Metformin Inhibits Growth of Thyroid Carcinoma Cells, Suppresses Self-Renewal of Derived Cancer Stem Cells, and Potentiates the Effect of Chemotherapeutic Agents

Metformin and reduced risk of cancer in diabetic patients

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Hirsch, H. A., Iliopoulos, D., Tsichlis, P. N., & Struhl, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2994 · Cited by 1,115

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

Zakikhani, M., Dowling, R., Fantus, I. G., Sonenberg, N., & Pollak, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1500 · Cited by 1,048

Diabetes and cancer

Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0087 · Cited by 1,009

Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

Bowker, S. L., Majumdar, S. R., Veugelers, P., & Johnson, J. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1558 · Cited by 933

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

Dowling, R. J. O., Zakikhani, M., Fantus, I. G., Pollak, M., & Sonenberg, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2310 · Cited by 933

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., & Gonzalez-Angulo, A. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.19.6410 · Cited by 880 · cited 3×

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Sahra, I. B., Laurent, K., Loubat, A., Giorgetti-Peraldi, S., Colosetti, P., Auberger, P., Tanti, J. F., Le Marchand-Brustel, Y., & Bost, F. (2008) · Oncogene · doi:10.1038/sj.onc.1211024 · Cited by 861

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes

Landman, G. W. D., Kleefstra, N., van Hateren, K. J. J., Groenier, K. H., Gans, R. O. B., & Bilo, H. J. G. (2010) · Diabetes Care · doi:10.2337/dc09-1380 · Cited by 502

Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer

Nagayama, Y., & Hamada, K. (2022) · Metabolites · doi:10.3390/metabo12121214 · Cited by 26

Synergistic anticancer effects of doxorubicin and metformin combination therapy: A systematic review

Jalali, F., Fakhari, F., Sepehr, A., Zafari, J., Sarajar, B. O., Sarihi, P., & Jafarzadeh, E. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.101946 · Cited by 24

TMP21 modulates cell growth in papillary thyroid cancer cells by inducing autophagy through activation of the AMPK/mTOR pathway.

Xu, X., Gao, H., Qin, J., He, L., & Liu, W. (2015) · PubMed Central · Cited by 24

Thyroid Hormone and Diabetes Mellitus Interplay: Making Management of Comorbid Disorders Complicated

Chauhan, A., & Patel, S. S. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2374-8756 · Cited by 27

Metformin associated with photodynamic therapy – A novel oncological direction

Nenu, I., Popescu, T., Aldea, M. D., Craciun, L., Olteanu, D. E., Tatomir, C. B., Bolfă, P., Ion, R., Mureșan, A., & Filip, G. A. (2014) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2014.04.027 · Cited by 23

Effect of IL-6 on proliferation of human thyroid anaplastic cancer stem cells.

Zheng, R., Chen, G., Li, X., Wei, X., Liu, C., & Derwahl, M. (2019) · Europe PMC (PubMed Central) · Cited by 23

Role of gut microbiota in the pathogenesis of castration-resistant prostate cancer: a comprehensive study using sequencing and animal models

Lin, G.-W., Zhang, F., Weng, X., Hong, Z., Ye, D., & Wang, G. (2024) · Oncogene · doi:10.1038/s41388-024-03073-6 · Cited by 22

Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy

Padinharayil, H., Rai, V., & George, A. (2023) · Cancers · doi:10.3390/cancers15041070 · Cited by 26

The effect of metformin on the hypothalamic-pituitary-thyroid axis in patients with type 2 diabetes and amiodarone-induced hypothyroidism

Krysiak, R. G., Gilowska, M., Szkróbka, W., & Okopień, B. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.11.010 · Cited by 23

Thyroid Abnormalities in Patients With Extreme Insulin Resistance Syndromes

Kushchayeva, Y. S., Kushchayev, S. V., Startzell, M. S., Cochran, E. K., Auh, S., Dai, Y., Lightbourne, M., Skarulis, M. C., & Brown, R. J. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02289 · Cited by 22

