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Cited by 135Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsBone health and osteoporosis research

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Estradiol Rates of Change in Relation to the Final Menstrual Period in a Population-Based Cohort of Women

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Sowers, MaryFran R., Zheng, Huiyong, McConnell, Daniel, Nan, Bin, Harlow, Siobán D., Randolph, John F.·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-1056PMC PMC2579642
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Abstract

CONTEXT/OBJECTIVE: The aim was to characterize rates of change in serum estradiol (E2) levels across the menopausal transition and into early postmenopause. SETTING/PARTICIPANTS: We studied the Michigan Bone Health and Metabolism Study cohort of 629 women with median age of 38 yr (interquartile range, 7) at the 1992-1993 baseline with annual assessment of E2 levels over the subsequent 15-yr period. DESIGN/MAIN OUTCOME MEASURES: The purpose was to describe patterns of acceleration/deceleration in (log)E2 rates of change before and after the final menstrual period (FMP) using nonparametric and piecewise regression modeling. RESULTS: Between -10 to -2 yr to the FMP, mean fitted serum E2 population values were relatively stable. The 95% confidence bands around the slight increase in E2 rate of change 5 yr prior to the FMP included the value of no change. The fitted population mean E2 value declined 67% from 64.5 pg/ml (se = 3.6) to 21 pg/ml (se = 1.2) in the 4 yr between -2 < FMP < +2. A second significant mean E2 rate of change was identified from 6-8 yr after FMP. Fitted population mean E2 values declined 18% from 18.1 pg/ml (se = 1.3) at FMP = 6 to 14.8 pg/ml (se = 1.3) at FMP = 8. In nonobese women, the mean E2 percent decline was 42% from FMP = 6 to FMP = 8, whereas in obese women, the mean E2 percent decline over this time was 31%. CONCLUSIONS: Population mean serum E2 levels were sustained until approximately 2 yr prior to the FMP. In the ensuing 4-yr period, E2 levels declined 67%. A secondary E2 decline, commencing about 6 yr after the FMP, was observed in nonobese but not obese women.

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Crossref · 10.1210/jc.2008-1056

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  1. Guidelines for ATC classification, 2007, World Health Organization Collaborating Centre for Drug Statistics Methodology

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Metadata

Authors
Sowers, M. R., Zheng, H., McConnell, D., Nan, B., Harlow, S. D., & Randolph, J. F.
Affiliations
  • University of Michigan (US)
  • Departments of Epidemiology (M.R.S., H.Z., D.M., S.D.H.), School of Public Health, University of Michigan, Ann Arbor, Michigan 48109
  • Michigan Medicine (US)
Corresponding author
Sowers, MaryFran R.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-10-01
Volume
93
Issue
10
Pages
3847-3852
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-1056
PMC
PMC2579642
OpenAlex
W2166780509
Cited by
135
References
45
Citations by year
2026: 11 · 2025: 10 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 13 · 2019: 8 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 8 · 2012: 14
FWCI
5.81
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Michigan (48109)
  • School of Public Health, University of Michigan
  • National Institutes of Health (5r01ar040888-02, AR20557)
  • College of Pharmacy, University of Michigan
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 040888, R01AR051384, P60AR020557, AR20 557, AR051384)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD041028)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
serum estradiol, perimenopause, final menstrual period, postmenopause, estradiol decline, obesity, rate of change, women's health
MeSH terms
Adult, Estradiol, Female, Follow-Up Studies, Humans, Menopause, Menstruation, Cohort Studies, Body Mass Index, Postmenopause

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