Metformin Inhibits Growth of Thyroid Carcinoma Cells, Suppresses Self-Renewal of Derived Cancer Stem Cells, and Potentiates the Effect of Chemotherapeutic Agents

Metformin and reduced risk of cancer in diabetic patients

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

Hirsch, H. A., Iliopoulos, D., Tsichlis, P. N., & Struhl, K. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2994 · Cited by 1,115

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

Zakikhani, M., Dowling, R., Fantus, I. G., Sonenberg, N., & Pollak, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1500 · Cited by 1,048

Diabetes and cancer

Vigneri, P., Frasca, F., Sciacca, L., Pandini, G., & Vigneri, R. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0087 · Cited by 1,009

Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

Bowker, S. L., Majumdar, S. R., Veugelers, P., & Johnson, J. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1558 · Cited by 933

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

Dowling, R. J. O., Zakikhani, M., Fantus, I. G., Pollak, M., & Sonenberg, N. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2310 · Cited by 933

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., & Gonzalez-Angulo, A. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.19.6410 · Cited by 880 · cited 3×

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Sahra, I. B., Laurent, K., Loubat, A., Giorgetti-Peraldi, S., Colosetti, P., Auberger, P., Tanti, J. F., Le Marchand-Brustel, Y., & Bost, F. (2008) · Oncogene · doi:10.1038/sj.onc.1211024 · Cited by 861

Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes

Landman, G. W. D., Kleefstra, N., van Hateren, K. J. J., Groenier, K. H., Gans, R. O. B., & Bilo, H. J. G. (2010) · Diabetes Care · doi:10.2337/dc09-1380 · Cited by 502

Cancer metabolism: a therapeutic perspective

Martinez-Outschoorn, U. E., Peiris-Pagés, M., Pestell, R. G., Sotgia, F., & Lisanti, M. P. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.60 · Cited by 1,505

Metformin—mode of action and clinical implications for diabetes and cancer

Pernicova, I., & Korbonits, M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.256 · Cited by 1,393

Thyroid dysfunction and diabetes mellitus: two closely associated disorders

Biondi, B., Kahaly, G. J., & Robertson, R. P. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00163 · Cited by 598

Drug repurposing for cancer therapy

Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443

The relationship between type 2 diabetes mellitus and related thyroid diseases

Wang, C. (2013) · Journal of Diabetes Research · doi:10.1155/2013/390534 · Cited by 273

Metformin Sensitizes EGFR-TKI–Resistant Human Lung Cancer Cells In Vitro and In Vivo through Inhibition of IL-6 Signaling and EMT Reversal

Li, L., Han, R., Xiao, H., Lin, C., Wang, Y., Liu, H., Li, K., Chen, H., Sun, F., Yang, Z., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2613 · Cited by 240

Sphere-Formation Assay: Three-Dimensional in vitro Culturing of Prostate Cancer Stem/Progenitor Sphere-Forming Cells

Bahmad, H. F., Cheaito, K. A., Chalhoub, R., Hadadeh, O., Monzer, A., Ballout, F., Hajj, A. E., Mukherji, D., Liu, Y., Daoud, G., et al. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00347 · Cited by 209

Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing

Hua, Y., Zheng, Y., Yao, Y., Jia, R., Ge, S., & Zhuang, A. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04263-8 · Cited by 220

Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials

Stevens, R. J., Ali, R., Bankhead, C. R., Bethel, M. A., Cairns, B. J., Camisasca, R. P., Crowe, F. L., Farmer, A. J., Harrison, S., Hirst, J. A., et al. (2012) · Diabetologia · doi:10.1007/s00125-012-2653-7 · Cited by 161

Metformin selectively affects human glioblastoma tumor-initiating cell viability

Würth, R., Pattarozzi, A., Gatti, M., Bajetto, A., Corsaro, A., Parodi, A., Sirito, R., Massollo, M., Marini, C., Zona, G., et al. (2012) · Cell Cycle · doi:10.4161/cc.23050 · Cited by 176

Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells

Saini, N., & Yang, X. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx106 · Cited by 180

