CoChat
Sign Up
Cited by 135Menopause: Health Impacts and TreatmentsEstrogen and related hormone effectsBone health and osteoporosis research

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Estradiol Rates of Change in Relation to the Final Menstrual Period in a Population-Based Cohort of Women

Open access
Sowers, MaryFran R., Zheng, Huiyong, McConnell, Daniel, Nan, Bin, Harlow, Siobán D., Randolph, John F.·2008·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-1056PMC PMC2579642
Open this paper in CoChat — free accountOpen PDF

Abstract

CONTEXT/OBJECTIVE: The aim was to characterize rates of change in serum estradiol (E2) levels across the menopausal transition and into early postmenopause. SETTING/PARTICIPANTS: We studied the Michigan Bone Health and Metabolism Study cohort of 629 women with median age of 38 yr (interquartile range, 7) at the 1992-1993 baseline with annual assessment of E2 levels over the subsequent 15-yr period. DESIGN/MAIN OUTCOME MEASURES: The purpose was to describe patterns of acceleration/deceleration in (log)E2 rates of change before and after the final menstrual period (FMP) using nonparametric and piecewise regression modeling. RESULTS: Between -10 to -2 yr to the FMP, mean fitted serum E2 population values were relatively stable. The 95% confidence bands around the slight increase in E2 rate of change 5 yr prior to the FMP included the value of no change. The fitted population mean E2 value declined 67% from 64.5 pg/ml (se = 3.6) to 21 pg/ml (se = 1.2) in the 4 yr between -2 < FMP < +2. A second significant mean E2 rate of change was identified from 6-8 yr after FMP. Fitted population mean E2 values declined 18% from 18.1 pg/ml (se = 1.3) at FMP = 6 to 14.8 pg/ml (se = 1.3) at FMP = 8. In nonobese women, the mean E2 percent decline was 42% from FMP = 6 to FMP = 8, whereas in obese women, the mean E2 percent decline over this time was 31%. CONCLUSIONS: Population mean serum E2 levels were sustained until approximately 2 yr prior to the FMP. In the ensuing 4-yr period, E2 levels declined 67%. A secondary E2 decline, commencing about 6 yr after the FMP, was observed in nonobese but not obese women.

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.2008-1056

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 1

  1. Guidelines for ATC classification, 2007, World Health Organization Collaborating Centre for Drug Statistics Methodology

Cited by

Sorted by citations

See all 135

Related

See all

Metadata

Authors
Sowers, M. R., Zheng, H., McConnell, D., Nan, B., Harlow, S. D., & Randolph, J. F.
Affiliations
  • University of Michigan (US)
  • Departments of Epidemiology (M.R.S., H.Z., D.M., S.D.H.), School of Public Health, University of Michigan, Ann Arbor, Michigan 48109
  • Michigan Medicine (US)
Corresponding author
Sowers, MaryFran R.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2008-10-01
Volume
93
Issue
10
Pages
3847-3852
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-1056
PMC
PMC2579642
OpenAlex
W2166780509
Cited by
135
References
45
Citations by year
2026: 11 · 2025: 10 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 13 · 2019: 8 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 8 · 2012: 14
FWCI
5.81
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Michigan (48109)
  • School of Public Health, University of Michigan
  • National Institutes of Health (5r01ar040888-02, AR20557)
  • College of Pharmacy, University of Michigan
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 040888, R01AR051384, P60AR020557, AR20 557, AR051384)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R24HD041028)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
serum estradiol, perimenopause, final menstrual period, postmenopause, estradiol decline, obesity, rate of change, women's health
MeSH terms
Adult, Estradiol, Female, Follow-Up Studies, Humans, Menopause, Menstruation, Cohort Studies, Body Mass Index, Postmenopause

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review