Cited by 351Bone health and osteoporosis researchHIV-related health complications and treatmentsBody Composition Measurement Techniques

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Reciprocal Relations of Subcutaneous and Visceral Fat to Bone Structure and Strength

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Gilsanz, Vicente, Chalfant, James, Mo, Ashley O., Lee, David C., Dorey, Frederick J., Mittelman, Steven D.·2009·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2008-2422PMC PMC2741723

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Abstract

CONTEXT: Increased body fat is a risk factor for cardiovascular and metabolic disease, yet it is uncertain whether obesity protects against osteoporosis or adiposity is harmful to bone. OBJECTIVE: The aim of the study was to assess whether the pattern of adipose tissue deposition influences bone structure and strength. DESIGN: The relations between sc and visceral adiposity and the cross-sectional dimensions and polar and principal moments of the femur in 100 healthy women ages 15 to 25 years were obtained using computed tomography. RESULTS: Multiple linear regression analyses indicated that, after adjusting for leg length and thigh musculature, both sc and visceral fat had strong and independent associations with femoral cross-sectional area, cortical bone area, principal moment maximum, principal moment minimum, and polar moment (all P values < 0.03). However, whereas sc fat had a positive predictive value with all femoral bone phenotypes, a similar but negative effect was observed between visceral fat and these measures (all P values < 0.01). CONCLUSIONS: We found that visceral and sc fat have opposite effects on the appendicular skeleton; whereas sc fat is beneficial to bone structure and strength, visceral fat serves as an unique pathogenic fat depot.

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Authors: Gilsanz, V., Chalfant, J., Mo, A. O., Lee, D. C., Dorey, F. J., & Mittelman, S. D.
Affiliations: University of Southern California (US)
Corresponding author: Gilsanz, Vicente
ORCID: Gilsanz, Vicente
Chalfant, James
Lee, David C.
Mittelman, Steven D.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2009-09-01
Volume: 94
Issue: 9
Pages: 3387-3393
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2008-2422
PMC: PMC2741723
OpenAlex: W1971193583
Cited by: 351
References: 45
Citations by year: 2026: 5 · 2025: 12 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 14 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 29 · 2016: 26 · 2015: 17 · 2014: 30 · 2013: 37 · 2012: 23
FWCI: 23.82
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052744)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Keywords: subcutaneous adipose tissue, visceral fat, body fat distribution, bone structure, bone strength, femur, cortical bone area, cross-sectional area, young women, osteoporosis risk
MeSH terms: Adolescent, Adult, Bone and Bones, Female, Humans, Tomography, X-Ray Computed, Linear Models, Subcutaneous Fat, Intra-Abdominal Fat

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Reciprocal Relations of Subcutaneous and Visceral Fat to Bone Structure and Strength

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