Cited by 351Bone health and osteoporosis researchHIV-related health complications and treatmentsBody Composition Measurement Techniques

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Reciprocal Relations of Subcutaneous and Visceral Fat to Bone Structure and Strength

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Gilsanz, Vicente, Chalfant, James, Mo, Ashley O., Lee, David C., Dorey, Frederick J., Mittelman, Steven D.·2009·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2008-2422PMC PMC2741723

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Abstract

CONTEXT: Increased body fat is a risk factor for cardiovascular and metabolic disease, yet it is uncertain whether obesity protects against osteoporosis or adiposity is harmful to bone. OBJECTIVE: The aim of the study was to assess whether the pattern of adipose tissue deposition influences bone structure and strength. DESIGN: The relations between sc and visceral adiposity and the cross-sectional dimensions and polar and principal moments of the femur in 100 healthy women ages 15 to 25 years were obtained using computed tomography. RESULTS: Multiple linear regression analyses indicated that, after adjusting for leg length and thigh musculature, both sc and visceral fat had strong and independent associations with femoral cross-sectional area, cortical bone area, principal moment maximum, principal moment minimum, and polar moment (all P values < 0.03). However, whereas sc fat had a positive predictive value with all femoral bone phenotypes, a similar but negative effect was observed between visceral fat and these measures (all P values < 0.01). CONCLUSIONS: We found that visceral and sc fat have opposite effects on the appendicular skeleton; whereas sc fat is beneficial to bone structure and strength, visceral fat serves as an unique pathogenic fat depot.

