type 2 diabetes mellitus after the metabolic surgery: A general perspective of current studies?
Akkuş, G., & Tetıker, T. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i8.1312 · Cited by 6
ESTADO NUTRICIONAL E AS COMORBIDADES ASSOCIADAS AO DIABETES MELLITUS TIPO 2 NO IDOSO
Tatsch, C. G., Fischer, M. D. Q., & Poll, F. A. (2016) · Estudos Interdisciplinares sobre o Envelhecimento · doi:10.22456/2316-2171.59049 · Cited by 6
Proinsulin associates with poor β‐cell function, glucose‐dependent insulinotropic peptide, and insulin resistance in persistent type 2 diabetes after Roux‐en‐Y gastric bypass in humans
Patel, K., Levesque, K., Mark, V., Pierini, E., Rojas, B., Ahlers, M. J., Shah, A. M., & Laferrère, B. (2019) · Journal of Diabetes · doi:10.1111/1753-0407.12964 · Cited by 6
“However, GLP-1 may be only one of many mediators of glucose control after RYGB, because the infusion of the GLP-1 receptor inhibitor exendin (9-39) worsens postprandial glucose only minimally after RYGB.”
Background
Obesity and the need for bariatric surgery in P akistan
Shah, A. A., & Shariff, A. H. (2013) · Asian Journal of Endoscopic Surgery · doi:10.1111/ases.12048 · Cited by 6
β-Cell Function After Weight-Loss Induced by Bariatric Surgery
Vella, A. V. (2014) · Physiology · doi:10.1152/physiol.00003.2014 · Cited by 6
Simultaneous pancreas-kidney (SPK) and pancreas living-donor kidney (SPLK) transplantation at the University of Maryland.
Philosophe, B., Farney, A. C., Schweitzer, E. J., Colonna, J. O., Jarrell, B. E., Foster, C., Wiland, A., & Bartlett, S. T. (2000) · PubMed · Cited by 6
Going With the Flow: Adaptation of β-Cell Function to Glucose Fluxes After Bariatric Surgery
Salehi, M., & D’Alessio, D. A. (2013) · Diabetes · doi:10.2337/db13-1213 · Cited by 5
Preintervention Clinical Determinants and Measured β-Cell Function as Predictors of Type 2 Diabetes Remission After Roux-en-Y Gastric Bypass Surgery
Ligon, C., Shah, A. M., PRASAD, M. A., & Laferrère, B. (2021) · Diabetes Care · doi:10.2337/dc21-0395 · Cited by 5
¿Es la diabetes mellitus tipo 2 una enfermedad de tratamiento quirurgico?
Rosero, G. (2010) · Revista Colombiana de Cirugía · Cited by 5
The role of obestatin in roux‐en‐Y gastric bypass‐induced remission of type 2 diabetes mellitus
Wang, J., Xu, X.-H., Zhang, X., & Li, W. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2735 · Cited by 5
“not only significantly reduced plasma glucose levels after 50 g oral glucose tolerance test (OGTT) but also decreased OGTT-induced plasma glucose excursions as compared with subjects in the diet group [25].”
Method
Typ-II-Diabetes
Pories, W. J. (2009) · Der Chirurg · doi:10.1007/s00104-009-1716-x · Cited by 4
Endocrine and metabolic aspects of the management of patients undergoing bariatric surgery. Review of clinical recommendations.
Mazurina, N. V., & Sviridonova, M. A. (2012) · Obesity and metabolism · doi:10.14341/2071-8713-5060 · Cited by 4
Post-Gastric Bypass Hypoglycemia: Diagnosis and Management
Fischer, L. E., Davis, D. B., Khoraki, J., & Campos, G. M. (2016) · Springer eBooks · doi:10.1007/978-3-319-27114-9_21 · Cited by 4
Obesity
Klein, S., Fabbrini, E., & Romijn, J. A. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0324-5.00036-5 · Cited by 4
Hormonal and Metabolic Effects of Short-term Energy Imbalance in Obese-Prone as Compared to Obese-Resistant Individuals
Thomas, E. A. (2014) · Cited by 4
Surgical Treatment of Morbid Obesity
Lee, C. M., & Kim, J.-H. (2017) · The Korean Journal of Helicobacter and Upper Gastrointestinal Research · doi:10.7704/kjhugr.2017.17.2.72 · Cited by 4
“(incretin)으로 생각되어 이에 대한 연구가 활발히 진행되어 오 고 있다.(55,56) 이와 같이, 장 호르몬이 혈당조절에 관여한다는 것”
A Gut Check Explains Improved Glucose Metabolism after Surgery
Laferrère, B., & Pattou, F. N. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.002 · Cited by 4
Management und Therapie
Hauner, H., Wirth, A. G., Gola, U., Teufel, M., Zipfel, S., de Zwaan, M., Hüttl, T. P., Kramer, K. M., & Winckler, K. (2013) · Springer eBooks · doi:10.1007/978-3-642-22855-1_7 · Cited by 4
One anastomosis mini-gastric bypass decreases desacyl ghrelin and improves metabolic profile in male rats with diet-induced obesity
Tuero, C., Rodrı́guez, A., Ramírez, B., Catalán, V., Cienfuegos, J. A., Gómez‐Ambrosi, J., Valentí, V., Moncada, R., Frühbeck, G., & Becerril, S. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110124 · Cited by 3

Authors: Laferrère, B., Teixeira, J., McGinty, J., Tran, H., Egger, J. R., Colarusso, A., Kovack, B., Bawa, B., Koshy, N., Lee, H., Yapp, K., & Olivan, B.
Affiliations: Obesity Research Center (B.L., H.T., J.R.E., A.C., B.K., B.B., K.Y., B.O.), St. Luke’s/Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025
Bariatric Division (J.T., J.M., N.K., H.L.), St. Luke’s/Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025
St. Luke's-Roosevelt Hospital Center (US)
ORCID: Egger, Joseph R.
Lee, Hongchan
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-07-01
Volume: 93
Issue: 7
Pages: 2479-2485
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2007-2851
PMC: PMC2453054
OpenAlex: W2146737709
Cited by: 682
References: 57
Citations by year: 2026: 9 · 2025: 10 · 2024: 11 · 2023: 18 · 2022: 17 · 2021: 25 · 2020: 25 · 2019: 39 · 2018: 21 · 2017: 45 · 2016: 48 · 2015: 44 · 2014: 57 · 2013: 72 · 2012: 59
FWCI: 63.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 67561, DK63068-05, DK 26687, R01DK067561, P30DK026687)
National Center for Research Resources (UL1RR024156)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: gastric bypass, type 2 diabetes, weight loss, incretin effect, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, proinsulin, glucagon, insulin, postprandial blood glucose, hypocaloric diet, obesity, women
MeSH terms: Adult, Blood Glucose, Diabetes Mellitus, Type 2, Diet, Reducing, Female, Gastric Inhibitory Polypeptide, Glucagon, Humans, Male, Middle Aged, Obesity, Gastric Bypass, Weight Loss, Glucagon-Like Peptide 1, Incretins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of Weight Loss by Gastric Bypass Surgery Versus Hypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks