Cited by 682Bariatric Surgery and OutcomesDiabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

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Effect of Weight Loss by Gastric Bypass Surgery Versus Hypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

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Laferrère, Blandine, Teixeira, Julio, McGinty, James, Tran, Hao, Egger, Joseph R., Colarusso, Antonia, Kovack, Betty, Bawa, Baani, Koshy, Ninan, Lee, Hongchan, Yapp, Kimberly, Olivan, Blanca·2008·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2007-2851PMC PMC2453054

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Abstract

CONTEXT: Gastric bypass surgery (GBP) results in rapid weight loss, improvement of type 2 diabetes (T2DM), and increase in incretins levels. Diet-induced weight loss also improves T2DM and may increase incretin levels. OBJECTIVE: Our objective was to determine whether the magnitude of the change of the incretin levels and effect is greater after GBP compared with a low caloric diet, after equivalent weight loss. DESIGN AND METHODS: Obese women with T2DM studied before and 1 month after GBP (n = 9), or after a diet-induced equivalent weight loss (n = 10), were included in the study. Patients from both groups were matched for age, body weight, body mass index, diabetes duration and control, and amount of weight loss. SETTING: This outpatient study was conducted at the General Clinical Research Center. MAIN OUTCOME MEASURES: Glucose, insulin, proinsulin, glucagon, gastric inhibitory peptide (GIP), and glucagon-like peptide (GLP)-1 levels were measured after 50-g oral glucose. The incretin effect was measured as the difference in insulin levels in response to oral and to an isoglycemic iv glucose load. RESULTS: At baseline, none of the outcome variables (fasting and stimulated values) were different between the GBP and diet groups. Total GLP-1 levels after oral glucose markedly increased six times (peak:17 +/- 6 to 112 +/- 54 pmol/liter; P < 0.001), and the incretin effect increased five times (9.4 +/- 27.5 to 44.8 +/- 12.7%; P < 0.001) after GBP, but not after diet. Postprandial glucose levels (P = 0.001) decreased more after GBP. CONCLUSIONS: These data suggest that early after GBP, the greater GLP-1 and GIP release and improvement of incretin effect are related not to weight loss but rather to the surgical procedure. This could be responsible for better diabetes outcome after GBP.

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Laferrère, 2007, The increase in GLP-1 levels and incretin effect after Roux-en-Y gastric bypass surgery (RYGBP) persists up to 1 year in patients with type 2 diabetes mellitus (T2DM), Obesity, 15, 7

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Items 301–400 of 678

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Wolff, B. S., Meirelles, K., Meng, Q., Pan, M., & Cooney, R. N. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00104.2009 · Cited by 24
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Background
Influence of dietary protein and its amino acid composition on postoperative outcomes after gastric bypass surgery: a systematic review
van den Broek, M., de Heide, L. J. M., Veeger, N. J. G. M., van der Wal-Oost, A. M., & van Beek, A. P. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw042 · Cited by 24
A case report
Chiappetta, S., & Stier, C. K. (2017) · Medicine · doi:10.1097/md.0000000000006348 · Cited by 25
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“[82] report transient increase in GIP levels after GBP.”
Background
Bariatric surgery in patients with late-stage type 2 diabetes: expected beneficial effects on risk ratio and outcomes
Renard, É. (2009) · Diabetes & Metabolism · doi:10.1016/s1262-3636(09)73467-6 · Cited by 22
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Can Helicobacter pylori Eradication Treatment Modify the Metabolic Response to Bariatric Surgery?
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“meal response from the entero-endocrine L cells leading to a rapid rise in meal stimulated glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and oxyntomodulin [35] which improves glucose metabolism.”
Background
The Effect of Gastrointestinal Surgery on Insulin Resistance and Insulin Secretion
Castagneto, M., & Mingrone, G. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0284-6 · Cited by 21
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Multicenter results of long-limb bypass reconstruction after gastrectomy in patients with gastric cancer and type II diabetes
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“This procedure involves altered glucose metabolism owing to different gut hormones, such as incretins, especially glucagon-like peptide-1.(19,21,22) Recently, the incidence of early gastric cancer has increased in Korea,(23) so there is increased possibility that patients with gastric cancer and type II DM will achiev…”
Background
Perioperative Glycemic Management of Patients Undergoing Bariatric Surgery
Rometo, D. A., & Korytkowski, M. T. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0718-6 · Cited by 21
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“Studies in rodents [3,4] and humans [5–7] show that the antidiabetic effect of gastric bypass surgery results from weight loss–independent”
Background
Physiological and molecular responses to bariatric surgery: markers or mechanisms underlying T2DM resolution?
Hutch, C. R., & Sandoval, D. A. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13194 · Cited by 21
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“This was observed when they compared weight loss by bariatric surgery to weight loss achieved with clinical treatments or purely restrictive treatments such as gastric banding, which have little or no effect on the post-prandial hormonal profile (30-32).”
Contribution of endogenous glucagon-like peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks after Roux-en-Y gastric bypass (RYGB)
Shah, M., LAURENTI, M. C., Man, C. D., Ma, J., Cobelli, C., Rizza, R. A., & Vella, A. V. (2018) · Metabolism · doi:10.1016/j.metabol.2018.12.005 · Cited by 20
“An improvement in β-cell function [7] occurs notwithstanding postprandial GLP-1 concentrations far lower than those observed after RYGB [10].”
Background
Beta-cell sensitivity to insulinotropic gut hormones is reduced after gastric bypass surgery
Salehi, M., Gastaldelli, A., & D’Alessio, D. A. (2019) · Gut · doi:10.1136/gutjnl-2018-317760 · Cited by 18
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“For example, the rise in peak glucagon-like peptide (GLP-1) concentration following a mixed meal or oral glucose can be five- to tenfold higher after RYGB compared with weight-matched nonsurgical controls [6, 22 ].”
Background
EFFECTS OF LONG-TERM ROUX-EN-Y GASTRIC BYPASS ON BODY WEIGHT AND CLINICAL METABOLIC COMORBIDITIES IN BARIATRIC SURGERY SERVICE OF A UNIVERSITY HOSPITAL
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Kashyap, S. R., & Schauer, P. R. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01577.x · Cited by 19
“In most cases, a dramatic lowering in glucose levels has been observed days to weeks following surgery, before major weight loss but in the setting of enforced caloric restriction [14,18].”
Background
Role of the Gut in the Temporal Changes of β-Cell Function After Gastric Bypass in Individuals With and Without Diabetes Remission
PRASAD, M. A., Mark, V., Ligon, C., Dutia, R., Nair, N., Shah, A. M., & Laferrère, B. (2021) · Diabetes Care · doi:10.2337/dc21-1270 · Cited by 19
Laparoscopic sleeve gastrectomy for morbid obesity improves gut microbiota balance, increases colonic mucosal-associated invariant T cells and decreases circulating regulatory T cells
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“Various mechanisms have been reported to improve metabolism after metabolic surgery, including the involvement of gastrointestinal hormones (incretin [3], ghrelin [4], and others), bile acid signaling [5, 6], and adipokines produced by adipocytes (adiponectin, leptin, TNF-α, and others) [7].”
Background
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“…after oral glucose increased 6 times, and the incretin effect increased 5 times after RYGB, but not after diet, suggesting that after RYGB, the greater GLP1 release and improvement of incretin effect are not related to weight loss but rather to the surgical procedure (Laferr ere et al. 2008).”
Background
Gut feelings about diabetes
Laferrère, B. (2012) · Endocrinología y Nutrición · doi:10.1016/j.endonu.2012.01.010 · Cited by 18
THE ROLE OF METABOLIC SURGERY FOR PATIENTS WITH OBESITY GRADE I AND TYPE 2 DIABETES NOT CONTROLLED CLINICALLY
Campos, J. M., RAMOS, A. C., SZEGO, T., Zilberstein, B., Neto, H. F. E. C., & COHEN, R. V. (2016) · ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) · doi:10.1590/0102-6720201600s10025 · Cited by 21
Changes in glycemia, insulin and gut hormone responses to a slowly ingested solid low-carbohydrate mixed meal after laparoscopic gastric bypass or band surgery
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Roux‐en‐Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission
Pop, L. M., Mari, A., Zhao, T., Mitchell, L., Burgess, S. C., Li, X., ADAMS-HUET, B. A., & Lingvay, I. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13287 · Cited by 19
“First, these studies employed different degrees of caloric restriction, ranging from <300 kcal/d(14) to as much as 1000 kcal/d.(16,17) All studies that noted a differential effect of RYGB vs diet employed a higher caloric intake (800–1000 kcal/d) in the diet groups, leading to a slower weight loss rate, which could ex…”
BackgroundResult
Short-term effects of Vertical sleeve gastrectomy and Roux-en-Y gastric bypass on glucose homeostasis
Gudbrandsen, O. A., Dankel, S. N., Skumsnes, L., Flølo, T. N., Folkestad, O. H., Nielsen, H. J., Våge, V., Mohn, A. C., Nedrebø, B. G., Sagen, J. V., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51347-x · Cited by 18
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Evaluation of the Influence of Whole and Defatted Flaxseed on Satiety, Glucose, and Leptin Levels of Women in the Late Postoperative Stage of Bariatric Surgery
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“A liquid meal, for example, in spite of rapid emptying, can be completely absorbed in the duodenum and not reach the bottom of the ileum in healthy subjects; consequently, it does not stimulate the L cells (located in the distal intestine and activated in response to the presence of carbohydrates and fat) [42, 44], th…”
Background
Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes
Liu, T., Zou, X., Ruze, R., & Xu, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1031610 · Cited by 22
“The impaired GLP-1 and GIP secretion and function in obese patients were partially restored after gastric bypass surgery or VSG, compared to those who received a low-calorie diet with equivalent weight loss (75, 88, 89).”
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“2. Glucose control improves more after gastric bypass than with equivalent weight loss obtained by dietary intervention [ 12 ] or pure restrictive bariatric procedures [13, 14].”
Background
Outcomes in weight loss, fasting blood glucose and glycosylated hemoglobin in a sample of 415 obese patients, included in the database of the European accreditation council for excellence centers for bariatric surgery with laparoscopic one anastomosis gastric bypass.
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Halperin, F., & Goldfine, A. B. (2013) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32835edbb0 · Cited by 19
“GLP-1 concentrations increase by a factor of 5–10 in response to nutrient challenges following RYGB [38,39,40] but are not seen after diet-induced weight loss [32].”
BackgroundInfluential
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Malin, S. K., & Kashyap, S. R. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.02.035 · Cited by 18
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BackgroundInfluential
Endokrynne implikacje otyłości i zabiegów bariatrycznych
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Mechanisms of surgical control of type 2 diabetes: GLP-1 is the key factor—Maybe
Salehi, M., & D’Alessio, D. A. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.05.008 · Cited by 17
“glucose [29, 30, 34] and a larger incretin effect [13, 14, 32] appear to account for enhanced mealinduced insulin secretion after RYGB, while the role of the incretin effect after SG is yet to be defined.”
Background
Effect of sitagliptin on glucose control in type 2 diabetes mellitus after Roux‐en‐Y gastric bypass surgery
Shah, A. M., Levesque, K., Pierini, E., Rojas, B., Ahlers, M. J., Stano, S., Holter, M. M., Dutia, R., Belsley, S., McGinty, J., et al. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13139 · Cited by 17
Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control
Fernandez-Cachon, M. L., Pedersen, S. L., Rigbolt, K. T. G., Zhang, C., Fabricius, K., Hansen, H. H., Elster, L., Fink, L. N., Schäfer, M., Rhee, N. A., et al. (2017) · Peptides · doi:10.1016/j.peptides.2017.12.024 · Cited by 17
An investigation of the neural mechanisms underlying the efficacy of the adjustable gastric band
Stefanidis, A., Forrest, N., Brown, W. A., Dixon, J. B., O’Brien, P. B., Kampe, J., & Oldfield, B. J. (2015) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2015.11.020 · Cited by 17
The difference of glucostatic parameters according to the remission of diabetes after Roux‐en‐Y gastric bypass
Kim, M. K., Lee, H. H., Lee, S., Kwon, H., Baek, K., Kim, E. K., Lee, K. W., & Song, K. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2297 · Cited by 17
Metabolic surgery: gastric bypass for the treatment of type 2 diabetes mellitus
Quevedo, M. D. P., Palermo, M., Serra, E. E., & Ackermann, M. A. (2017) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2017.05.10 · Cited by 18
Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism
West, J. A., Ghosh, S. S., Parkes, D. G., Tsakmaki, A., Grønlund, R. V., Pedersen, P. J., MAGGS, D. G., Rajagopalan, H., & Bewick, G. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0249239 · Cited by 19
“However, contradictory reports regarding GIP secretion following RYGB exist; some report a reduction in GIP [19, 20], others no alteration [21] whilst others an increase in secretion [22].”
BackgroundInfluential
Reduction of Plasma BCAAs following Roux-en-Y Gastric Bypass Surgery Is Primarily Mediated by FGF21
Shah, H., Kramer, A., Mullins, C. A., Mattern, M., Gannaban, R. B., Townsend, R. L., Campagna, S. R., Morrison, C. D., Berthoud, H., & Shin, A. C. (2023) · Nutrients · doi:10.3390/nu15071713 · Cited by 17
“In addition to inducing a significant loss of excess body weight and fat mass, RYGB has shown to be very effective in both short- and long-term improvement in glycemic control and insulin sensitivity, often better than those achieved by conventional medical therapy with or without lifestyle interventions [9,10].”
Background
Tissue-Specific Effects of Bariatric Surgery Including Mitochondrial Function
Dankel, S. N., Staalesen, V., Bjørndal, B., Berge, R. K., Mellgren, G., & Burri, L. (2011) · Journal of Obesity · doi:10.1155/2011/435245 · Cited by 16
“Importantly, a stimulatory effect on the circulating levels of incretins such as GLP-1 and glucose-dependent insulinotropic polypeptide (GIP), which augment insulin secretion, was not observed with energy restriction in diabetic patients [23].”
Background
Metabolic Surgery for Type 2 Diabetes in Patients with a BMI of <35 kg/m2: A Surgeon’s Perspective
COHEN, R. V., Caravatto, P. P. D. P., & Petry, T. B. Z. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0930-2 · Cited by 16
“Earlier improvement in glycemia occurred in patients submitted to Roux-en-Y gastric bypass (RYGB) compared with laparoscopic adjustable gastric banding (LAGB) with the same amount of weight loss [28, 29].”
Background
Surgical Treatments for Obesity
Vetter, M. L., Dumon, K. R., & Williams, N. N. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.08.012 · Cited by 16
Gastric bypass surgery in non-obese patients with type 2 diabetes mellitus: a 1-year follow-up of 58 cases in Chinese.
Cui, J.-F., Chen, T., Shi, L., Yan, H.-T., & Tang, L. (2015) · Europe PMC (PubMed Central) · Cited by 16
Changes in GIP gene expression following bariatric surgery
Moran-Atkin, E., Brody, F. J., Fu, S. W., & Rojkind, M. (2013) · Surgical Endoscopy · doi:10.1007/s00464-012-2764-8 · Cited by 18
Effect of bariatric surgery combined with medical therapy versus intensive medical therapy or calorie restriction and weight loss on glycemic control in Zucker diabetic fatty rats
Abegg, K., Corteville, C., Docherty, N. G., Boza, C., Lutz, T. A., Muñoz, R., & le Roux, C. W. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00331.2014 · Cited by 16
Duodenal Electric Stimulation
Aberle, J., Busch, P., Veigel, J., Duprée, A., Röesch, T., zu Eulenburg, C., Paschen, B., Scholz, B.-M., Wolter, S., Sauer, N., et al. (2015) · Obesity Surgery · doi:10.1007/s11695-015-1774-8 · Cited by 16
“Both lead to an improvement of blood glucose levels [4, 5].”