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1 retracted

Body fat distribution, the menopause transition, and hormone replacement therapy.
Tchernof, A., Poehlman, É. T., & Després, J. (2000) · PubMed · Cited by 124
Retracted
Regression Diagnostics: Identifying Influential Data and Sources of Collinearity
Belsley, D. A., Kuh, E., & Welsch, R. E. (1980) · Wiley Series in Probability and Statistics · doi:10.1002/0471725153 · Cited by 7,297
RADIOGRAPHIC ATLAS OF SKELETAL DEVELOPMENT OF THE HAND AND WRIST
GREULICH, W. W., & Pyle, S. I. (1959) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195909000-00030 · Cited by 5,562
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart Study
Fox, C. S., Massaro, J. M., Hoffmann, U., Pou, K. M., Maurovich-Horvat, P., Liu, C.-Y., Vasan, R. S., Murabito, J. M., Meigs, J. B., Cupples, L. A., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.675355 · Cited by 2,882
Increased visceral fat and decreased energy expenditure during the menopausal transition
Lovejoy, J. C., Champagne, C. M., de Jonge, L., Xie, H., & Smith, S. R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.25 · Cited by 1,020
Mechanisms of Disease: is osteoporosis the obesity of bone?
Rosen, C. J., & Bouxsein, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0070 · Cited by 974
Visceral and Subcutaneous Adipose Tissue Volumes Are Cross-Sectionally Related to Markers of Inflammation and Oxidative Stress
Pou, K. M., Massaro, J. M., Hoffmann, U., Vasan, R. S., Maurovich‐Horvat, P., Larson, M. G., Keaney, J. F., Meigs, J. B., Lipinska, I., Kathiresan, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.710509 · Cited by 915
Biochemical Markers of Bone Turnover, Endogenous Hormones and the Risk of Fractures in Postmenopausal Women: The OFELY Study
Garnero, P., Sornay-Rendu, E., Claustrat, B., & Delmas, P. D. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.8.1526 · Cited by 709
Relationships among body mass, its components, and bone11Published simultaneously at BoneKEy-Osteovision (http://www.bonekey-ibms.org), a Web site sponsored by the International Bone and Mineral Society.
Reid, I. R. (2002) · Bone · doi:10.1016/s8756-3282(02)00864-5 · Cited by 625
Association Between Regional Adipose Tissue Distribution and Both Type 2 Diabetes and Impaired Glucose Tolerance in Elderly Men and Women
Goodpaster, B. H., Krishnaswami, S., Resnick, H., Kelley, D. E., Haggerty, C., Harris, T. B., Schwartz, A. V., Kritchevsky, S., & Newman, A. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.372 · Cited by 619
Growth and Maturation during Adolescence
Tanner, J. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1981.tb06734.x · Cited by 539
Relationships between fat and bone
Reid, I. R. (2008) · Osteoporosis International · doi:10.1007/s00198-007-0492-z · Cited by 475
Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause
Haarbo, J., Marslew, U., Gotfredsen, A., & Christiansen, C. (1991) · Metabolism · doi:10.1016/0026-0495(91)90037-w · Cited by 442
Waist circumference and abdominal adipose tissue distribution: influence of age and sex
Kuk, J. L., Lee, S., Heymsfield, S. B., & Ross, R. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1330 · Cited by 355
Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk
Onat, A., Avcı, G. Ş., Barlan, M. M., Uyarel, H., Uzunlar, B. ⁄. L., & Sansoy, V. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802695 · Cited by 339
Serum leptin level is a regulator of bone mass
Elefteriou, F., Takeda, S., Ebihara, K., Magré, J., Patano, N., Kim, C. A., Ogawa, Y., Liu, X., Ware, S. M., Craigen, W. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308744101 · Cited by 335
Fat Mass Is Not Beneficial to Bone in Adolescents and Young Adults
Janicka, A., Wren, T. A. L., Sanchez, M., Dorey, F. J., Kim, P. S., Mittelman, S. D., & Gilsanz, V. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0794 · Cited by 287
Self-citation
Visceral Fat in Hypertension
Sironi, A. M., Gastaldelli, A., Mari, A., Ciociaro, D., Postano, V., Buzzigoli, E., Ghione, S., Turchi, S., Lombardi, M., & Ferrannini, E. (2004) · Hypertension · doi:10.1161/01.hyp.0000137982.10191.0a · Cited by 273
Effect of Obesity on Estradiol Level, and Its Relationship to Leptin, Bone Maturation, and Bone Mineral Density in Children
Klein, K. O., Larmore, K. A., de Lancey, E., Brown, J., Considine, R. V., & Hassink, S. G. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.10.5204 · Cited by 216
Evaluation of cortical bone by computed tomography
Hangartner, T. N., & Gilsanz, V. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650111019 · Cited by 214
Self-citation
Effective dose values in bone mineral measurements by photon absorptiometry and computed tomography
Kalender, W. A. (1992) · Osteoporosis International · doi:10.1007/bf01623841 · Cited by 212
Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women
Yamauchi, M., Sugimoto, T., Yamaguchi, T. F., Nakaoka, D., Kanzawa, M., Yano, S., Ozuru, R., Sugishita, T., & Chihara, K. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01361.x · Cited by 209
Adipose Tissue Stimulates Bone Growth in Prepubertal Children
Clark, E., Ness, A., & Tobias, J. H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0332 · Cited by 208
Cytokine-Related Aging Process
Morley, J. E., & Baumgartner, R. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.9.m924 · Cited by 189
Visceral Obesity and Plasma Glucose-Insulin Homeostasis: Contributions of Interleukin-6 and Tumor Necrosis Factor-α in Men
Cartier, A., Lemieux, I., Alméras, N., Tremblay, A., Bergeron, J., & Després, J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2191 · Cited by 165
Percent body fat and bone mass in healthy Canadian females 10 to 19 years of age
Weiler, H. A., Janzen, L. M., Green, K., Grabowski, J., Seshia, M. M. K., & Yuen, K. C. J. (2000) · Bone · doi:10.1016/s8756-3282(00)00314-8 · Cited by 141
Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life1
Loro, M. L., Sayre, J. W., Roe, T. F., Goran, M. I., KAUFMAN, F. R., & Gilsanz, V. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.10.6887 · Cited by 138
Self-citation
Lean Mass and Not Fat Mass Is Associated With Male Proximal Femur Strength
Travison, T. G., de Araújo, A. B., Esche, G. R., Beck, T., & McKinlay, J. B. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.071016 · Cited by 138
Effect of sex and age on bone mass, body composition and fuel metabolism in humans
Horber, F., Gruber, B., Thomi, F., Jensen, E. X., & Jaeger, P. (1997) · Nutrition · doi:10.1016/s0899-9007(97)00031-2 · Cited by 122
Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass
Gnudi, S., Sitta, E., & Fiumi, N. (2007) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-007-0758-8 · Cited by 121
Early Identification of Children Predisposed to Low Peak Bone Mass and Osteoporosis Later in Life
Loro, M. L. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.10.3908 · Cited by 121
Bone, Muscle, and Fat: Sex-related Differences in Prepubertal Children
Arfai, K., Pitukcheewanont, P., Goran, M. I., Tavaré, C. J., Heller, L., & Gilsanz, V. (2002) · Radiology · doi:10.1148/radiol.2242011369 · Cited by 110
Self-citation
Waist circumference, dual-energy X-ray absortiometrically measured abdominal adiposity, and computed tomographically derived intra-abdominal fat area on detecting metabolic risk factors in obese women
Lee, K., Lee, S. Y., Kim, Y., & Kim, Y. J. (2008) · Nutrition · doi:10.1016/j.nut.2008.03.004 · Cited by 105
The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFα in human adipocytes
Wood, I. S., Wang, B., Jenkins, J. R., & Trayhurn, P. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.068 · Cited by 94
Sensitivity associated with the identification of visceral adipose tissue levels using waist circumference in men and women: effects of weight loss.
Ross, R., Rissanen, J., & Hudson, R. (1996) · PubMed · Cited by 89
Relationships among body mass, its components, and bone
Reid, I. R. (2002) · BoneKEy-Osteovision · doi:10.1138/2002055 · Cited by 87
Sagittal diameter in comparison with single slice CT as a predictor of total visceral adipose tissue volume
Schoen, R., Thaete, F. L., Sankey, S., Weissfeld, J., & Kuller, L. H. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800591 · Cited by 86
Depot‐specific steroidogenic gene transcription in human adipose tissue
MacKenzie, S. M., Huda, S. S., Sattar, N. A., Fraser, R., Connell, J., & Davies, E. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03262.x · Cited by 83
Weight, Body Composition, and Bone Density in Postmenopausal Women
Harris, S. S., & Dawson‐Hughes, B. (1996) · Calcified Tissue International · doi:10.1007/bf00369205 · Cited by 73
Visceral fat accumulation as a predictor of coronary artery calcium as assessed by multislice computed tomography in Japanese patients
Ohashi, N., Yamamoto, H., Horiguchi, J., Kitagawa, T., Hirai, N., Ito, K., & Kohno, N. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.04.019 · Cited by 69
Contribution of Visceral Fat Accumulation to the Risk Factors for Atherosclerosis in Non-Obese Japanese
Miyawaki, T., Abe, M., Yahata, K., Kajiyama, N., Katsuma, H., & SAITO, N. (2004) · Internal Medicine · doi:10.2169/internalmedicine.43.1138 · Cited by 66
Abdominal fat and hip fracture risk in the elderly: The Dubbo Osteoporosis Epidemiology Study
Nguyen, N. D., Pongchaiyakul, C., Eisman, J. A., & Nguyen, T. V. (2005) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-6-11 · Cited by 62
Peak bone mineral area density and determinants among females aged 9 to 24�years in Mexico
Lazcano-Ponce, E. C., Tamayo, J., Cruz-Valdéz, A., D�az, R., Hern�ndez, B., Cueto, R. D., & Hernández‐Ávila, M. (2003) · Osteoporosis International · doi:10.1007/s00198-002-1363-2 · Cited by 55
Quantitative Computed Tomography Precision and Accuracy for Long-Term Follow-up of Bone Mineral Density Measurements
Braillon, P. M. (2002) · Journal of Clinical Densitometry · doi:10.1385/jcd:5:3:259 · Cited by 27
Differences in the Pathology of the Metabolic Syndrome With or Without Visceral Fat Accumulation
Mori, Y., Hoshino, K., Yokota, K., Itoh, Y., & Tajima, N. (2006) · Endocrine · doi:10.1385/endo:29:1:149 · Cited by 23
Precise Determination of Paraspinous Musculature by Quantitative CT
Steiger, P., Block, J. E., Friedlander, A. L., & Genant, H. K. (1988) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-198807000-00015 · Cited by 13

