Effects of Exercise and Amino Acid Supplementation on Body Composition and Physical Function in Community‐Dwelling Elderly Japanese Sarcopenic Women: A Randomized Controlled Trial
Open accessAbstract
Objectives: To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass and strength in community‐dwelling elderly sarcopenic women. Design: Randomized controlled trial. Setting: Urban community in T okyo, J apan. Participants: One hundred fifty‐five women aged 75 and older were defined as sarcopenic and randomly assigned to one of four groups: exercise and amino acid supplementation (exercise + AAS ; n = 38), exercise (n = 39), amino acid supplementation ( AAS ; n = 39), or health education ( HE ; n = 39). Intervention: The exercise group attended a 60‐minute comprehensive training program twice a week, and the AAS group ingested 3 g of a leucine‐rich essential amino acid mixture twice a day for 3 months. Measurements: Body composition was determined using bioelectrical impedance analysis. Data from interviews and functional fitness parameters such as muscle strength and walking ability were collected at baseline and after the 3‐month intervention. Results: A significant group × time interaction was seen in leg muscle mass ( P = .007), usual walking speed ( P = .007), and knee extension strength ( P = .017). The within‐group analysis showed that walking speed significantly increased in all three intervention groups, leg muscle mass in the exercise + AAS and exercise groups, and knee extension strength only in the exercise + AAS group (9.3% increase, P = .01). The odds ratio for leg muscle mass and knee extension strength improvement was more than four times as great in the exercise + AAS group (odds ratio = 4.89, 95% confidence interval = 1.89–11.27) as in the HE group. Conclusion: The data suggest that exercise and AAS together may be effective in enhancing not only muscle strength, but also combined variables of muscle mass and walking speed and of muscle mass and strength in sarcopenic women.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A recent RCT in 175 community-dwelling women with sarcopenia showed that the combination of exercise twice weekly and 3 g of leucine twice daily for 3 months was superior compared with either intervention alone.
“As for the combination of protein and exercise, a recent RCT in 175 community-dwelling women with sarcopenia showed that the combination of exercise twice weekly and 3 g of leucine twice daily for 3 months was superior compared with either intervention alone.144”
From Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group (2013) · cites this paper as [144]
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580 · see citing works
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601 · see citing works
Cohen, J. (1992) · Psychological Bulletin · doi:10.1037//0033-2909.112.1.155 · Cited by 8,771 · see citing works
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004 · see citing works
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857 · see citing works
Mitsiopoulos, N., Baumgartner, R. N., Heymsfield, S. B., Lyons, W., Gallagher, D., & Ross, R. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.115 · Cited by 1,522 · see citing works
Estimation of skeletal muscle mass by bioelectrical impedance analysis
Janssen, I., Heymsfield, S. B., Baumgartner, R. N., & Ross, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.2.465 · Cited by 1,482 · see citing works
Progressive resistance strength training for improving physical function in older adults
Liu, C.-J., & Latham, N. K. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002759.pub2 · Cited by 1,258 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.5.1231 · Cited by 1,201 · see citing works
Skeletal Muscle Cutpoints Associated with Elevated Physical Disability Risk in Older Men and Women
Janssen, I. (2004) · American Journal of Epidemiology · doi:10.1093/aje/kwh058 · Cited by 1,190 · see citing works
Body Composition in Healthy Aging
BAUMGARTNER, R. N. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06498.x · Cited by 1,078 · see citing works
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923 · see citing works
Self-citationPrevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women
Iannuzzi-Sucich, M., Prestwood, K. M., & Kenny, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.12.m772 · Cited by 890 · see citing works
Volpi, E., Kobayashi, H., Sheffield-Moore, M., Mittendorfer, B., & Wolfe, R. R. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.2.250 · Cited by 846 · see citing works
Self-citationPredictors of skeletal muscle mass in elderly men and women
Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E., & Garry, P. J. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00130-4 · Cited by 809 · see citing works
Resistance exercise for muscular strength in older adults: a meta-analysis
Peterson, M. D., Rhea, M. R., Sen, A., & Gordon, P. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.03.004 · Cited by 808 · see citing works
Evans, W. J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.5 · Cited by 606 · see citing works
Rosenberg, I. H. (1989) · American Journal of Clinical Nutrition · Cited by 589 · see citing works
Wilkinson, S. B., Tarnopolsky, M. A., MacDonald, M. J., MacDonald, J. R., Armstrong, D., & Phillips, S. M. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1031 · Cited by 530 · see citing works
Katsanos, C. S., Kobayashi, H., Sheffield‐Moore, M., Aarsland, A. A., & Wolfe, R. R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.1065 · Cited by 500 · see citing works
Self-citationChien, M., Huang, T., & Wu, Y. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01854.x · Cited by 451 · see citing works
Drummond, M. J., Dreyer, H. C., Pennings, B., Fry, C. S., Dhanani, S., Dillon, E. L., Sheffield‐Moore, M., Volpi, E., & Rasmussen, B. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00021.2008 · Cited by 391 · see citing works
Interventions for sarcopenia and muscle weakness in older people
Borst, S. E. (2004) · Age and Ageing · doi:10.1093/ageing/afh201 · Cited by 349 · see citing works
Dillon, E. L., Sheffield‐Moore, M., Paddon‐Jones, D., Gilkison, C. R., Sanford, A. P., Casperson, S. L., Jiang, J., Chinkes, D. L., & Urban, R. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1564 · Cited by 276 · see citing works
Bortz, W. M. (1982) · PubMed · Cited by 269 · see citing works
Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods
Wang, Z. M., Visser, M., Ma, R., Baumgartner, R., Kotler, D. P., Gallagher, D., & Heymsfield, S. B. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.3.824 · Cited by 255 · see citing works
Knee Extension Strength Cutpoints for Maintaining Mobility
Manini, T. M., Visser, M., Won‐Park, S., Patel, K. V., Strotmeyer, E. S., Chen, H., Goodpaster, B., De Rekeneire, N., Newman, A. B., Simonsick, E. M., et al. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01087.x · Cited by 249 · see citing works
Milk ingestion stimulates net muscle protein synthesis following resistance exercise
ELLIOT, T. A., CREE, M. G., SANFORD, A. P., WOLFE, R. R., & TIPTON, K. D. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000210190.64458.25 · Cited by 237 · see citing works
Paddon-Jones, D., Sheffield-Moore, M., Katsanos, C. S., Zhang, X.-J., & Wolfe, R. R. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.006 · Cited by 223 · cited 1× · see citing works
“The previous studies have also shown that ingestion of essential amino acids can induce muscle protein anabolism in elderly adults.(10,11) One study showed that the combination of resistance exercise and essential amino acid supplementation (AAS) augmented muscle protein From the Research Team for Promoting Independen…”
BackgroundSuzuki, T., Kim, H., Yoshida, H., & Ishizaki, T. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0530-2 · Cited by 204 · see citing works
Self-citationBortz, W. M. (1982) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1982.03330100041028 · Cited by 192 · see citing works
Muscle Size Responses to Strength Training in Young and Older Men and Women
Roth, S. M., Ivey, F. M., Martel, G. F., Lemmer, J. T., HURLBUT, D. E., Siegel, E. L., Metter, E. J., Fleg, J. L., Fozard, J. L., Kostek, M. C., et al. (2001) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2001.4911233.x · Cited by 167 · see citing works
Kim, H., Suzuki, T., Yoshida, Y., & Yoshida, H. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01447.x · Cited by 101 · see citing works
Self-citationTengvall, M., Ellegård, L., Malmros, V., Bosaeus, N., Lissner, L., & Bosaeus, I. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2008.10.005 · Cited by 87 · see citing works
Body Mass Index and Nine‐Year Mortality in Disabled and Nondisabled Older U.S. Individuals
Kulminski, A. M., Arbeev, K. G., Culminskaya, I. V., Ukraintseva, S. V., Land, K. C., Akushevich, I. V., & Yashin, A. I. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01494.x · Cited by 79 · see citing works
Herman, A., Botser, I. B., Tenenbaum, S. A., & Chechick, A. (2009) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.h.01481 · Cited by 74 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sarcopenia in Asia: Consensus Report of the Asian Working Group for Sarcopenia
Chen, L.-K., Liu, L.-K., Woo, J., Assantachai, P., Auyeung, T.-W., Bahyah, K. S., Chou, M.-Y., Chen, L.-Y., Hsu, P.-S., Krairit, O., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.11.025 · Cited by 4,051 · see citing works
Self-citationBauer, J., Biolo, G., Cederholm, T., Cesari, M., Cruz-Jentoft, A. J., Morley, J. E., Phillips, S., Sieber, C., Stehle, P., Teta, D., et al. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.021 · Cited by 2,553 · see citing works
Cruz-Jentoft, A. J., Landi, F., Schneider, S. M., Zuniga, C., Arai, H., Boirie, Y., Chen, L.-K., Fielding, R. A., Martin, F. C., Michel, J.-P., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu115 · Cited by 1,963 · see citing works
Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738 · see citing works
International exercise recommendations in older adults (ICFSR): Expert consensus guidelines
Izquierdo, M., Merchant, R. A., Morley, J. E., Anker, S. D., Aprahamian, I., Arai, H., Aubertin-Leheudre, M., Bernabei, R., Cadore, E. L., Cesari, M., et al. (2021) · The Journal of nutrition, health and aging · doi:10.1007/s12603-021-1665-8 · Cited by 1,247 · see citing works
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., Bauer, J. M., Pahor, M., Clark, B. C., Cesari, M., et al. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1139-9 · Cited by 1,130 · see citing works
Cadore, E. L., Rodríguez-Mañas, L., Sinclair, A., & Izquierdo, M. (2013) · Rejuvenation Research · doi:10.1089/rej.2012.1397 · Cited by 954 · see citing works
The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty
Dent, E., Lien, C. T. C., Lim, W. S., Wong, W. C., Wong, C. H., Ng, T. P., Woo, J., Dong, B., de la Vega, S., Poi, P. J. H., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.04.018 · Cited by 634 · see citing works
Nutrition and physical activity in the prevention and treatment of sarcopenia: systematic review.
the IOF-ESCEO Sarcopenia Working Group, Beaudart, C., Dawson, A., Shaw, S. C., Harvey, N. C., Kanis, J. A., Binkley, N., Reginster, J. Y., Chapurlat, R., Chan, D. C., et al. (2017) · Osteoporosis International · doi:10.1007/s00198-017-3980-9 · Cited by 602 · see citing works
Cadore, E. L., Casas-Herrero, A., Zambom-Ferraresi, F., Idoate, F., Millor, N., Gómez, M., Rodriguez-Mañas, L., & Izquierdo, M. (2014) · AGE · doi:10.1007/s11357-013-9586-z · Cited by 526 · see citing works
Rondanelli, M., Klersy, C., Terracol, G., Talluri, J., Maugeri, R., Guido, D., Faliva, M. A., Solerte, B. S., Fioravanti, M., Lukaski, H., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.113357 · Cited by 412 · see citing works
Sarcopenia, frailty and their prevention by exercise
Nascimento, C. M., Ingles, M., Salvador-Pascual, A., Cominetti, M. R., Gomez-Cabrera, M. C., & Viña, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.035 · Cited by 396 · see citing works
Yoshimura, Y., Wakabayashi, H., Yamada, M., Kim, H., Harada, A., & Arai, H. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.03.019 · Cited by 365 · see citing works
Self-citationRobinson, S. M., Denison, H. J., Cooper, C. C., & Sayer, A. A. (2015) · Clinical Interventions in Aging · doi:10.2147/cia.s55842 · Cited by 341 · see citing works
Benefits of resistance training in physically frail elderly: a systematic review
Lopez, P., Pinto, R. S., Radaelli, R., Rech, A., Grazioli, R., Izquierdo, M., & Cadore, E. L. (2018) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0863-z · Cited by 338 · see citing works
A Review on Aging, Sarcopenia, Falls, and Resistance Training in Community-Dwelling Older Adults
Rodrigues, F., Domingos, C., Monteiro, D., & Morouço, P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19020874 · Cited by 362 · see citing works
A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease
Marty, E., Liu, Y., Samuel, A. M., Or, O., & Lane, J. (2017) · Bone · doi:10.1016/j.bone.2017.09.008 · Cited by 291 · see citing works
Strength and Endurance Training Prescription in Healthy and Frail Elderly
Cadore, E. L. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500183 · Cited by 273 · see citing works
Izquierdo, M., de Souto Barreto, P., Arai, H., Bischoff-Ferrari, H. A., Cadore, E. L., Cesari, M., Chen, L.-K., Coen, P. M., Courneya, K. S., Duque, G., et al. (2025) · The Journal of nutrition, health and aging · doi:10.1016/j.jnha.2024.100401 · Cited by 273 · see citing works
Hsu, K.-J., Liao, C.-D., Tsai, M.-W., & Chen, C.-N. (2019) · Nutrients · doi:10.3390/nu11092163 · Cited by 258 · see citing works
Regulation of Skeletal Muscle Function by Amino Acids
Kamei, Y., Hatazawa, Y., Uchitomi, R., Yoshimura, R., & Miura, S. (2020) · Nutrients · doi:10.3390/nu12010261 · Cited by 254 · see citing works
Lu, L., Mao, L., Feng, Y., Ainsworth, B. E., Liu, Y., & Chen, N. (2021) · BMC Geriatrics · doi:10.1186/s12877-021-02642-8 · Cited by 273 · see citing works
Malafarina, V., Úriz‐Otano, F., Iniesta, R. R., & Gil‐Guerrero, L. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.08.001 · Cited by 231 · see citing works
Vlietstra, L., Hendrickx, W., & Waters, D. L. (2018) · Australasian Journal on Ageing · doi:10.1111/ajag.12521 · Cited by 216 · see citing works
Exercise and nutrition strategies to counteract sarcopenic obesity
Trouwborst, I., Verreijen, A., Memelink, R., Massanet, P., Boirie, Y., Weijs, P., & Tieland, M. (2018) · Nutrients · doi:10.3390/nu10050605 · Cited by 210 · see citing works
Grgic, J., Garofolini, A., Orazem, J., Sabol, F., Schoenfeld, B. J., & Pedisic, Z. (2020) · Sports Medicine · doi:10.1007/s40279-020-01331-7 · Cited by 208 · see citing works
The intensive care medicine research agenda in nutrition and metabolism
Arabi, Y. M., Casaer, M. P., Chapman, M. J., Heyland, D. K., Ichaï, C., Marik, P. E., Martindale, R. G., McClave, S. A., Preiser, J., Reignier, J., et al. (2017) · Intensive Care Medicine · doi:10.1007/s00134-017-4711-6 · Cited by 203 · see citing works
Kim, H., Kim, M., Kojima, N., Fujino, K., Hosoi, E., Kobayashi, H., Somekawa, S., Niki, Y., Yamashiro, Y., & Yoshida, H. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.06.016 · Cited by 186 · see citing works
Self-citationRomán, E. M., Torrades, M. T., Nadal, M. J., Cárdenas, G., Nieto, J. C., Vidal, S., Bascuñana, H., Juárez, C., Guarner, C., Córdoba, J., et al. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-014-3086-6 · Cited by 197 · see citing works
The role of dietary protein intake in the prevention of sarcopenia of aging
Beasley, J. M., Shikany, J., & Thomson, C. (2013) · Nutrition in clinical practice · doi:10.1177/0884533613507607 · Cited by 183 · see citing works
Liao, C.-D., Chen, H.-C., Huang, S.-W., & Liou, T.-H. (2019) · Nutrients · doi:10.3390/nu11081713 · Cited by 189 · see citing works
Bao, W., Sun, Y. T., Zhang, T., Zou, L., Wu, X., Wang, D., & Chen, Z. (2020) · Aging and Disease · doi:10.14336/ad.2019.1012 · Cited by 228 · see citing works
Finger, D., Goltz, F. R., Umpierre, D., Meyer, E., Rosa, L. H. T., & Schneider, C. D. (2015) · Sports Medicine · doi:10.1007/s40279-014-0269-4 · Cited by 185 · see citing works
Talar, K., Hernández‐Belmonte, A., Větrovský, T., Šteffl, M., Kałamacka, E., & Courel‐Ibáñez, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081630 · Cited by 185 · see citing works
Association between sarcopenia and pneumonia in older people
Okazaki, T., Ebihara, S., Mori, T., Izumi, S., & Ebihara, T. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13839 · Cited by 184 · see citing works
Physical Activity and Sarcopenic Obesity: Definition, Assessment, Prevalence and Mechanism
Lee, D.-C., Shook, R. P., Drenowatz, C., & Blair, S. N. (2016) · Future Science OA · doi:10.4155/fsoa-2016-0028 · Cited by 177 · see citing works
Nakajima, H., Yokoyama, Y., Inoue, T., Nagaya, M., Mizuno, Y., Kadono, I., Nishiwaki, K., Nishida, Y., & Nagino, M. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6943-2 · Cited by 175 · see citing works
From sarcopenia to frailty: a road less traveled
Morley, J. E., von Haehling, S., Anker, S. D., & Vellas, B. J. (2014) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-014-0132-3 · Cited by 172 · see citing works
Wu, P.-Y., Huang, K.-S., Chen, K.-M., Chou, C.-P., & Tu, Y.-K. (2021) · Maturitas · doi:10.1016/j.maturitas.2020.12.009 · Cited by 168 · see citing works
Protein and exercise in the prevention of sarcopenia and aging
Naseeb, M. A., & Volpe, S. L. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.01.001 · Cited by 160 · see citing works
Inoue, T., Maeda, K., Nagano, A., Shimizu, A., Ueshima, J., Murotani, K., Sato, K., & Tsubaki, A. (2020) · Nutrients · doi:10.3390/nu12123743 · Cited by 164 · see citing works
Kim, H., Suzuki, T., Saito, K., Yoshida, H., Kojima, N., Kim, M., Sudo, M., Yamashiro, Y., & Tokimitsu, I. (2012) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2012.00923.x · Cited by 164 · see citing works
Self-citationKim, H., Hirano, H., Edahiro, A., Ohara, Y., Watanabe, Y., Kojima, N., Kim, M., Hosoi, E., Yoshida, Y., Yoshida, H., et al. (2016) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12723 · Cited by 164 · see citing works
Self-citationBukhari, S. S. I., Phillips, B. E., Wilkinson, D. J., Limb, M. C., Rankin, D., Mitchell, W. K., Kobayashi, H., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00481.2014 · Cited by 162 · see citing works
Self-citationKomar, B., Schwingshackl, L., & Hoffmann, G. (2015) · The Journal of nutrition, health and aging · doi:10.1007/s12603-014-0559-4 · Cited by 161 · see citing works
Nishigori, T., Okabe, H., Tanaka, E. I., Tsunoda, S., Hisamori, S., & Sakai, Y. (2016) · Journal of Surgical Oncology · doi:10.1002/jso.24214 · Cited by 155 · see citing works
Therapeutic Interventions for Frail Elderly Patients: Part I. Published Randomized Trials
Bibas, L., Levi, M., Bendayan, M., Mullie, L., Forman, D. E., & Afilalo, J. (2014) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.07.004 · Cited by 150 · see citing works
Management of Sarcopenia: A Network Meta-Analysis of Randomized Controlled Trials
Negm, A. M., Lee, J., Hamidian, R., Jones, C. A., & Khadaroo, R. G. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.01.057 · Cited by 137 · see citing works
Tsekoura, M., Billis, E., Tsepis, E., Dimitriadis, Z., Matzaroglou, C., Tyllianakis, M., Panagiotopoulos, E., & Gliatis, J. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7120480 · Cited by 142 · see citing works
Cao, L., Chen, S. C. J., Zou, C., Ding, X., Gao, L., Liao, Z., Liu, G., Malmstrom, T. K., Morley, J. E., Flaherty, J. H., et al. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0410-3 · Cited by 142 · see citing works
Muscle Wasting and Sarcopenia in Heart Failure—The Current State of Science
Lena, A., Anker, M. S., & Springer, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186549 · Cited by 140 · see citing works
Yamada, M., Kimura, Y., Ishiyama, D., Nishio, N., Otobe, Y., Tanaka, T., Ohji, S., Koyama, S., Sato, A., Suzuki, M., et al. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13643 · Cited by 143 · see citing works
Pediatric Sarcopenia: A Paradigm in the Overall Definition of Malnutrition in Children?
Ooi, P. H., Thompson‐Hodgetts, S., Pritchard, L., Gilmour, S. M., & Mager, D. R. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1681 · Cited by 140 · see citing works
Xu, Z.-R., Tan, Z.-J., Zhang, Q., Gui, Q.-F., & Yang, Y.-M. (2015) · British Journal of Nutrition · doi:10.1017/s0007114514002475 · Cited by 136 · see citing works
Hiraoka, A., Michitaka, K., Kiguchi, D., Izumoto, H., Ueki, H., Kaneto, M., Kitahata, S., Aibiki, T., Okudaira, T., Tomida, H., et al. (2017) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000986 · Cited by 134 · see citing works
Nutritional Interventions for Elderly and Considerations for the Development of Geriatric Foods
Kaur, D., Rasane, P., Singh, J., Kaur, S., Kumar, V., Mahato, D. K., Dey, A., Dhawan, K., & Kumar, S. (2019) · Current Aging Science · doi:10.2174/1874609812666190521110548 · Cited by 134 · see citing works
Kim, H., Suzuki, T., Kim, M., Kojima, N., Yoshida, Y., Hirano, H., Saito, K., Iwasa, H., Shimada, H., Hosoi, E., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.10.006 · Cited by 131 · see citing works
Self-citationLozano-Montoya, I., Correa-Pérez, A., Abraha, I., Soiza, R. L., Cherubini, A., O'Mahony, D., & Cruz-Jentoft, A. J. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s132496 · Cited by 130 · see citing works
Nishida, Y., Kato, Y., Kudo, M., Aizawa, H., Okubo, S., Takahashi, D., Nakayama, Y., Kitaguchi, K., Gotohda, N., Takahashi, S., et al. (2016) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-016-3146-7 · Cited by 129 · see citing works
Sarcopenia in Menopausal Women: Current Perspectives
Buckinx, F., & Aubertin‐Leheudre, M. (2022) · International Journal of Women s Health · doi:10.2147/ijwh.s340537 · Cited by 130 · see citing works
Lifestyle and Sarcopenia – Etiology, Prevention and Treatment
Rom, O., Kaisari, S., Aizenbud, D., & Reznick, A. Z. (2012) · Rambam Maimonides Medical Journal · doi:10.5041/rmmj.10091 · Cited by 130 · see citing works
Beneficial Effects of Leucine Supplementation on Criteria for Sarcopenia: A Systematic Review
Martínez‐Arnau, F. M., Fonfría-Vivas, R., & Cauli, O. (2019) · Nutrients · doi:10.3390/nu11102504 · Cited by 130 · see citing works
Wilkinson, D. J., Bukhari, S. S. I., Phillips, B. E., Limb, M. C., Cegielski, J., Brook, M. S., Rankin, D., Mitchell, W. K., Kobayashi, H., Williams, J. P., et al. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.008 · Cited by 128 · see citing works
Self-citationThe pathogenetic bases of sarcopenia
Budui, S. L. (2015) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2015.12.1.022 · Cited by 128 · see citing works
Ishibashi, H. (2018) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2018.09.004 · Cited by 127 · see citing works
Sarcopenia and fatty liver disease
Kim, J. A., & Choi, K. M. (2019) · Hepatology International · doi:10.1007/s12072-019-09996-7 · Cited by 127 · see citing works
Nabuco, H. C. G., Tomeleri, C. M., Fernandes, R. R., Sugihara Junior, P., Cavalcante, E. F., Cunha, P. M., Antunes, M., Nunes, J. P., Venturini, D., Barbosa, D. S., et al. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.04.007 · Cited by 125 · see citing works
Tieland, M., Franssen, R., Dullemeijer, C., van Dronkelaar, C., Kim, H. K., Ispoglou, T., Zhu, K., Prince, R. L., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-017-0896-1 · Cited by 123 · see citing works
Self-citationEffects of Leucine Administration in Sarcopenia: A Randomized and Placebo-controlled Clinical Trial
Martínez-Arnau, F. M., Fonfría-Vivas, R., Buigues, C., Castillo, Y., Molina, P., Hoogland, A. J., van Doesburg, F., Pruimboom, L., Fernández-Garrido, J., & Cauli, O. (2020) · Nutrients · doi:10.3390/nu12040932 · Cited by 120 · see citing works