Insulin resistance is another factor that increases the risk of recurrence in patients with thyroid cancer

Pitoia, F., Abelleira, E., Bueno, F., Urciuoli, C., Schmidt, A., & Nièpomniszcze, H. (2014) · Endocrine · doi:10.1007/s12020-014-0416-6 · Cited by 20

Targeting Cancer Stem Cells with Defined Compounds and Drugs

Naujokat, C., & Laufer, S. (2013) · Journal of cancer research updates · Cited by 19

Effect of type 2 diabetes and antihyperglycemic drug therapy on signs of tumor invasion in papillary thyroid cancer

Li, C., Kuang, J., Zhao, Y., Sun, H., & Guan, H. (2020) · Endocrine · doi:10.1007/s12020-020-02291-8 · Cited by 19

Efficacy of Metformin for Benign Thyroid Nodules in Subjects With Insulin Resistance: A Systematic Review and Meta-Analysis

Sui, M., Yu, Y., Zhang, H., Di, H., Liu, C., & Fan, Y. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00494 · Cited by 21

The development and benefits of metformin in various diseases

Dong, Y., Qi, Y., Jiang, H., Tian, M., Zhang, Y., Peng, C. S., Li, W.-C., Zhang, Y., Zhou, Y., Zang, Y., et al. (2023) · Frontiers of Medicine · doi:10.1007/s11684-023-0998-6 · Cited by 21

Repositioning therapy for thyroid cancer: new insights on established medications

Kushchayeva, Y. S., Jensen, K. E., Burman, K. D., & Vasko, V. V. (2014) · Endocrine Related Cancer · doi:10.1530/erc-13-0473 · Cited by 18

Therapeutic potential of the metabolic modulator Metformin on osteosarcoma cancer stem-like cells

Paiva‐Oliveira, D. I., Martins‐Neves, S. R., Abrunhosa, A., Ribeiro, C., & Gomes, C. M. F. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3467-6 · Cited by 18

Metformin Reduces Thyroid Cancer Tumor Growth in the Metastatic Niche of Bone by Inhibiting Osteoblastic RANKL Productions

Shin, H. S., Sun, H. J., Whang, Y. M., Park, Y. J., Park, D. J., & Cho, S. W. (2020) · Thyroid · doi:10.1089/thy.2019.0851 · Cited by 20

Metformin Potentiates the Effects of Anlotinib in NSCLC via AMPK/mTOR and ROS-Mediated Signaling Pathways

Zhu, Z., Jiang, T., Suo, H., Xu, S., Zhang, C., Ying, G., & Zhao, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.712181 · Cited by 18

Lactic Acidosis in Patients with Solid Cancer

Heneberg, P. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0267 · Cited by 17

Impact of metformin on disease control and survival in patients with head and neck cancer: A retrospective cohort study

Lee, D. J., McMullen, C. P., Foreman, A., Huang, S. H., Lu, L., Xu, W., de Almeida, J. R., Liu, G., Bratman, S. V., & Goldstein, D. P. (2019) · Journal of Otolaryngology - Head and Neck Surgery · doi:10.1186/s40463-019-0348-5 · Cited by 18

Activation of AMPK promotes thyroid cancer cell migration through its interaction with PKM2 and β-catenin

Chen, J., Zhou, Q., Feng, J., Zheng, W., Du, J., Meng, X., Wang, Y., & Wang, J. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116877 · Cited by 17

Perspectives of the AMP-activated kinase (AMPK) signalling pathway in thyroid cancer

de Andrade, B. M., & de Carvalho, D. P. (2014) · Bioscience Reports · doi:10.1042/bsr20130134 · Cited by 17

Effects of Metformin Combined With Antifolates on HepG2 Cell Metabolism and Cellular Proliferation