Background
The Effects of One-Anastomosis Gastric Bypass on Glucose Metabolism in Goto-Kakizaki Rats
Zubiaga, L., Abad, R., Ruíz-Tóvar, J., Enriquez, P., Vilchez, J. A., Calzada, M., Gracia, J. A. P. D., & Deitel, M. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2138-8 · Cited by 16
Metabolic surgery and intestinal gene expression: Digestive tract and diabetes evolution considerations
Rodrigues, M. R. D. S., Santo, M. A., Fávero, G. M., Vieira, E. C., Artoni, R. F., Nogaroto, V., de Moura, E. G., Lisboa, P. C., & Milléo, F. Q. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i22.6990 · Cited by 16
Early 24-hour blood pressure response to Roux-en-Y gastric bypass in obese patients
Pedersen, J. S., Borup, C., Damgaard, M., Yatawara, V. D., Floyd, A. K., Gadsbøll, N., & Bonfils, P. K. (2016) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2016.1258725 · Cited by 16
The role of glucagon in weight loss‐mediated metabolic improvement: a systematic review and meta‐analysis
Silvestre, M. P., Goode, J. P., Vlaskovsky, P., McMahon, C., Tay, A., & Poppitt, S. D. (2017) · Obesity Reviews · doi:10.1111/obr.12631 · Cited by 17
“(34) Three of the four studies that compared diet with bariatric surgery used a commercially available low energy diet (LED) with an energy content of 3.3 to 4.4 MJ/d,(28,30,32) while the fourth study used regular food items, with an energy content (4.6 MJ) comparable to the studies where a commercial LED was used.”
BackgroundInfluential
A Murine Model of Vertical Sleeve Gastrectomy
Garibay, D., & Cummings, B. P. (2017) · Journal of Visualized Experiments · doi:10.3791/56534 · Cited by 16
Bariatric surgery and the gut-brain communication—The state of the art three years later
Diniz, M. D. F. H. S., Passos, V. M. D. A., & Diniz, M. T. C. (2010) · Nutrition · doi:10.1016/j.nut.2009.11.018 · Cited by 16
“Laferrère [51] 9 RYGBP (with DM) 10 on diet (with DM) L Before, 1 mo after [GIP pm NS [ GLP1 pm RYGBP Liou [14] 40 RYGBP 40 RYGBP distal L Before, 3, 6, and 12 mo after Ghrelin f z”
Method
Acylation stimulating protein reduction precedes insulin sensitization after BPD-DS bariatric surgery in severely obese women
Munkonda, M. N., Martin, J., Poirier, P., Carrington, A., Biron, S., Lebel, S., & Cianflone, K. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.13 · Cited by 15
Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet
Sakai, T., Kusakabe, T., Ebihara, K., Aotani, D., Yamamoto‐Kataoka, S., Zhao, M., Gumbilai, V., Ebihara, C., Aizawa‐Abe, M., Yamamoto, Y., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00272.2014 · Cited by 15
“4 pM (Table 2), which was comparable to the plasma GLP-1 level reported in obese patients after undergoing bariatric surgery, and could markedly improve glucose and energy metabolism (8, 21).”
Result
Glucagon secretion after metabolic surgery in diabetic rodents
Eickhoff, H., Louro, T. M., Matafome, P. N., Seiça, R. M. F., & Sousa, F. C. E. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0445 · Cited by 15
Non-insulin determinant pathways maintain glucose homeostasis upon metabolic surgery
Lu, Z., Wei, X., Sun, F., Zhang, H., Gao, P., Pu, Y., Wang, A., Chen, J., Tong, W., Li, Q., et al. (2018) · Cell Discovery · doi:10.1038/s41421-018-0062-x · Cited by 15
Does Weight Loss Improve Clinical Outcomes in Overweight and Obese Patients with Heart Failure?
Tabucanon, T., Wilcox, J. D., & Tang, W. H. W. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01367-z · Cited by 16
Roux-en-Y gastric bypass restores islet function and morphology independent of body weight in ZDF rats
Mosinski, J. D., Aminian, A., Axelrod, C. L., Batayyah, E., Romero‐Talamás, H., Daigle, C. R., Mulya, A., Scelsi, A. R., Schauer, P. R., Brethauer, S. A., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00467.2020 · Cited by 15
Characterization of one anastomosis gastric bypass and impact of biliary and common limbs on bile acid and postprandial glucose metabolism in a minipig model
Marciniak, C., Chávez‐Talavera, O., Caiazzo, R. J., Hübert, T., Zubiaga, L., Baud, G., Quenon, A., Descat, A., Vallez, E., Goossens, J. F., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00356.2020 · Cited by 15
Adolescent obesity and bariatric surgery
Levitsky, L. L., Misra, M., Boepple, P. A., & Hoppin, A. G. (2009) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32832101ff · Cited by 15
Early insulin sensitivity after restrictive bariatric surgery, inconsistency between HOMA-IR and steady-state plasma glucose levels
van Dielen, F. M. H., Nijhuis, J., Rensen, S. S., Schaper, N. C., Wiebolt, J., Koks, A., Prakken, F. J., Buurman, W. A., & Greve, J. W. M. (2009) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2009.11.011 · Cited by 15
“This has been illustrated by Laferrere et al. [27], who compared the oral glucose tolerance after gastric bypass surgery to the glucose tolerance after a 1 month of a very low calorie diet.”