The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model

Mao‐Ying, Q., Kavelaars, A., Krukowski, K., Huo, X., Zhou, W., Price, T. J., Cleeland, C. S., & Heijnen, C. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100701 · Cited by 174

The Links Between Insulin Resistance, Diabetes, and Cancer

Orgel, E., & Mittelman, S. D. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0356-6 · Cited by 168

Links between Thyroid Disorders and Glucose Homeostasis

Eom, Y. S., Wilson, J. R., & Bernet, V. J. (2022) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2022.0013 · Cited by 182

Beyond symptomatic relief for chemotherapy‐induced peripheral neuropathy: Targeting the source

Ma, J., Kavelaars, A., Dougherty, P. M., & Heijnen, C. J. (2018) · Cancer · doi:10.1002/cncr.31248 · Cited by 154

Metformin is synthetically lethal with glucose withdrawal in cancer cells

Menéndez, J. A., Oliveras‐Ferraros, C., Cufí, S., Corominas-Faja, B., Joven, J., Martı́n-Castillo, B., & Vázquez‐Martín, A. (2012) · Cell Cycle · doi:10.4161/cc.20948 · Cited by 134

Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current

Gritti, M., Würth, R., Angelini, M., Barbieri, F., Peretti, M., Pizzi, E., Pattarozzi, A., Carra, E., Sirito, R., Daga, A., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2617 · Cited by 126

Combination of metformin with chemotherapeutic drugs via different molecular mechanisms

Peng, M., Darko, K. O., Tao, T., Huang, Y., Su, Q., He, C., Yin, T., Liu, Z., & Yang, X. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.01.005 · Cited by 111

The association between thyroid cancer and insulin resistance, metabolic syndrome and its components: A systematic review and meta-analysis

Yin, D., He, H., Yu, K., Xie, J., Lei, M., Ma, R., Li, H., Wang, Y., & Liu, Z. (2018) · International Journal of Surgery · doi:10.1016/j.ijsu.2018.07.013 · Cited by 110

Targeting LKB1 signaling in cancer

Korsse, S. E., Peppelenbosch, M. P., & van Veelen, W. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.12.006 · Cited by 107

Insulin Resistance: The Increased Risk of Cancers

Szablewski, L. (2024) · Current Oncology · doi:10.3390/curroncol31020075 · Cited by 123

Treatment With Metformin Is Associated With Higher Remission Rate in Diabetic Patients With Thyroid Cancer

Kłubo-Gwieździńska, J., Costello, J. M., Patel, A. D., Bauer, A. J., Jensen, K. E., Mete, M., Burman, K. D., Wartofsky, L., & Vasko, V. V. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3799 · Cited by 106

Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

Yang, J., Wei, J., Wu, Y., Wang, Z., Guo, Y., Lee, P. J., & Li, X. (2015) · Oncogenesis · doi:10.1038/oncsis.2015.18 · Cited by 101

Metformin inhibits thyroid cancer cell growth, migration, and EMT through the mTOR pathway

Han, B., Cui, H., Kang, L., Zhang, X., Jin, Z., Lu, L., & Fan, Z. (2015) · Tumor Biology · doi:10.1007/s13277-015-3315-4 · Cited by 100

Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells

Kłubo-Gwieździńska, J., Jensen, K. E., Costello, J. M., Patel, A. D., Hoperia, V., Bauer, A. J., Burman, K. D., Wartofsky, L., & Vasko, V. V. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0046 · Cited by 92

Role of Chemokines in Thyroid Cancer Microenvironment: Is CXCL8 the Main Player?

Rotondi, M., Coperchini, F., Latrofa, F., & Chiovato, L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00314 · Cited by 77

Mini-Special Issue paper Management of diabetic patients with hypoglycemic agents Metformin and its clinical use: new insights for an old drug in clinical practice

Cicero, A. F. G., Tartagni, E., & Ertek, S. (2012) · Archives of Medical Science · doi:10.5114/aoms.2012.31622 · Cited by 83

Oestrogen action on thyroid progenitor cells: relevant for the pathogenesis of thyroid nodules?