Tawfik, S. M., Abdollah, M. R. A., Elmazar, M. M., El‐Fawal, H. A. N., & Abdelnaser, A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.828988 · Cited by 16

Impaired Glucose Metabolism, Anti-Diabetes Medications, and Risk of Thyroid Cancer

Kushchayeva, Y. S., Kushchayev, S. V., Jensen, K. E., & Brown, R. J. (2022) · Cancers · doi:10.3390/cancers14030555 · Cited by 19

The anti-cancer effects of phenformin in thyroid cancer cell lines and in normal thyrocytes

Coperchini, F., Croce, L., Denegri, M., Awwad, O., Ngnitejeu, S. T., Magri, F., Chiovato, L., & Rotondi, M. (2019) · Oncotarget · doi:10.18632/oncotarget.27266 · Cited by 15

Metformin exerts an antitumoral effect on papillary thyroid cancer cells through altered cell energy metabolism and sensitized by BACH1 depletion

Yu, Y., Feng, C., Kuang, J., Guo, L., & Guan, H. (2022) · Endocrine · doi:10.1007/s12020-021-02977-7 · Cited by 14

Integration of metabolomics and transcriptomics reveals metformin suppresses thyroid cancer progression via inhibiting glycolysis and restraining DNA replication

Ouyang, J., Feng, Y., Zhang, Y., Liu, Y., Li, S., Wang, J., Tan, L., & Zou, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115659 · Cited by 14

Effects of Metformin on TSH Levels and Benign Nodular Goiter Volume in Patients Without Insulin Resistance or Iodine Insufficiency

dos Santos, P. B., Gertrudes, L. N., Conceição, F. L., de Andrade, B. M., de Carvalho, D. P., Vaisman, M., & Teixeira, P. D. F. D. S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00465 · Cited by 14

The impact of combination therapy with metformin and exogenous vitamin D on hypothalamic‐pituitary‐thyroid axis activity in women with autoimmune thyroiditis and high‐normal thyrotropin levels

Krysiak, R. G., Kowalcze, K. E., & Okopień, B. (2020) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13233 · Cited by 14

Canagliflozin reduces thyroid cancer cells migration in vitro by inhibiting CXCL8 and CCL2: An additional anti-tumor effect of the drug

Coperchini, F., Greco, A., Croce, L., Pignatti, P., Muzza, M., Petrosino, E., Teliti, M., Magri, F., & Rotondi, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115974 · Cited by 13

Synergistic cytotoxicity of the dipeptidyl peptidase-IV inhibitor gemigliptin with metformin in thyroid carcinoma cells

Kim, S. H., Kang, J. G., Kim, C. S., Ihm, S., Choi, M. G., Yoo, H. J., & Lee, S. J. (2017) · Endocrine · doi:10.1007/s12020-017-1503-2 · Cited by 13

Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells

Wang, K., Wang, S., Chen, K., Zhao, Y., Ma, X., & Wang, L. (2018) · Journal of Nanomaterials · doi:10.1155/2018/2603712 · Cited by 13

An analysis of the relative risk for goitre in euthyroid patients with type 2 diabetes

Díez, J. J., & Iglesias, P. (2013) · Clinical Endocrinology · doi:10.1111/cen.12169 · Cited by 13

Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs

Greco, A., Coperchini, F., Croce, L., Magri, F., Teliti, M., & Rotondi, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1303844 · Cited by 13

Metformin, but not sitagliptin, enhances WP 631-induced apoptotic HepG2 cell death

Śliwińska, A., Rogalska, A., Marczak, A., Kasznicki, J., & Drzewoski, J. (2015) · Toxicology in Vitro · doi:10.1016/j.tiv.2015.04.019 · Cited by 12

Diabetes and Cancer: Epidemiological, Clinical, and Experimental Perspectives

Tseng, C., Chen, C., & Landolph, J. R. (2012) · Experimental Diabetes Research · doi:10.1155/2012/101802 · Cited by 13

Effect of Interferon-γon the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation

Rotondi, M., Coperchini, F., Awwad, O., Pignatti, P., Buduo, C. A. D., Abbonante, V., Magri, F., Balduini, A., & Chiovato, L. (2016) · Mediators of Inflammation · doi:10.1155/2016/8512417 · Cited by 11

Exploring non-covalent interactions for metformin-thyroid hormones stabilization: Structure, Hirshfeld atomic charges and solvent effect

Altalhi, T., Ibrahim, M. M., Gobouri, A. A., & El‐Sheshtawy, H. S. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.113590 · Cited by 11

Metformin mitigates radiation toxicity exerting antioxidant and genoprotective properties

Карманова, Е. Е., Черников, А. В., Popova, N. R., Sharapov, M. G., Иванов, В. Е., & Брусков, В. И. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02466-w · Cited by 12

Combination of mTOR inhibitor PP242 and AMPK activator metformin exerts enhanced inhibitory effects on colorectal carcinoma cells in vitro by blocking multiple kinase pathways

Sun, C., Yang, X., Jin, Z., & Gao, Z. (2022) · Journal of Chemotherapy · doi:10.1080/1120009x.2022.2091122 · Cited by 10

Will metformin use lead to a decreased risk of thyroid cancer? A systematic review and meta-analyses

Li, H., Chen, Y., Hu, L., Yang, W., Gao, Z., Liu, M., Tao, H., & Li, J. (2023) · European Journal of Medical Research · doi:10.1186/s40001-023-01287-0 · Cited by 10

Metformin inhibits the activation of melanocortin receptors 2 and 3 in vitro: A possible mechanism for its anti-androgenic and weight balancing effects in vivo?

Parween, S., Rihs, S., & Flück, C. E. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105684 · Cited by 10

Metformin as a promising therapeutic agent for papillary thyroid cancer: Mechanisms of antitumor and pro-apoptotic activity

Wincenciuk, K., Buczyńska, A., Kretowski, A. J., & Adamska, A. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102483 · Cited by 9

Side population cells in anaplastic thyroid cancer and normal thyroid

Mahkamova, K., Latar, N. H. M., Aspinall, S. R., & Meeson, A. P. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.11.012 · Cited by 9

Effects of Slow-Acting Metformin Treatment on the Hormonal and Morphological Thyroid Profile in Patients with Insulin Resistance

Condorelli, R. A., Cannarella, R., Aversa, A., Basile, L., Avola, O., Calogero, A. E., & Vignera, S. L. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14101987 · Cited by 10

Gemigliptin, a novel dipeptidyl peptidase-IV inhibitor, exerts a synergistic cytotoxicity with the histone deacetylase inhibitor PXD101 in thyroid carcinoma cells

Kim, S. H., Kang, J. G., Kim, C. S., Ihm, S., Choi, M. G., Yoo, H. J., & Lee, S. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0792-x · Cited by 9

Metastatic Anaplastic Thyroid Carcinoma in Complete Remission: Morphological, Molecular, and Clinical Work-Up of a Rare Case

Stenman, A., Hellgren, L. S., Jatta, K., Hysek, M. H., Zemmler, M., Altena, R., Nilsson, I., Bränström, R., Zedenius, J., & Juhlin, C. C. (2020) · Endocrine Pathology · doi:10.1007/s12022-020-09606-5 · Cited by 9

Metformin Enhances Anti-proliferative Effect of Cisplatin in Cervical Cancer Cell Line

Yudhani, R. D., Pesik, R. N., & Indarto, D. (2016) · Indonesian Journal of Clinical Pharmacy · doi:10.15416/ijcp.2016.5.2.75 · Cited by 8

Metformin selectively targets 4T1 tumorspheres and enhances the antitumor effects of doxorubicin by downregulating the AKT and STAT3 signaling pathways