Research works printed but not linked: 1

Belsley, 1980, Regression diagnostics, Hoboken,, NJ, Wiley

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McComsey, G. A., Tebas, P., Shane, E. J., Yin, M. T., Overton, E. T., Huang, J. S., Aldrovandi, G. M., Cardoso, S. W., Santana, J. L., & Brown, T. T. (2010) · Clinical Infectious Diseases · doi:10.1086/656412 · Cited by 399
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Reid, I. R. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.027 · Cited by 368
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Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Rosen, C. J., Klibanski, A., & Miller, K. K. (2010) · Obesity · doi:10.1038/oby.2010.106 · Cited by 346
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Authors: Gilsanz, V., Chalfant, J., Mo, A. O., Lee, D. C., Dorey, F. J., & Mittelman, S. D.
Affiliations: University of Southern California (US)
Corresponding author: Gilsanz, Vicente
ORCID: Gilsanz, Vicente
Chalfant, James
Lee, David C.
Mittelman, Steven D.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2009-09-01
Volume: 94
Issue: 9
Pages: 3387-3393
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2008-2422
PMC: PMC2741723
OpenAlex: W1971193583
Cited by: 351
References: 45
Citations by year: 2026: 5 · 2025: 12 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 14 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 29 · 2016: 26 · 2015: 17 · 2014: 30 · 2013: 37 · 2012: 23
FWCI: 23.82
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052744)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Keywords: subcutaneous adipose tissue, visceral fat, body fat distribution, bone structure, bone strength, femur, cortical bone area, cross-sectional area, young women, osteoporosis risk
MeSH terms: Adolescent, Adult, Bone and Bones, Female, Humans, Tomography, X-Ray Computed, Linear Models, Subcutaneous Fat, Intra-Abdominal Fat

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Reciprocal Relations of Subcutaneous and Visceral Fat to Bone Structure and Strength

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