The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Reciprocal Relations of Subcutaneous and Visceral Fat to Bone Structure and Strength
Open accessAbstract
CONTEXT: Increased body fat is a risk factor for cardiovascular and metabolic disease, yet it is uncertain whether obesity protects against osteoporosis or adiposity is harmful to bone. OBJECTIVE: The aim of the study was to assess whether the pattern of adipose tissue deposition influences bone structure and strength. DESIGN: The relations between sc and visceral adiposity and the cross-sectional dimensions and polar and principal moments of the femur in 100 healthy women ages 15 to 25 years were obtained using computed tomography. RESULTS: Multiple linear regression analyses indicated that, after adjusting for leg length and thigh musculature, both sc and visceral fat had strong and independent associations with femoral cross-sectional area, cortical bone area, principal moment maximum, principal moment minimum, and polar moment (all P values < 0.03). However, whereas sc fat had a positive predictive value with all femoral bone phenotypes, a similar but negative effect was observed between visceral fat and these measures (all P values < 0.01). CONCLUSIONS: We found that visceral and sc fat have opposite effects on the appendicular skeleton; whereas sc fat is beneficial to bone structure and strength, visceral fat serves as an unique pathogenic fat depot.
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“Relative to body weight, microarchitecture and strength are lower in obese women compared to controls 23.”
From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [23]
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1 retracted
Body fat distribution, the menopause transition, and hormone replacement therapy.
Tchernof, A., Poehlman, É. T., & Després, J. (2000) · PubMed · Cited by 124
RetractedRegression Diagnostics: Identifying Influential Data and Sources of Collinearity
Belsley, D. A., Kuh, E., & Welsch, R. E. (1980) · Wiley Series in Probability and Statistics · doi:10.1002/0471725153 · Cited by 7,297
RADIOGRAPHIC ATLAS OF SKELETAL DEVELOPMENT OF THE HAND AND WRIST
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Increased visceral fat and decreased energy expenditure during the menopausal transition
Lovejoy, J. C., Champagne, C. M., de Jonge, L., Xie, H., & Smith, S. R. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.25 · Cited by 1,020
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Rosen, C. J., & Bouxsein, M. (2006) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0070 · Cited by 974
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Research works printed but not linked: 1
- Belsley, 1980, Regression diagnostics, Hoboken,, NJ, Wiley
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Compston, J. E., Watts, N. B., Chapurlat, R., Cooper, C., Boonen, S., Greenspan, S., Pfeilschifter, J., Silverman, S., Díez-Pérez, A., Lindsay, R., et al. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.06.013 · Cited by 552
Bone Disease in HIV Infection: A Practical Review and Recommendations for HIV Care Providers
McComsey, G. A., Tebas, P., Shane, E. J., Yin, M. T., Overton, E. T., Huang, J. S., Aldrovandi, G. M., Cardoso, S. W., Santana, J. L., & Brown, T. T. (2010) · Clinical Infectious Diseases · doi:10.1086/656412 · Cited by 399
Reid, I. R. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.06.027 · Cited by 368
Bredella, M. A., Torriani, M., Ghomi, R. H., Thomas, B. J., Brick, D. J., Gerweck, A. V., Rosen, C. J., Klibanski, A., & Miller, K. K. (2010) · Obesity · doi:10.1038/oby.2010.106 · Cited by 346
Bone Metabolism in Obesity and Weight Loss
Shapses, S. A., & Sukumar, D. (2012) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104655 · Cited by 358
Metadata
- Authors
- Gilsanz, V., Chalfant, J., Mo, A. O., Lee, D. C., Dorey, F. J., & Mittelman, S. D.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Gilsanz, Vicente
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2009-09-01
- Volume
- 94
- Issue
- 9
- Pages
- 3387-3393
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC2741723
- OpenAlex
- W1971193583
- Cited by
- 351
- References
- 45
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 14 · 2020: 23 · 2019: 13 · 2018: 17 · 2017: 29 · 2016: 26 · 2015: 17 · 2014: 30 · 2013: 37 · 2012: 23
- FWCI
- 23.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052744)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- subcutaneous adipose tissue, visceral fat, body fat distribution, bone structure, bone strength, femur, cortical bone area, cross-sectional area, young women, osteoporosis risk
- MeSH terms
- Adolescent, Adult, Bone and Bones, Female, Humans, Tomography, X-Ray Computed, Linear Models, Subcutaneous Fat, Intra-Abdominal Fat
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