Kwon, Y., Chun, S., Nan, H., Nam, K., Lee, C., & Kim, S. Y. (2018) · Oncology Letters · doi:10.3892/ol.2018.9827 · Cited by 7

The public health burden of diabetes mellitus and thyroid disease: twin epidemics

Razvi, S. (2026) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01226-5 · Cited by 8

The effect of Metformin treatment in obese insulin-resistant patients with euthyroid goiter

Răcătăianu, N., Bolboaca, S. D., Sitar-Tăut, A., Mârza, S., Moga, D. C., Valea, A., & Ghervan, C. (2018) · Acta Clinica Belgica · doi:10.1080/17843286.2018.1439273 · Cited by 7

circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood–brain barrier integrity and cognitive function in uremic encephalopathy

Liu, Y., Qin, Y., & Zhang, Y. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09865-6 · Cited by 6

Effects of nuclear factor‑κB on the uptake of 131iodine and apoptosis of thyroid carcinoma cells

Chen, F., Yin, S.-T., Zhu, J., Li, J., Zhang, H., Yang, C., Liu, C., & Deng, Z. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8481 · Cited by 6

Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study

Evran, M., Pire, G., & Güney, İ. B. (2024) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/0118715303307313240315162000 · Cited by 5

Effect of metformin alone and in combination with etoposide and epirubicin on proliferation, apoptosis, necrosis, and migration of B-CPAP and SW cells as thyroid cancer cell lines

Ghavami, G., Kiasari, R. E., Pakzad, F., & Sardari, S. (2023) · Research in Pharmaceutical Sciences · doi:10.4103/1735-5362.367797 · Cited by 5

Metformin: Midlife maturity, maiden charm

Kalra, S., Dhamija, P., & Das, A. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.103028 · Cited by 5

Ability of metformin to deplete NAD+ contributes to cancer cell susceptibility to metformin cytotoxicity and is dependent on NAMPT expression

Zhuang, Y., Haugrud, A. B., Schaefer, M. A., Messerli, S. M., & Miskimins, W. K. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1225220 · Cited by 4

A novel exploration of COL11A1's role in regulating myeloid-derived suppressor cell activation within the colon cancer microenvironment

Niu, W., Du, X., Song, Y., Guo, L., Liu, B., & Tong, X. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.101181 · Cited by 4

Tumor-suppressive role of miR-139-5p in angiogenesis and tumorigenesis of ovarian cancer: Based on GEO microarray analysis and experimental validation

Tan, S., Chen, X., & Liu, W. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110730 · Cited by 4

Biological Anti-Tumoral Mechanisms of Metformin in Head and Neck Squamous Cell Carcinomas: A Systematic Review

Buset, T., Yanni, A., Gerbaux, M., Bouland, C., Eynden, X. V., Javadian, R., Lechien, J. R., Loeb, I., Boutremans, E., Saussez, S., et al. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14207258 · Cited by 3

The Role of Inositols in Endocrine and Neuroendocrine Tumors

Mormando, M., Puliani, G., Bianchini, M., Lauretta, R., & Appetecchia, M. (2024) · Biomolecules · doi:10.3390/biom14081004 · Cited by 3

Metformin and the thyroid: An unexplored therapeutic option

Unnikrishnan, A., Kalra, S., & Dhamija, P. (2012) · Thyroid Research and Practice · doi:10.4103/0973-0354.99642 · Cited by 3

Insulin resistance is associated with larger thyroid volume in adults with type 1 diabetes independently from presence of thyroid autoimmunity

Rogowicz‐Frontczak, A., Piłaciński, S., Chwialkowska, A. T., Naskręt, D., & Zozulińska‐Ziółkiewicz, D. (2018) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2018.1455221 · Cited by 3

Antineoplastic Activity of an Old Natural Antidiabetic Biguanide on the Human Thyroid Carcinoma Cell Line

Nozhat, Z., Zarkesh, M., Baldini, E., Mohammadi‐Yeganeh, S., Azizi, F., & Hedayati, M. (2021) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520621666210118093532 · Cited by 3

