Changes in body composition and weight during the menopause transition
Open accessAbstract
BACKGROUND. The relation between the menopause transition (MT) and changes in body composition or weight remains uncertain. We hypothesized that, independent of chronological aging, the MT would have a detrimental influence on body composition. METHODS. Participants were from the longitudinal Study of Women’s Health Across the Nation (SWAN) cohort. We assessed body composition by dual energy x-ray absorptiometry. Multivariable mixed effects regressions fitted piece-wise linear models to repeated measures of outcomes as a function of time before or after the final menstrual period (FMP). Covariates were age at FMP, race, study site, and hormone therapy. RESULTS. Fat and lean mass increased prior to the MT. At the start of the MT, rate of fat gain doubled, and lean mass declined; gains and losses continued until 2 years after the FMP. After that, the trajectories of fat and lean mass decelerated to zero slope. Weight climbed linearly during premenopause without acceleration at the MT. Its trajectory became flat after the MT. CONCLUSION. Accelerated gains in fat mass and losses of lean mass are MT-related phenomena. The rate of increase in the sum of fat mass and lean mass does not differ between premenopause and the MT; thus, there is no discernable change in rate of weight gain at the start of the MT. FUNDING. NIH, Department of Health and Human Services (DHHS), through the National Institute on Aging, National Institute of Nursing Research, and NIH Office of Research on Women’s Health (U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, and U01AG012495).
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Cites
Locally Weighted Regression: An Approach to Regression Analysis by Local Fitting
Cleveland, W. S., & Devlin, S. J. (1988) · Journal of the American Statistical Association · doi:10.1080/01621459.1988.10478639 · Cited by 5,740 · see citing works
Prospective Studies Collaboration (2009) · The Lancet · doi:10.1016/s0140-6736(09)60318-4 · Cited by 4,807 · see citing works
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329 · see citing works
Increased visceral fat and decreased energy expenditure during the menopausal transition
Lovejoy, J. C., Champagne, C. M., de Jonge, L., Xie, H., & Smith, S. R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.25 · Cited by 1,020 · cited 1× · see citing works
“Small cross-sectional and longitudinal observational studies find that resting energy expenditure (REE) is less in postmenopause than in premenopause (29, 30).”
BackgroundOverweight and obesity: prevalence, consequences, and causes of a growing public health problem
Williams, E. P., Mesidor, M., Winters, K., Dubbert, P. M., & Wyatt, S. B. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0169-4 · Cited by 922 · see citing works
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men
Finkelstein, J. S., Lee, H., Burnett-Bowie, S.-A. M., Pallais, J. C., Yu, E. W., Borges, L. F., Jones, B. F., Barry, C. V., Wulczyn, K. E., Thomas, B. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1206168 · Cited by 782 · see citing works
Self-citationUnderstanding weight gain at menopause
Davis, S. R., Castelo‐Branco, C., Chedraui, P. A., Lumsden, M. A., Nappi, R. E., Shah, D., Villaseca, P., & as the Writing Group of the International Menopause Society for World Menopause Day 2012 (2012) · Climacteric · doi:10.3109/13697137.2012.707385 · Cited by 611 · see citing works
Changes in Body Composition in Women over Six Years at Midlife: Ovarian and Chronological Aging
Sowers, M., Zheng, H., Tomey, K., Karvonen-Gutierrez, C., Jannausch, M., Li, X., Yosef, M., & Symons, J. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1393 · Cited by 470 · see citing works
Self-citationBurger, H. G., Dudley, E. C., Cui, J., Dennerstein, L., & Hopper, J. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6740 · Cited by 439 · see citing works
The genetic contribution to non-syndromic human obesity
Walley, A. J., Asher, J. E., & Froguel, P. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2594 · Cited by 402 · see citing works
Weight Gain at the Time of Menopause
Wing, R. R. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400010111016 · Cited by 394 · see citing works
Randolph, J. F., Zheng, H. T., Sowers, M. R., Crandall, C. J., Crawford, S. L., Gold, E. B., & Vuga, M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1746 · Cited by 372 · see citing works