Xu, S., Chen, G., Peng, W. H., Renko, K., & Derwahl, M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0029 · Cited by 82

Metformin: The hidden chronicles of a magic drug

Mahmood, K., Naeem, M., & Rahimnajjad, N. A. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.10.011 · Cited by 80

Effect of metabolic syndrome and its components on recurrence and survival in colon cancer patients

Yang, Y., Mauldin, P. D., Ebeling, M. D., Hulsey, T. C., Liu, B., Thomas, M. B., Camp, E. R., & Esnaola, N. F. (2012) · Cancer · doi:10.1002/cncr.27923 · Cited by 79

Metformin Reduces Thyroid Cancer Risk in Taiwanese Patients with Type 2 Diabetes

Tseng, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109852 · Cited by 78

Sorafenib synergizes with metformin in NSCLC through AMPK pathway activation

Groenendijk, F. H., Mellema, W. W., van der Burg, E., Schut, E., Hauptmann, M., Horlings, H. M., Willems, S. M., van den Heuvel, M. M., Jonkers, J., Smit, E. F., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29113 · Cited by 76

Diabetes mellitus and thyroid diseases

Nishi, M. (2018) · Diabetology International · doi:10.1007/s13340-018-0352-4 · Cited by 73

Cancer Stem Cells: Biological Functions and Therapeutically Targeting

Ciurea, M. E., Georgescu, A., Purcaru, Ş. O., Artene, Ş.-A., Emami, G., Boldeanu, M. V., Tache, D. E., & Dricu, A. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058169 · Cited by 71

Metformin and thyroid disease

Meng, X., Xu, S., Chen, G., Derwahl, M., & Liu, C. (2017) · Journal of Endocrinology · doi:10.1530/joe-16-0450 · Cited by 72

Diabetes and Thyroid Cancer Risk: Literature Review

Shih, S., Chiu, W., Chang, T., & Tseng, C. (2012) · Experimental Diabetes Research · doi:10.1155/2012/578285 · Cited by 67

Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma

Harada, K., Ferdous, T., Harada, T., & Ueyama, Y. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3523 · Cited by 66

Insulin Resistance: Any Role in the Changing Epidemiology of Thyroid Cancer?

Malaguarnera, R., Vella, V., Nicolosi, M. L., & Belfiore, A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00314 · Cited by 68

Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies

Mimeault, M., & Batra, S. K. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2013.08.001 · Cited by 65

Metformin inhibits proliferation and enhances chemosensitivity of intrahepatic cholangiocarcinoma cell lines

Ling, S., Feng, T., Ke, Q., FAN, N., Li, L., Li, Z., Dong, C., WANG, C., Xu, F., Li, Y., et al. (2014) · Oncology Reports · doi:10.3892/or.2014.3151 · Cited by 62

The role of an anti-diabetic drug metformin in the treatment of endocrine tumors

Thakur, S., Daley, B., & Kłubo-Gwieździńska, J. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0083 · Cited by 66

A Novel Dual AMPK Activator/mTOR Inhibitor Inhibits Thyroid Cancer Cell Growth

Plews, R. L., Yusof, A. M., Wang, C., Saji, M., Zhang, X., Chen, C., Ringel, M. D., & Phay, J. E. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1777 · Cited by 62

Association Between Worse Metabolic Control and Increased Thyroid Volume and Nodular Disease in Elderly Adults with Metabolic Syndrome

Blanc, E., Ponce, C., Brodschi, D., Nepote, A., Barreto, A., Schnitman, M., Fossati, P., Salgado, P., Cejas, C. P., Faingold, C., et al. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2014.0158 · Cited by 59

Glucose-deprivation increases thyroid cancer cells sensitivity to metformin

Bikas, A., Jensen, K. E., Patel, A. D., Costello, J. M., McDaniel, D. P., Kłubo-Gwieździńska, J., Ларін, О. С., Hoperia, V., Burman, K. D., Boyle, L., et al. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0402 · Cited by 63

In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors

Barbieri, F., Thellung, S., Ratto, A., Carra, E., Marini, V., Fucile, C., Bajetto, A., Pattarozzi, A., Würth, R., Gatti, M., et al. (2015) · BMC Cancer · doi:10.1186/s12885-015-1235-8 · Cited by 61

