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Cited by 178

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Low Free Testosterone Predicts Mortality from Cardiovascular Disease But Not Other Causes: The Health in Men Study

Hyde, Zoë, Norman, Paul E., Flicker, Leon, Hankey, Graeme J., Almeida, Osvaldo P., McCaul, Kieran A., Chubb, S. A. Paul, Yeap, Bu B.·2012·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2011-1617
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Abstract

CONTEXT: Low testosterone is associated with all-cause mortality, but the relationship with cause-specific mortality is uncertain. OBJECTIVE: Our objective was to explore associations between testosterone and its related hormones and cause-specific mortality. DESIGN: This was a population-based cohort study. SETTING AND PARTICIPANTS: Demographic and clinical predictors of mortality, and testosterone, SHBG, and LH were measured from 2001-2004 in 3637 community-dwelling men aged 70-88 yr (mean, 77 yr). MAIN OUTCOME MEASURE: Cause of death was obtained via electronic record linkage until December 31, 2008. RESULTS: During a mean follow-up period of 5.1 yr, there were 605 deaths. Of these, 207 [34.2%; 95% confidence interval (CI) = 30.4-38.1%] were due to cardiovascular disease (CVD), 231 to cancer (38.2%; 95% CI = 34.3-42.1%), 130 to respiratory diseases (21.5%; 95% CI = 18.2-24.8%), and 76 to other causes (12.6%; 95% CI = 9.9-15.2%). There were 39 deaths attributable to both cancer and respiratory diseases. Lower free testosterone (hazard ratio = 1.62; 95% CI = 1.20-2.19, for 100 vs. 280 pmol/liter), and higher SHBG and LH levels were associated with all-cause mortality. In cause-specific analyses, lower free testosterone (sub-hazard ratio = 1.71; 95% CI = 1.12-2.62, for 100 vs. 280 pmol/liter) and higher LH predicted CVD mortality, while higher SHBG predicted non-CVD mortality. Higher total testosterone and free testosterone levels (sub-hazard ratio = 1.96; 95% CI = 1.14-3.36, for 400 vs. 280 pmol/liter) were associated with mortality from lung cancer. CONCLUSIONS: Low testosterone predicts mortality from CVD but is not associated with death from other causes. Prevention of androgen deficiency might improve cardiovascular outcomes but is unlikely to affect longevity otherwise.

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Metadata

Authors
Hyde, Z., Norman, P. E., Flicker, L., Hankey, G. J., Almeida, O. P., McCaul, K. A., Chubb, S. A. P., & Yeap, B. B.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2012-01
Volume
97
Issue
1
Pages
179-189
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2011-1617
OpenAlex
W2094050115
Cited by
178
References
13
FWCI
14.36
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Low Free Testosterone Predicts Mortality from Cardiovascular Disease But Not Other Causes: The Health in Men Study. https://app.cochat.ai/papers/10.1210/jc.2011-1617
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Hyde, Z., Norman, P. E., Flicker, L., Hankey, G. J., Almeida, O. P., McCaul, K. A., Chubb, S. A. P., & Yeap, B. B. (2012). Low Free Testosterone Predicts Mortality from Cardiovascular Disease But Not Other Causes: The Health in Men Study. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2011-1617

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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