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Cited by 314

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Place of Cabergoline in Acromegaly: A Meta-Analysis

Sandret, Laure, Maison, Patrick, Chanson, Philippe·2011·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2010-2443
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Abstract

Context: Cabergoline is widely considered to be poorly effective in acromegaly. Objective: The aim of this study was to obtain a more accurate picture of the efficacy of cabergoline in acromegaly, both alone and in combination with somatostatin analogs. Design: We systematically reviewed all trials of cabergoline therapy for acromegaly published up to 2009 in four databases (PubMed, Pascal, Embase, and Google Scholar). We identified 15 studies (11 prospective) with a total of 237 patients; none were randomized or placebo-controlled. A meta-analysis was conducted on individual data (n = 227). Results: Cabergoline was used alone in nine studies. Fifty-one (34%) of the 149 patients achieved normal IGF-I levels. In multivariate analysis, the decline in IGF-I was related to the baseline IGF-I concentration (β = 1.16; P <0.001), treatment duration (β = 0.28; P < 0.001), and baseline prolactin concentration (β = −0.18; P = 0.01), and with a trend toward a relation with the cabergoline dose (β = 0.38; P =0.07). In five studies, cabergoline was added to ongoing somatostatin analog treatment that had failed to normalize IGF-I. Forty patients (52%) achieved normal IGF-I levels. The change in IGF-I was significantly related to the baseline IGF-I level (β = 0.74; P < 0.001) but not to the dose of cabergoline, the duration of treatment, or the baseline prolactin concentration. Conclusion: This meta-analysis suggests that cabergoline single-agent therapy normalizes IGF-I levels in one third of patients with acromegaly. When a somatostatin analog fails to control acromegaly, cabergoline adjunction normalizes IGF-I in about 50% of cases. This effect may occur even in patients with normoprolactinemia.

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Metadata

Authors
Sandret, L., Maison, P., & Chanson, P.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2011-05-01
Volume
96
Issue
5
Pages
1327-1335
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2010-2443
OpenAlex
W1993154503
Cited by
314
References
38
FWCI
3.34
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Place of Cabergoline in Acromegaly: A Meta-Analysis. https://app.cochat.ai/papers/10.1210/jc.2010-2443
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Sandret, L., Maison, P., & Chanson, P. (2011). Place of Cabergoline in Acromegaly: A Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2010-2443

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.