Activation of AMPK by metformin promotes renal cancer cell proliferation under glucose deprivation through its interaction with PKM2

Liu, M., Zhang, Z., Wang, H., Chen, X., & Jin, C. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.29689 · Cited by 57

A new appraisal of iodine refractory thyroid cancer

Vaisman, F., de Carvalho, D. P., & Vaisman, M. (2015) · Endocrine Related Cancer · doi:10.1530/erc-15-0300 · Cited by 57

Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

Xiao, Z., Sperl, B., Ullrich, A., & Knyazev, P. G. (2014) · Oncotarget · doi:10.18632/oncotarget.2657 · Cited by 55

Synergistic anti-proliferative effect of metformin and sorafenib on growth of anaplastic thyroid cancer cells and their stem cells

Chen, G., Nicula, D., Renko, K., & Derwahl, M. (2015) · Oncology Reports · doi:10.3892/or.2015.3805 · Cited by 52

Metformin as an Adjuvant Drug against Pediatric Sarcomas: Hypoxia Limits Therapeutic Effects of the Drug

Garofalo, C., Capristo, M., Manara, M. C., Mancarella, C., Landuzzi, L., Belfiore, A., Lollini, P., Picci, P., & Scotlandi, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083832 · Cited by 49

Metformin and Thyroid: An Update

Παππά, Θ., & Alevizaki, M. (2013) · European Thyroid Journal · doi:10.1159/000346248 · Cited by 51

p21cip1/waf1 Coordinates Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress

Manu, K. A., Cao, P. H. A., Chai, T. F., Casey, P. J., & Wang, M. (2019) · Cancers · doi:10.3390/cancers11081112 · Cited by 47

Therapeutic potential of metformin in papillary thyroid cancer in vitro and in vivo

Cho, S. W., Yi, K. H., Han, S. K., Sun, H. J., Kim, Y. A., Oh, B., Park, Y. J., & Park, D. J. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.05.021 · Cited by 46

1,25 dihydroxyvitamin D3 inhibits the proliferation of thyroid cancer stem-like cells via cell cycle arrest

Peng, W. H., Wang, K., Zheng, R., & Derwahl, M. (2016) · Endocrine Research · doi:10.3109/07435800.2015.1037048 · Cited by 46

Preventive effect of Metformin against N-nitrosodiethylamine-initiated hepatocellular carcinoma in rats

Afzal, M., Kazmi, I., Gupta, G., Rahman, M., Kimothi, V., & Anwar, F. (2012) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2012.05.012 · Cited by 45

The Emerging Role of Insulin Receptor Isoforms in Thyroid Cancer: Clinical Implications and New Perspectives

Vella, V., & Malaguarnera, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123814 · Cited by 45

Diabetes, Diabetes Treatment, and Risk of Thyroid Cancer

Luo, J., Phillips, L. S., Liu, S., Wactawski‐Wende, J., & Margolis, K. L. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3901 · Cited by 44

Insulinooporność w chorobach endokrynnych — sposoby terapii

Rogowicz‐Frontczak, A., Majchrzak, A., & Zozulińska‐Ziółkiewicz, D. (2017) · Endokrynologia Polska · doi:10.5603/ep.2017.0026 · Cited by 46

Protective Effect of Metformin Against Thyroid Cancer Development: A Population-Based Study in Korea

Cho, Y. Y., Kang, M. J., Kim, S. Y., Jung, J. H., Hahm, J. R., Kim, T. H., Nam, J. Y., Lee, B., Lee, Y., Chung, J. H., et al. (2018) · Thyroid · doi:10.1089/thy.2017.0550 · Cited by 44

Dual wavelength irradiation antimicrobial photodynamic therapy using indocyanine green and metformin doped with nano-curcumin as an efficient adjunctive endodontic treatment modality

Pourhajibagher, M., Plotino, G., Chiniforush, N., & Bahador, A. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.101628 · Cited by 43

Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models

Morale, M. G., Tamura, R. E., & Rubio, I. G. S. (2022) · Biomolecules · doi:10.3390/biom12030357 · Cited by 43

Expression of cancer stem cell markers and epithelial-mesenchymal transition-related factors in anaplastic thyroid carcinoma.

