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Cited by 276

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women

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Dillon, Edgar L., Sheffield-Moore, Melinda, Paddon-Jones, Douglas, Gilkison, Charles, Sanford, Arthur P., Casperson, Shanon L., Jiang, Jie, Chinkes, David L., Urban, Randall J.·2009·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2008-1564
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Abstract

CONTEXT: Inadequate dietary protein intake has been implicated in sarcopenia. OBJECTIVE AND DESIGN: The objectives of this study were to determine whether: 1) chronic essential amino acid (EAA) supplementation improves postabsorptive muscle protein fractional synthesis rate (FSR), lean body mass (LBM), and one-repetition maximum muscle strength, and androgen receptor and IGF-I muscle protein expression; and 2) the acute anabolic response to EAA ingestion is preserved after a 3-month supplementation period. Using a randomized, double-blinded, placebo-controlled design, older women (68 +/- 2 yr) were assigned to receive either placebo (n = 7), or 15 g EAA/d [supplemented treatment group (SUP)] (n = 7) for 3 months. Metabolic outcomes were assessed in association with stable isotope studies conducted at 0 and 3 months. SETTING: The study was performed at The University of Texas Medical Branch General Clinical Research Center. RESULTS: Ingestion of 7.5 g EAA acutely stimulated FSR in both groups at 0 months (P < 0.05). Basal FSR at 3 months was increased in SUP only. The magnitude of the acute response to EAA was unaltered after 3 months in SUP. LBM increased in SUP only (P < 0.05). One-repetition maximum strength remained unchanged in both groups. Basal IGF-I protein expression increased in SUP after 3 months (P = 0.05), with no changes in androgen receptor or total and phosphorylated Akt, mammalian target of rapamycin, S6 kinase, and 4E-binding protein. CONCLUSIONS: EAA improved LBM and basal muscle protein synthesis in older individuals. The acute anabolic response to EAA supplementation is maintained over time and can improve LBM, possibly offsetting the debilitating effects of sarcopenia.

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Research works printed but not linked: 26

  1. Bunker, 1987, Nitrogen balance studies in apparently healthy elderly people and those who are housebound., Br J Nutr, 57, 211, 10.1079/BJN19870027 · DOI
  2. Campbell, 1996, Protein requirements of elderly people, Eur J Clin Nutr, 50, S180
  3. Campbell, 2001, The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle, J Gerontol A Biol Sci Med Sci, 56, M373, 10.1093/gerona/56.6.M373 · DOI · Paper page
  4. Arnaud-Battandier, 2004, Use of oral supplements in malnourished elderly patients living in the community: a pharmaco-economic study., Clin Nutr, 23, 1096, 10.1016/j.clnu.2004.02.007 · DOI
  5. Lauque, 2000, Protein-energy oral supplementation in malnourished nursing-home residents. A controlled trial., Age Ageing, 29, 51, 10.1093/ageing/29.1.51 · DOI
  6. Fiatarone Singh, 2000, The effect of oral nutritional supplements on habitual dietary quality and quantity in frail elders., J Nutr Health Aging, 4, 5
  7. Volpi, 1999, Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction, Am J Physiol, 277, E513
  8. Katsanos, 2005, Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids., Am J Clin Nutr, 82, 1065, 10.1093/ajcn/82.5.1065 · DOI · Paper page
  9. Zhang, 1996, An isotopic method for measurement of muscle protein fractional breakdown rate in vivo, Am J Physiol, 270, E759
  10. Patterson, 1997, Use of stable isotopically labeled tracers for studies of metabolic kinetics: an overview., Metabolism, 46, 322, 10.1016/S0026-0495(97)90260-2 · DOI
  11. Wolfe, 1992, Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis
  12. Bergstrom, 1974, Intracellular free amino acid concentration in human muscle tissue., J App Physiol, 36, 693, 10.1152/jappl.1974.36.6.693 · DOI · Paper page
  13. Calder, 1992, The determination of low d5-phenylalanine enrichment (0.002–0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spectrometry., Rapid Commun Mass Spectrom, 6, 421, 10.1002/rcm.1290060704 · DOI
  14. Wolfe, 2005, Isotope tracers in metabolic research: principles and practice of kinetic analysis
  15. Jorfeldt, 1971, Leg blood flow during exercise in man., Clin Sci, 41, 459, 10.1042/cs0410459 · DOI · Paper page
  16. Katch, 1975, Predictability of body segment volumes in living subjects., Hum Biol, 47, 203
  17. Baumann, 1994, Precursor pools of protein synthesis: a stable isotope study in a swine model, Am J Physiol, 267, E203
  18. Biolo, 1997, An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein, Am J Physiol, 273, E122
  19. Paddon-Jones, 2005, Exogenous amino acids stimulate human muscle anabolism without interfering with the response to mixed meal ingestion, Am J Physiol Endocrinol Metab, 288, E761, 10.1152/ajpendo.00291.2004 · DOI · Paper page
  20. Kimball, 2006, Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis, J Nutr, 136, 227S, 10.1093/jn/136.1.227S · DOI · Paper page
  21. Dardevet, 2000, Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age., J Nutr, 130, 2630, 10.1093/jn/130.11.2630 · DOI
  22. Anthony, 2002, Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine, Am J Physiol Endocrinol Metab, 282, E1092, 10.1152/ajpendo.00208.2001 · DOI
  23. Rasmussen, 2006, Insulin resistance of muscle protein metabolism in aging., FASEB J, 20, 768, 10.1096/fj.05-4607fje · DOI · Paper page
  24. Latres, 2005, Insulin-like growth factor-1 (IGF-1) inversely regulates atrophy-induced genes via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway., J Biol Chem, 280, 2737, 10.1074/jbc.M407517200 · DOI · Paper page
  25. Stitt, 2004, The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors., Mol Cell, 14, 395, 10.1016/S1097-2765(04)00211-4 · DOI · Paper page
  26. Harber, 2005, Effects of dietary carbohydrate restriction with high protein intake on protein metabolism and the somatotropic axis., J Clin Endocrinol Metab, 90, 5175, 10.1210/jc.2005-0559 · DOI

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Metadata

Authors
Dillon, E. L., Sheffield-Moore, M., Paddon-Jones, D., Gilkison, C., Sanford, A. P., Casperson, S. L., Jiang, J., Chinkes, D. L., & Urban, R. J.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2009-05-01
Volume
94
Issue
5
Pages
1630-1637
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2008-1564
OpenAlex
W2114787201
Cited by
276
References
14
FWCI
7.01
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women. https://app.cochat.ai/papers/10.1210/jc.2008-1564
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Dillon, E. L., Sheffield-Moore, M., Paddon-Jones, D., Gilkison, C., Sanford, A. P., Casperson, S. L., Jiang, J., Chinkes, D. L., & Urban, R. J. (2009). Amino Acid Supplementation Increases Lean Body Mass, Basal Muscle Protein Synthesis, and Insulin-Like Growth Factor-I Expression in Older Women. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2008-1564

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