Sternfeld, B. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh299 · Cited by 360 · see citing works
Self-citationBurger, H. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2832 · Cited by 347 · see citing works
Blocking FSH induces thermogenic adipose tissue and reduces body fat
Liu, P., Ji, Y., Yuen, T., Rendina-Ruedy, E., DeMambro, V., Dhawan, S., Abu‐Amer, W., Izadmehr, S., Zhou, B., Shin, A. C., et al. (2017) · Nature · doi:10.1038/nature22342 · Cited by 343 · see citing works
Characterization of Perimenopausal Bone Loss: A Prospective Study
Recker, R. R., Lappe, J. M., Davies, K. M., & Heaney, R. P. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.10.1965 · Cited by 335 · see citing works
Greendale, G. A., Sowers, M., Han, W., Huang, M.-H., Finkelstein, J. S., Crandall, C. J., Lee, J. S., & Karlamangla, A. S. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.534 · Cited by 309 · see citing works
Self-citationMüller, M. J., Lagerpusch, M., Enderle, J., Schautz, B., Heller, M., & Bosy‐Westphal, A. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01033.x · Cited by 293 · see citing works
Turgeon, J. L., Carr, M. C., Maki, P. M., Mendelsohn, M. E., & Wise, P. M. (2006) · Endocrine Reviews · doi:10.1210/er.2005-0020 · Cited by 263 · see citing works
Abdulnour, J., Doucet, É., Brochu, M., Lavoie, J.-M., Strychar, I., Rabasa-Lhoret, R., & Prud’homme, D. (2012) · Menopause · doi:10.1097/gme.0b013e318240f6f3 · Cited by 229 · see citing works
Karvonen-Gutierrez, C. A., & Kim, C. (2016) · Healthcare · doi:10.3390/healthcare4030042 · Cited by 219 · see citing works
Self-citationJolly, C., & MAHOUDEAU, J. A. (1984) · PubMed · Cited by 191 · see citing works
Female hormones: do they influence muscle and tendon protein metabolism?
Hansen, M. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665117001951 · Cited by 172 · see citing works
Al-Safi, Z. A., & Polotsky, A. J. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2014.12.002 · Cited by 171 · see citing works
Menopause, Physical Activity, and Body Composition/Fat Distribution in Midlife Women
Sternfeld, B., Bhat, A. K., Wang, H., Sharp, T. A., & Quesenberry, C. P. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000170083.41186.b1 · Cited by 149 · see citing works
Self-citationWeight gain and the menopause: a 5-year prospective study
Guthrie, J. R., Dennerstein, L., & DUDLEY, E. C. (1999) · Climacteric · doi:10.3109/13697139909038063 · Cited by 136 · see citing works
Sowers, M. R., Zheng, H., McConnell, D., Nan, B., Harlow, S. D., & Randolph, J. F. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1056 · Cited by 135 · see citing works
Relative contribution of aging and menopause to changes in lean and fat mass in segmental regions
Douchi, T., Yamamoto, S., Yoshimitsu, N., Andoh, T., Matsuo, T., & Nagata, Y. (2002) · Maturitas · doi:10.1016/s0378-5122(02)00161-5 · Cited by 127 · see citing works
A Longitudinal Study of Weight and the Menopause Transition
Crawford, S. L., Casey, V. A., Avis, N. E., et al. (2000) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200007020-00005 · Cited by 126 · see citing works
Smith, G. I., Yoshino, J., Reeds, D. N., Bradley, D., Burrows, R. E., Heisey, H. D., Moseley, A. C., & Mittendorfer, B. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2835 · Cited by 124 · see citing works
Follicle Stimulating Hormone and Its Rate of Change in Defining Menopause Transition Stages
Sowers, M. R., Zheng, H. T., McConnell, D. S., Nan, B., Harlow, S. D., & Randolph, J. F. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0482 · Cited by 114 · see citing works
Hormonal Changes During Menopause and the Impact on Fluid Regulation
Stachenfeld, N. S. (2014) · Reproductive Sciences · doi:10.1177/1933719113518992 · Cited by 111 · see citing works
Burger, H. (1999) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(98)00145-9 · Cited by 107 · see citing works
Ho, S. C., Wu, S., Chan, S. G., & Sham, A. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.33 · Cited by 106 · see citing works
Sowers, M. R., Zheng, H. T., Jannausch, M. L., McConnell, D. S., Nan, B., Harlow, S. D., & Randolph, J. F. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0659 · Cited by 100 · see citing works
Regulation of Body Composition and Bioenergetics by Estrogens
Pelt, R. E. V., Gavin, K. M., & Kohrt, W. M. (2015) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2015.05.011 · Cited by 94 · see citing works
Razmjou, S., Abdulnour, J., Bastard, J., Fellahi, S., Doucet, É., Brochu, M., Lavoie, J.-M., RABASA-LHORET, R. P. R., & Prud’homme, D. (2017) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000951 · Cited by 67 · see citing works