Jung, C. W., Han, K. H., Seol, H., Park, S., Koh, J. S., Lee, S., Kim, M. J., Choi, I. J., & Myung, J. K. (2015) · Europe PMC (PubMed Central) · Cited by 42

Repurposing metformin for the treatment of gastrointestinal cancer

Júnior, A. D. D. C., Bragagnoli, A. S. C., Costa, F. O., & Carvalheira, J. B. C. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i17.1883 · Cited by 42

Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery

Aldea, M. D., Craciun, L., Tomuleasa, C., Berindan‐Neagoe, I., Kacsó, G., Florian, I. Ş., & Crivii, C. B. (2014) · Tumor Biology · doi:10.1007/s13277-014-1676-8 · Cited by 44

Metformin Reverts the Secretion of CXCL8 Induced by TNF-α in Primary Cultures of Human Thyroid Cells: An Additional Indirect Anti-Tumor Effect of the Drug

Rotondi, M., Coperchini, F., Pignatti, P., Magri, F., & Chiovato, L. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3045 · Cited by 40

Inositol(s) in thyroid function, growth and autoimmunity

Benvenga, S., & Antonelli, A. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9370-3 · Cited by 42

Targeting pancreatic cancer stem cells for cancer therapy

Xia, J., Chen, C., Chen, Z., Miele, L., Sarkar, F. H., & Wang, Z. P. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.06.002 · Cited by 39

Mechanisms Linking Obesity and Thyroid Cancer Development and Progression in Mouse Models

Kim, W. G., & Cheng, S.-Y. (2018) · Hormones and Cancer · doi:10.1007/s12672-017-0320-7 · Cited by 39

Effects of metformin on the PI3K/AKT/FOXO1 pathway in anaplastic thyroid Cancer cell lines

Nozhat, Z., Mohammadi‐Yeganeh, S., Azizi, F., Zarkesh, M., & Hedayati, M. (2018) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-018-0208-2 · Cited by 40

Thyroid cancer stem-like cells and epithelial-mesenchymal transition in thyroid cancers

Hardin, H. A., Montemayor, C., & Lloyd, R. V. (2013) · Human Pathology · doi:10.1016/j.humpath.2013.01.009 · Cited by 38

High prevalence of papillary thyroid cancer in Korean women with insulin resistance

Bae, M. J., Kim, S. S., Kim, W. J., Yi, Y., Jeon, Y. K., Kim, B. H., Lee, B., Lee, J. C., Kim, I. J., Wang, S. G., et al. (2014) · Head & Neck · doi:10.1002/hed.23848 · Cited by 38

Impact of Metformin and Compound C on NIS Expression and Iodine Uptake In Vitro and In Vivo: A Role for CRE in AMPK Modulation of Thyroid Function

Abdulrahman, R. M., Boon, M. R., Sips, H. C. M., Guigas, B., Rensen, P. C. N., Smit, J. W. A., & Hovens, G. C. (2013) · Thyroid · doi:10.1089/thy.2013.0041 · Cited by 33

Stem Cells and Cancer Stem-Like Cells in Endocrine Tissues

Lloyd, R. V., Hardin, H. A., Montemayor, C., Rotondo, F., Syro, L. V., Horváth, É., & Kovács, K. (2013) · Endocrine Pathology · doi:10.1007/s12022-013-9235-1 · Cited by 35

The Association between Type 2 Diabetes Mellitus and Thyroid Cancer

Seo, Y., Choi, H.-C., An, A. R., Park, D. J., Park, Y. J., Lee, K. E., Park, S. K., Hwang, Y., & Cho, B. (2017) · Journal of Diabetes Research · doi:10.1155/2017/5850879 · Cited by 35

Metformin blocks progression of obesity-activated thyroid cancer in a mouse model

Park, J., Kim, W. G., Zhao, L., Enomoto, K., Willingham, M. C., & Cheng, S.-Y. (2016) · Oncotarget · doi:10.18632/oncotarget.8989 · Cited by 34