Cadore, E. L., Sáez de Asteasu, M. L., & Izquierdo, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.04.007 · Cited by 112 · see citing works
Reijnierse, E. M., de van der Schueren, M. A. E., Trappenburg, M. C., Doves, M., Meskers, C. G. M., & Maier, A. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185837 · Cited by 116 · see citing works
Thomas, D. K., Quinn, M. A., Saunders, D. H., & Greig, C. A. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.07.002 · Cited by 108 · see citing works
Hiraoka, A., Aibiki, T., Okudaira, T., Toshimori, A., Kawamura, T., Nakahara, H., Suga, Y., Azemoto, N., Miyata, H., Miyamoto, Y., et al. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-015-1068-x · Cited by 107 · see citing works
Casas-Herrero, A., Cadore, E. L., Zambom-Ferraresi, F., Idoate, F., Millor, N., Martínez-Ramirez, A., Gómez, M., Rodriguez-Mañas, L., Marcellán, T., de Gordoa, A. R., et al. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1438 · Cited by 105 · see citing works
Kouw, I. W. K., Holwerda, A. M., Trommelen, J., Kramer, I. F., Bastiaanse, J., Halson, S. L., Wodzig, W. K. W. H., Verdijk, L. B., & van Loon, L. J. C. (2017) · Journal of Nutrition · doi:10.3945/jn.117.254532 · Cited by 107 · see citing works
Wang, H., Huang, W. Y., & Zhao, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19138212 · Cited by 99 · see citing works
Izquierdo, M., & Cadore, E. L. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.908175 · Cited by 97 · see citing works
Integrated care for geriatric frailty and sarcopenia: a randomized control trial
Chan, D., Tsou, H., Chang, C., Yang, R., Tsauo, J., Chen, C., Hsiao, C., Hsu, Y., Chen, C., Chang, S., et al. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12132 · Cited by 97 · see citing works
Yanai, H. (2015) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2361w · Cited by 96 · see citing works
Human Skeletal Muscle Protein Metabolism Responses to Amino Acid Nutrition
Mitchell, W. K., Wilkinson, D. J., Phillips, B. E., Lund, J. N., Smith, K., & Atherton, P. J. (2016) · Advances in Nutrition · doi:10.3945/an.115.011650 · Cited by 95 · see citing works
Shibahashi, K., Sugiyama, K., Kashiura, M., & Hamabe, Y. (2017) · Journal of Intensive Care · doi:10.1186/s40560-016-0205-9 · Cited by 92 · see citing works
Common Ground? The Concordance of Sarcopenia and Frailty Definitions
Reijnierse, E. M., Trappenburg, M. C., Blauw, G. J., Verlaan, S., de van der Schueren, M. A. E., Meskers, C. G. M., & Maier, A. B. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.01.013 · Cited by 91 · see citing works
Yamada, M., Nishiguchi, S., Fukutani, N., Aoyama, T., & Arai, H. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.02.017 · Cited by 85 · see citing works
Uemura, K., Doi, T., Lee, S., & Shimada, H. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.06.011 · Cited by 90 · see citing works
Hou, L., Lei, Y., Li, X., Huo, C., Jia, X.-M., Yang, J., Xu, R., & Wang, X. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1181-2 · Cited by 88 · see citing works
Efficacy and Safety of Leucine Supplementation in the Elderly
Borack, M. S., & Volpi, E. (2016) · Journal of Nutrition · doi:10.3945/jn.116.230771 · Cited by 89 · see citing works
Nutrition in the intensive care unit: from the acute phase to beyond
de Man, A., Gunst, J., & Blaser, A. R. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07458-9 · Cited by 94 · see citing works
Physical Activity and Aging Research: A Bibliometric Analysis
Müller, A. M., Ansari, P., Ebrahim, N. A., & Khoo, S. (2015) · Journal of Aging and Physical Activity · doi:10.1123/japa.2015-0188 · Cited by 106 · see citing works
Clinical Screening Tools for Sarcopenia and Its Management