Bariatric surgery: results in obesity and effects on metabolic parameters
Clifton, P. M. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328340b8fd · Cited by 15
How to Choose the Best Metabolic Procedure?
Castagneto‐Gissey, L., Mariolo, J. R. C., & Mingrone, G. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0590-5 · Cited by 15
Cardiac remodeling in obesity and after bariatric and metabolic surgery; is there a role for gastro-intestinal hormones?
Sanches, E. E., Timmermans, M., Topal, B., Çelik, A., Sundbom, M., Ribeiro, R. J. D. S., Parmar, C. D., Ugale, S. M., Proczko, M., Stepaniak, P. S., et al. (2019) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2019.1690991 · Cited by 15
“When the DPP-4 gene is inactivated in rodents, the plasma levels of GIP and GLP-1 will rise and there will be an increased insulin secretion after a glycemic challenge [156,158,161].”
BackgroundInfluential
Endocrine Function after Bariatric Surgery
Kim, K., & Sandoval, D. A. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160019 · Cited by 17
Diagnosis and Management of Post-Bariatric Hypoglycemia
Lawler, H. M., McGinnis, T., & Patti, M. (2025) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.2024.240335r1 · Cited by 13
Weight loss as a cure for Type 2 diabetes: fact or fantasy?
Kashyap, S. R., Louis, E. S., & Kirwan, J. P. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.11.42 · Cited by 14
Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels
Lindqvist, A., Ekelund, M., Pierzynowski, S. G., Groop, L., Hedenbro, J., & Wierup, N. (2017) · Peptides · doi:10.1016/j.peptides.2017.02.009 · Cited by 14
Obesity
Klein, S., & Romijn, J. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-29738-7.00036-8 · Cited by 14
Gut Mucosal Gene Expression and Metabolic Changes After Roux‐en‐Y Gastric Bypass Surgery
Jorsal, T., Christensen, M. M., Mortensen, B., Nygaard, E. B., Zhang, C., Rigbolt, K. T. G., Wandall, E., Langholz, E., Friis, S., Worm, D., et al. (2020) · Obesity · doi:10.1002/oby.22973 · Cited by 14
“, GLP-1(7-36)NH2 and GLP-1(7-37), and PYY concentrations were measured as previously described (15).”
BackgroundMethod
Gastric bypass and glucose metabolism
Caiazzo, R. J., Zerrweck, C., Verhaeghe, R., Hübert, T., Arnalsteen, L., & Pattou, F. N. (2009) · Diabetes & Metabolism · doi:10.1016/s1262-3636(09)73461-5 · Cited by 14
“It presents early after the operation [19], and is independent of weight loss [20].”
Satiety and gastrointestinal hormones during a Mixed Meal Tolerance Test after gastric bypass surgery: association with plasma amino acid concentrations
van den Broek, M., de Heide, L. J. M., Emous, M., Wijma, R. B., Veeger, N. J. G. M., Wolthuis, A. M., Laskewitz, A. J., Heiner-Fokkema, M. R., Kobold, A. C. M., Wolffenbuttel, B. H. R., et al. (2018) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2018.05.010 · Cited by 15
Metabolic surgery for the treatment of type 2 diabetes in patients with BMI lower than 35 kg/m2: Why caution is still needed
Halpern, B., & Mancini, M. C. (2019) · Obesity Reviews · doi:10.1111/obr.12837 · Cited by 14
“found improved glucose levels at 120 minutes and glucose area under the curve (AUC) after a 50‐g oral glucose test after RYGB but no difference between the groups in regards to fasting glucose.(73) However, the low‐caloric diet group in the study received a 1000 kcal/day diet, which was probably more than the amount i…”
Gastric Bypass Promotes More Lipid Mobilization Than a Similar Weight Loss Induced by Low-Calorie Diet
Kullberg, J., Sundbom, M., Haenni, A., Fredén, S., Johansson, L., Börnert, P., Ahlström, A., Ahlström, H. K., & Karlsson, A. (2010) · Journal of Obesity · doi:10.1155/2011/959601 · Cited by 14
Clues from Bariatric Surgery: Reversing Insulin Resistance to Heal the Heart
Khalaf, K. I., & Taegtmeyer, H. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0364-1 · Cited by 13
The effect of duodenojejunal bypass for type 2 diabetes mellitus patients below body mass index 25 kg/m2: one year follow-up
Heo, Y., Ahn, J., Shin, S. H., & Lee, Y. (2013) · Journal of the Korean Surgical Society · doi:10.4174/jkss.2013.85.3.109 · Cited by 13
“Furthermore, experimental studies in rodents [3] and humans [4-7] suggest that certain bariatric procedures may improve diabetes control.”