Shea, K. L., Gavin, K. M., Melanson, E. L., Gibbons, E., Stavros, A., Wolfe, P., Kittelson, J. M., Vondracek, S. F., Schwartz, R. S., Wierman, M. E., et al. (2015) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000430 · Cited by 65 · see citing works
Hodson, L., Harnden, K., Banerjee, R., Real, B., Marinou, K., Karpe, F., & Fielding, B. A. (2014) · Journal of Nutritional Science · doi:10.1017/jns.2013.38 · Cited by 59 · see citing works
Regulation of energy expenditure by estradiol in premenopausal women
Melanson, E. L., Gavin, K. M., Shea, K. L., Wolfe, P., Wierman, M. E., Schwartz, R. S., & Kohrt, W. M. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00473.2015 · Cited by 58 · see citing works
Wells, J. C. K. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu060 · Cited by 57 · see citing works
Changes in body mass index around menopause: a population study of Chilean woman
mel, J. E. B., Castelo‐Branco, C., Rocangliolo, M. E., et al. (2001) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200107000-00004 · Cited by 56 · see citing works
Pöllänen, E., Ronkainen, P. H. A., Horttanainen, M., Takala, T., Puolakka, J., Suominen, H., Sipilä, S., & Kovanen, V. (2010) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2010.07.003 · Cited by 54 · see citing works
Hormones, weight change and menopause
Davies, K., Heaney, R. P., Recker, R., et al. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801593 · Cited by 52 · see citing works
Estrogen Influences on Neuromuscular Function in Postmenopausal Women
Sipilä, S., Finni, T. J., & Kovanen, V. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9924-x · Cited by 43 · see citing works
Preventing Fat Gain by Blocking Follicle-Stimulating Hormone
Kohrt, W. M., & Wierman, M. E. (2017) · New England Journal of Medicine · doi:10.1056/nejmcibr1704542 · Cited by 29 · see citing works
Adiposity and the Menopausal Transition
Wildman, R. P., & Sowers, M. R. (2011) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2011.05.003 · Cited by 28 · see citing works
Postmenopausal women with a “Normal” BMI might be overweight or even obese
Rubin, R. (2018) · JAMA · doi:10.1001/jama.2018.0423 · Cited by 25 · see citing works
Sornay‐Rendu, E., Karras-Guillibert, C., Munoz, F., Claustrat, B., & Chapurlat, R. D. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1469 · Cited by 21 · see citing works
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The 2022 hormone therapy position statement of The North American Menopause Society
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Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450 · see citing works
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Sims, S. T., Kerksick, C. M., Smith-Ryan, A. E., Janse de Jonge, X. A. K., Hirsch, K. R., Arent, S. M., Hewlings, S. J., Kleiner, S. M., Bustillo, E., Tartar, J. L., et al. (2023) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2023.2204066 · Cited by 91 · see citing works
Gould, L. M., Gordon, A. N., Cabre, H. E., Hoyle, A. T., Ryan, E. D., Hackney, A. C., & Smith-Ryan, A. E. (2022) · Menopause · doi:10.1097/gme.0000000000001932 · Cited by 45 · see citing works
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- Authors
- Greendale, G. A., Sternfeld, B., Huang, M., Han, W., Karvonen-Gutierrez, C., Ruppert, K., Cauley, J. A., Finkelstein, J. S., Jiang, S.-F., & Karlamangla, A. S.
- Affiliations
- University of California, Los Angeles (US)
- Kaiser Permanente (US)
- University of Michigan (US)
- University of Pittsburgh (US)
- Massachusetts General Hospital (US)
- ORCID
- Venue
- JCI Insight
- Published
- 2019-03-07
- Volume
- 4
- Issue
- 5
- ISSN
- 2379-3708 (ISSN-L)
- PMC
- PMC6483504
- OpenAlex
- W2921175365
- Cited by
- 491
- References
- 49
- Citations by year
- 2026: 115 · 2025: 90 · 2024: 85 · 2023: 57 · 2022: 62 · 2021: 44 · 2020: 29 · 2019: 6 · 2018: 1
- FWCI
- 28.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- JCI Insight (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH/NIA (U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- perimenopause, body composition, fat mass, lean body mass, weight gain, final menstrual period, premenopause, aging, hormone therapy, women's health
- MeSH terms
- Adult, Aging, Body Composition, Body Weight, Female, Humans, Longitudinal Studies, Menopause, Middle Aged, Obesity, United States, Weight Gain, Body Mass Index, Premenopause
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