Metformin Decreases Serum Thyroglobulin Concentration in Nonmedullary Thyroid Carcinoma

Caetano, C. M., Pico, P. T., Singh, C., Tendler, B. E., Malchoff, D. M., & Malchoff, C. D. (2022) · Journal of the Endocrine Society · doi:10.1210/jendso/bvac140 · Cited by 2

The Comparative Effect of Combination of Metformin and Megestrol Acetate With Megestrol Acetate Alone on Endometrial Growth Disorders

Sayyah-Melli, M., Pourazad, S., Gharabaghi, P. M., Ouladsahebmadarek, E., Jafari-Shobeiri, M., & Rahmani, V. (2017) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2018.35 · Cited by 2

THERAPEUTIC USE OF METFORMIN IN THYROID CANCER

Fathi, F. H., Almulathanon, A. A. Y., & Mohammad, J. A. (2022) · Military Medical Science Letters · doi:10.31482/mmsl.2022.020 · Cited by 2

Community awareness of hereditary blood diseases and the benefit of premarital screening program in Saudi Arabia

Elhefny, M., Alessa, A., Alzahrani, S., Almarhabi, Y. A., Almaedy, B., Alshaikhi, O. A., Alessa, H., Alghamdi, H., Alamri, A., & Alghamdi, T. H. (2022) · Medical Science · doi:10.54905/disssi/v26i128/ms424e2505 · Cited by 1

Câncer de tireoide no Brasil: um estudo descritivo dos casos informados entre 2013-2020

Rezende, R. B. (2023) · Research Society and Development · doi:10.33448/rsd-v12i2.39974 · Cited by 1

Repurposing Metformin: Potential as a Prevention, Treatment and Adjunct Therapy in Pancreatic Cancer

Kamizela, E., Rudzińska, A., Ponikowski, K., Wrzosek, K., Gumółka, P., Oberda, J., Paluch, A., Haba, S., Jakubik, K., Kolasa, E., et al. (2024) · Quality in Sport · doi:10.12775/qs.2024.36.56451 · Cited by 1

Impact of Incretin Mimetics on Thyroid Cancer Among Patients with Type 2 Diabetes: A Retrospective Cohort Time-to-Event Analysis

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Thyroglobulin Test at 3 Weeks after Surgery in Well-Differentiated Thyroid Cancer and its Predictive Value: The Role of Endocrine–Metabolic Status

Berstein, L. M., Vasilyev, D. A., Раджабова, З. А., & Евгеньевна, П. Т. (2014) · International Journal of Endocrine Oncology · doi:10.2217/ije.14.27 · Cited by 1

Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus

Shpakov, A. O. (2017) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20176303219 · Cited by 1

The use of metformin in the treatment of gastrointestinal cancer

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Inositols as adjuvant treatments in oncology

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Anti-tumor effect of metformin in oncological patients: a systematic review

de Oliveira, R. K., Prieto, G. B., da Silva, V. R. O., Bavaresco, P. S., Alves, N. P., de Queiroz, D. A., & de Queiroz, E. A. I. F. (2024) · Scientific Electronic Archives · doi:10.36560/18120252025 · Cited by 1

Pharmacological interventions part IV: Metabolic modifiers

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Thyroid Cancer Stem Cells – Strategies for Therapeutic Targeting

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New Perspectives on Diagnostics, Prognosis, and Therapy in Aggressive Endocrine Tumours

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Efficacy of metformin in the treatment of abdominal obesity patients without diabetes

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Effect of Metformin on Serum Thyrotropin (Thyroid Stimulating Hormone) Levels in Hypothyroid Patients on Stable and Adequate Levothyroxine Doses with Diabetes or Pre- Diabetes

Sinha, A. (2016) · Journal of Endocrinology and Diabetes · doi:10.15226/2374-6890/3/6/00166

Плейотропные эффекты метформина: антионкогенное действие (обзор литературы)

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Effect of metformin on thyroid function tests in type 2 diabetic patients

Abed, M. N. (2019) · Al-Mağallaẗ al-ʻirāqiyyaẗ li-l-ṣaydalaẗ · doi:10.33899/iphr.2019.0161194

Exertional anterior compartment syndrome with fascial hernias.

