Intracellular free amino acid concentration in human muscle tissue.

From Krebs to clinic: glutamine metabolism to cancer therapy

Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works

Hypoalbuminemia: Pathogenesis and Clinical Significance

Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448 · see citing works

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

DeBerardinis, R. J., & Cheng, T. (2010) · Oncogene · doi:10.1038/onc.2009.358 · Cited by 1,365 · see citing works

Glutamine and cancer: cell biology, physiology, and clinical opportunities

Hensley, C. T., Wasti, A. T., & DeBerardinis, R. J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69600 · Cited by 1,262 · see citing works

Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle

Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · see citing works

An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein

Biolo, G., Tipton, K. D., Klein, S., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e122 · Cited by 825 · see citing works

Postexercise net protein synthesis in human muscle from orally administered amino acids

Tipton, K. D., Ferrando, A. A., Phillips, S. M., Doyle, D., & Wolfe, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.4.e628 · Cited by 616 · see citing works

Effect of age on <i>in vivo</i> rates of mitochondrial protein synthesis in human skeletal muscle

Rooyackers, O. E., Adey, D. B., Ades, P. A., & Nair, K. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.26.15364 · Cited by 564 · see citing works

Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise

Tipton, K. D., Rasmussen, B. B., Miller, S. L., Wolf, S. E., Owens-Stovall, S. K., Petrini, B. E., & Wolfe, R. R. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.281.2.e197 · Cited by 526 · see citing works

Amino acid ingestion improves muscle protein synthesis in the young and elderly

Paddon-Jones, D., Sheffield-Moore, M., Zhang, X.-J., Volpi, E., Wolf, S. E., Aarsland, A., Ferrando, A. A., & Wolfe, R. R. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00368.2003 · Cited by 467 · see citing works

Tumor glycolysis, an essential sweet tooth of tumor cells

Paul, S., Ghosh, S., & Kumar, S. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.09.007 · Cited by 449 · see citing works

Physiologic hyperinsulinemia stimulates protein synthesis and enhances transport of selected amino acids in human skeletal muscle

Biolo, G., Declan Fleming, R. Y., & Wolfe, R. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117731 · Cited by 442 · see citing works

Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

Atherton, P. J., Etheridge, T., Watt, P. W., Wilkinson, D., Selby, A., Rankin, D., Smith, K., & Rennie, M. J. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29819 · Cited by 404 · see citing works

Essential Amino Acid and Carbohydrate Supplementation Ameliorates Muscle Protein Loss in Humans during 28 Days Bedrest

Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Sanford, A. P., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2004) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2003-032159 · Cited by 338 · see citing works

Independent and Combined Effects of Amino Acids and Glucose after Resistance Exercise

MILLER, S. L., TIPTON, K. D., CHINKES, D. L., WOLF, S. E., & WOLFE, R. R. (2003) · Medicine &amp; Science in Sports &amp; Exercise · doi:10.1249/01.mss.0000053910.63105.45 · Cited by 283 · see citing works

Atrophy and Impaired Muscle Protein Synthesis during Prolonged Inactivity and Stress

Paddon-Jones, D., Sheffield-Moore, M., Cree, M. G., Hewlings, S. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2006) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2006-0651 · Cited by 254 · see citing works

Testosterone injection stimulates net protein synthesis but not tissue amino acid transport

Ferrando, A. A., Tipton, K. D., Doyle, D., Phillips, S. M., Cortiella, J., & Wolfe, R. R. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.5.e864 · Cited by 256 · see citing works

Aging does not impair the anabolic response to a protein-rich meal

Symons, T. B., Schutzler, S. E., Cocke, T. L., Chinkes, D. L., Wolfe, R. R., & Paddon-Jones, D. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.2.451 · Cited by 240 · see citing works

Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism

Bott, A. J., Shen, J., Tonelli, C., Zhan, L., Sivaram, N., Jiang, Y.-P., Yu, X., Bhatt, V., Chiles, E., Zhong, H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.056 · Cited by 185 · see citing works

Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion

Tipton, K. D., Borsheim, E., Wolf, S. E., Sanford, A. P., & Wolfe, R. R. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00234.2002 · Cited by 193 · see citing works

Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach

Chen, L., & Cui, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922830 · Cited by 184 · see citing works

Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content

Katsanos, C. S., Chinkes, D. L., Paddon-Jones, D., Zhang, X.-J., Aarsland, A., & Wolfe, R. R. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.06.007 · Cited by 159 · see citing works

The metabolic effects of thermal injury

Tredget, E. E., & Yu, Y. M. (1992) · World Journal of Surgery · doi:10.1007/bf02067117 · Cited by 149 · see citing works

Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity

Symons, T. B., Sheffield-Moore, M., Chinkes, D. L., Ferrando, A. A., & Paddon-Jones, D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91137.2008 · Cited by 111 · see citing works

Kinetic Analysis of Intracellular Concentrations of Reactive Nitrogen Species

Lim, C. H., Dedon, P. C., & Deen, W. M. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800213b · Cited by 93 · see citing works

Pronounced energy restriction with elevated protein intake results in no change in proteolysis and reductions in skeletal muscle protein synthesis that are mitigated by resistance exercise

Hector, A. J., McGlory, C., Damas, F., Mazara, N., Baker, S. K., & Phillips, S. M. (2018) · The FASEB Journal · doi:10.1096/fj.201700158rr · Cited by 91 · see citing works

p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates

Nguyen, T. V., Li, J., Lu, C.-C. (., Mamrosh, J. L., Lu, G., Cathers, B. E., & Deshaies, R. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700949114 · Cited by 85 · see citing works

Optimizing human in vivo dosing and delivery of β-alanine supplements for muscle carnosine synthesis

Stellingwerff, T., Decombaz, J., Harris, R. C., & Boesch, C. (2012) · Amino Acids · doi:10.1007/s00726-012-1245-7 · Cited by 85 · see citing works

Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism

Cacace, A., Sboarina, M., Vazeille, T., & Sonveaux, P. (2017) · Oncogene · doi:10.1038/onc.2016.364 · Cited by 76 · see citing works

Resistance training preserves fat-free mass without impacting changes in protein metabolism after weight loss in older women

Campbell, W. W., Haub, M. D., Wolfe, R. R., Ferrando, A. A., Sullivan, D. H., Apolzan, J. W., & Iglay, H. B. (2009) · Obesity · doi:10.1038/oby.2009.2 · Cited by 74 · see citing works

Amino Acid Mixture Improves Training Efficiency in Athletes

Ohtani, M., Sugita, M., & Maruyama, K. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.2.538s · Cited by 58 · see citing works

The Catabolic Effects of Prolonged Inactivity and Acute Hypercortisolemia Are Offset by Dietary Supplementation

Paddon-Jones, D., Sheffield-Moore, M., Urban, R. J., Aarsland, A., Wolfe, R. R., & Ferrando, A. A. (2005) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2004-1702 · Cited by 52 · see citing works

Molecular crowding favors reactivity of a human ribozyme under physiological ionic conditions

Strulson, C. A., Yennawar, N. H., Rambo, R. P., & Bevilacqua, P. C. (2013) · Biochemistry · doi:10.1021/bi400816s · Cited by 46 · see citing works