Yu, S., Khow, K. S. F., Jadczak, A. D., & Visvanathan, R. (2016) · Current Gerontology and Geriatrics Research · doi:10.1155/2016/5978523 · Cited by 85 · see citing works
Exercise as a treatment for sarcopenia: an umbrella review of systematic review evidence
Moore, S. A., Hrisos, N., Errington, L., Rochester, L., Rodgers, H., Witham, M. D., & Sayer, A. A. (2019) · Physiotherapy · doi:10.1016/j.physio.2019.08.005 · Cited by 81 · see citing works
Protein Source and Muscle Health in Older Adults: A Literature Review
Putra, C., Konow, N., Gage, M. J., York, C., & Mangano, K. M. (2021) · Nutrients · doi:10.3390/nu13030743 · Cited by 86 · see citing works
Liu, C.-J., Chang, W., de Carvalho, I. A., Savage, K. E. L., Radford, L. W., & Thiyagarajan, J. A. (2017) · International Journal of Rehabilitation Research · doi:10.1097/mrr.0000000000000249 · Cited by 81 · see citing works
Yoshimura, Y., Uchida, K., Jeong, S., & Yamaga, M. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0570-4 · Cited by 81 · see citing works
de Mello, R. G. B., Dalla Corte, R. R., Gioscia, J., & Moriguchi, E. H. (2019) · Journal of Aging Research · doi:10.1155/2019/1959486 · Cited by 79 · see citing works
Plotkin, D. L., Delcastillo, K., Van Every, D. W., Tipton, K. D., Aragon, A. A., & Schoenfeld, B. J. (2021) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2020-0356 · Cited by 80 · see citing works
Dietary Protein and Amino Acid Intake: Links to the Maintenance of Cognitive Health
Glenn, J., Madero, E., & Bott, N. (2019) · Nutrients · doi:10.3390/nu11061315 · Cited by 63 · see citing works
Ratnayake, B., Loveday, B. P. T., Shrikhande, S. V., Windsor, J. A., & Pandanaboyana, S. (2018) · Pancreatology · doi:10.1016/j.pan.2018.09.011 · Cited by 77 · see citing works
Vitamin E in Sarcopenia: Current Evidences on Its Role in Prevention and Treatment
Khor, S. C., Karim, N. A., Ngah, W. Z. W., Yusof, Y. A. M., & Makpol, S. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/914853 · Cited by 77 · see citing works
Risk factors associated with low handgrip strength in the older Korean population
Kim, C. R., Jeon, Y., & Jeong, T. H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214612 · Cited by 76 · see citing works
Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations
Hida, T. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500226 · Cited by 75 · see citing works
- Authors
- Kim, H. K., Suzuki, T., Saito, K., Yoshida, H., Kobayashi, H., Kato, H., & Katayama, M.
- Affiliations
- Tokyo Metropolitan Institute of Gerontology (JP)
- National Institute for Longevity Sciences Aichi Japan
- Ajinomoto (Japan) (JP)
- Corresponding author
- Kim, Hun Kyung
- Venue
- Journal of the American Geriatrics Society
- Publisher
- Wiley
- Published
- 2011-12-05
- Volume
- 60
- Issue
- 1
- Pages
- 16-23
- ISSN
- 0002-8614 (ISSN-L)
- 1532-5415
- OpenAlex
- W2074524235
- Cited by
- 551
- References
- 37
- Citations by year
- 2026: 25 · 2025: 36 · 2024: 33 · 2023: 44 · 2022: 47 · 2021: 51 · 2020: 51 · 2019: 57 · 2018: 45 · 2017: 45 · 2016: 36 · 2015: 31 · 2014: 26 · 2013: 16 · 2012: 7
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Geriatrics Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (22300243)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, older women, exercise training, amino acid supplementation, muscle mass, muscle strength, walking speed, quadriceps strength, body composition, community-dwelling older adults, health education
- MeSH terms
- Aged, Amino Acids, Essential, Body Composition, Exercise Therapy, Female, Follow-Up Studies, Humans, Japan, Motor Activity, Patient Education as Topic, Retrospective Studies, Exercise, Geriatric Assessment, Incidence, Treatment Outcome, Dietary Supplements, Muscle Strength, Sarcopenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