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STUDY OF VITAMIN D STATUS IN TYPE II DIABETES MELLITUS PATIENTS AND ITS CORRELATION TO THYROID FUNCTION: A CROSS SECTIONAL STUDY IN A TERTIARY HEALTH CARE CENTRE IN TRIPURA

Debbarma, A., Deb, P., & Roy, S. K. (2021) · Indian Journal Of Applied Research · doi:10.36106/8910619

High luteinizing hormone levels are associated with Thyroid Nodules in Male Patients with Type 2 DiabetesPreprint

Zheng, R., Zhang, H., Cao, L., Ding, W., Wang, Y., & Liu, C. (2020) · doi:10.21203/rs.3.rs-32703/v1

Pharmacological approaches for correction of thyroid dysfunctions in diabetes mellitus

Shpakov, A. O. (2017) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750817040059

Effect of metformin on gene expression of multidrug resistance associated protein 2 (mrp2) in mcf-7 cells

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Investigating the Combinational Effect of Micellar Curcumin and Metformin on the Invasion of PC3 Prostate Cancer Cell Line

Ghahari, N., Abkhiz, S., Montazeri, H., & Tarighi, P. (2023) · Tabari Biomedical Student Research Journal · doi:10.32598/tbsrj.v5i3.10537

Type 2 diabetes mellitus and thyroid dysfunction, revisiting the intersections: A review article

Ezeani, I. U., & Ogbonna, S. U. (2022) · African Journal of Endocrinology and Metabolism · doi:10.4103/ajem.ajem_13_22

OBESITY AS A MODIFIABLE DETERMINANT OF THYROID DYSFUNCTION, STRUCTURAL CHANGES, AND THYROID CANCER

Baran, K., Grygorowicz, A., Ględa, M., Szyszka, M., Radecka, W., Kozak, W., Szreiber, A., Grela, K., Nowacka, K., Jabłoński, K., et al. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4647

Metabolic crosstalk between differentiated thyroid cancer and cardiovascular disease: insulin resistance as a molecular bridge—a proposed mechanism

Hou, G., & Gao, T. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1795263

Development of metformin-encapsulated poly(lactic-co-glycolic acid)-polyethylene glycol nanoparticles

İtil, E., Surer, S. I., Hızlıateş̨, C. G., & Oktay, G. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12042-z

Comparison of Metformin Combinations with Other Repurposed Drugs in the Treatment of Hamster Fibrosarcoma: A Review

Popović, D. J., Popović, K. J., Miljković, D., Poša, M., Dolicanin, Z. C., Čapo, I., & Popović, J. K. (2026) · Pharmaceuticals · doi:10.3390/ph19081254

Translational Highlights from The Journal of Clinical Endocrinology & Metabolism

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Effect of metformin on growth of differentiated thyroid cells and thyroid\ncarcinoma cells and their derived cancer stem cells

Chen, G. (2012) · Refubium (Universitätsbibliothek der Freien Universität Berlin)

Effect of metformin on growth of differentiated thyroid cells and thyroid carcinoma cells and their derived cancer stem cells

Chen, G. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17583

La metformina inhibe el crecimiento de células de carcinoma de tiroides, suprime la autorrenovación de las células madre del cáncer y potencia el efecto de los agentes quimioterapéuticos

González, D. C. F. (2012) · Revista de Endocrinología y Nutrición

Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

García-Sáenz, M. R., Lobaton-Ginsberg, M., & Ferreira‐Hermosillo, A. (2022) · Biomolecules · doi:10.3390/biom12040574 · Cited by 32