Background
Nutritional Support of the Obese and Critically Ill Obese Patient
Kaafarani, H. M. A., & Shikora, S. A. (2011) · Surgical Clinics of North America · doi:10.1016/j.suc.2011.04.009 · Cited by 13
Control of type 2 diabetes after 1 year of laparoscopic adjustable gastric banding in the helping evaluate reduction in obesity (HERO) study
Edelman, S. V., Ng‐Mak, D., Fusco, M., Ashton, D. W., Okerson, T. E., Liu, Q., Jin, J., & Dixon, J. B. (2014) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12313 · Cited by 13
“There is a clear incretin response to RYGB, which is absent following LAGB surgery [26,27].”
Background
Role of Metabolic Surgery in Less Obese or Non-Obese Subjects with Type 2 Diabetes: Influence Over Cardiovascular Events
COHEN, R. V., Caravatto, P. P. D. P., Petry, T. B. Z., & Cummings, D. (2013) · Current Atherosclerosis Reports · doi:10.1007/s11883-013-0355-3 · Cited by 13
Time to Glycemic Control - an Observational Study of 3 Different Operations
Çelik, A., Pouwels, S., Karaca, F. C., Çağıltay, E., Ugale, S. M., Etikán, Í., Büyükbozkırlı, D., & Kılıç, Y. E. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2344-4 · Cited by 13
“Elevations in postprandial GLP-1 have been shown to be the triggering factors for increased insulin production within one week after surgery [30], and improved oral glucose tolerance one month after surgery [31].”
Background

Authors: Laferrère, B., Teixeira, J., McGinty, J., Tran, H., Egger, J. R., Colarusso, A., Kovack, B., Bawa, B., Koshy, N., Lee, H., Yapp, K., & Olivan, B.
Affiliations: Obesity Research Center (B.L., H.T., J.R.E., A.C., B.K., B.B., K.Y., B.O.), St. Luke’s/Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025
Bariatric Division (J.T., J.M., N.K., H.L.), St. Luke’s/Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons, New York, New York 10025
St. Luke's-Roosevelt Hospital Center (US)
ORCID: Egger, Joseph R.
Lee, Hongchan
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2008-07-01
Volume: 93
Issue: 7
Pages: 2479-2485
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2007-2851
PMC: PMC2453054
OpenAlex: W2146737709
Cited by: 682
References: 57
Citations by year: 2026: 9 · 2025: 10 · 2024: 11 · 2023: 18 · 2022: 17 · 2021: 25 · 2020: 25 · 2019: 39 · 2018: 21 · 2017: 45 · 2016: 48 · 2015: 44 · 2014: 57 · 2013: 72 · 2012: 59
FWCI: 63.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 67561, DK63068-05, DK 26687, R01DK067561, P30DK026687)
National Center for Research Resources (UL1RR024156)
Topics: Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: gastric bypass, type 2 diabetes, weight loss, incretin effect, glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, proinsulin, glucagon, insulin, postprandial blood glucose, hypocaloric diet, obesity, women
MeSH terms: Adult, Blood Glucose, Diabetes Mellitus, Type 2, Diet, Reducing, Female, Gastric Inhibitory Polypeptide, Glucagon, Humans, Male, Middle Aged, Obesity, Gastric Bypass, Weight Loss, Glucagon-Like Peptide 1, Incretins

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Effect of Weight Loss by Gastric Bypass Surgery Versus Hypocaloric Diet on Glucose and Incretin Levels in Patients with Type 2 Diabetes

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