Role of Metformin in the Treatment of Patients with Thyroid Nodules and Insulin Resistance: A Systematic Review and Meta-Analysis

He, X., Wu, D., Hu, C., Xu, T., Liu, Y., Liu, C., Xu, B., & Tang, W. (2018) · Thyroid · doi:10.1089/thy.2017.0707 · Cited by 35

mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib

Hanly, E. K., Bednarczyk, R. B., Tuli, N. Y., Moscatello, A. L., Halicka, H. D., Li, J., Geliebter, J., Darżynkiewicz, Z., & Tiwari, R. K. (2015) · Oncotarget · doi:10.18632/oncotarget.4052 · Cited by 33

Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo

Shen, C., Wei, W., Qiu, Z., Song, H.-J., Zhang, X., Sun, Z., & Luo, Q. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0134 · Cited by 32

Metformin induced lactic acidosis impaired response of cancer cells towards paclitaxel and doxorubicin: Role of monocarboxylate transporter

Singh, S. V., Chaube, B., Mayengbam, S. S., Singh, A., Malvi, P., Mohammad, N., Deb, A., & Bhat, M. K. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166011 · Cited by 34

Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

García-Sáenz, M. R., Lobaton-Ginsberg, M., & Ferreira‐Hermosillo, A. (2022) · Biomolecules · doi:10.3390/biom12040574 · Cited by 32

The Insulin and IGF-I Pathway in Endocrine Glands Carcinogenesis

Malaguarnera, R., Morcavallo, A., & Belfiore, A. (2012) · Journal of Oncology · doi:10.1155/2012/635614 · Cited by 33

Metformin inhibits goitrogenous effects of type 2 diabetes

Ittermann, T., Markus, M. R. P., Schipf, S., Derwahl, M., Meisinger, C., & Völzke, H. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0101 · Cited by 32

Hypoxia Increases Thyroid Cancer Stem Cell‐Enriched Side Population

Mahkamova, K., Latar, N. H. M., Aspinall, S. R., & Meeson, A. P. (2017) · World Journal of Surgery · doi:10.1007/s00268-017-4331-x · Cited by 32

Metabolic Reprogramming in Thyroid Cancer

Ju, S. H., Song, M., Lim, J. Y., Kang, Y. E., Yi, H., & Shong, M. (2024) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1802 · Cited by 37

No evidence for a decreased risk of thyroid cancer in association with use of metformin or other antidiabetic drugs: a case-control study

Becker, C., Jick, S. S., Meier, C. R., & Bodmer, M. (2015) · BMC Cancer · doi:10.1186/s12885-015-1719-6 · Cited by 32

Combined Cancer Therapy with Non-Conventional Drugs: All Roads Lead to AMPK

Chen, S., Zhu, X., Lai, X., Xiao, T. L., Wen, A., & Zhang, J. (2014) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557514666140820104444 · Cited by 31

Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β

Bahmad, H. F., Chalhoub, R., Harati, H., Bou-Gharios, J., Assi, S., Ballout, F., Monzer, A., Msheik, H., Araji, T., Elajami, M. K., et al. (2020) · Pharmacological Reports · doi:10.1007/s43440-020-00162-7 · Cited by 33

Metformin Is Associated with a Favorable Outcome in Diabetic Patients with Cervical Lymph Node Metastasis of Differentiated Thyroid Cancer

Jang, E. K., Kim, W. G., Kwon, H., Choi, Y. M., Jeon, M. J., Kim, T. Y., Shong, Y. K., Kim, W. B., & Kim, E. Y. (2015) · European Thyroid Journal · doi:10.1159/000437365 · Cited by 31

5′-AMP-Activated Protein Kinase Regulates Papillary (TPC-1 and BCPAP) Thyroid Cancer Cell Survival, Migration, Invasion, and Epithelial-to-Mesenchymal Transition

Cazarin, J., Coelho, R. G., Hecht, F., Andrade, B. M., & de Carvalho, D. P. (2016) · Thyroid · doi:10.1089/thy.2015.0440 · Cited by 31

Concentrations of Selected Adipokines, Interleukin-6, and Vitamin D in Patients with Papillary Thyroid Carcinoma in Respect to Thyroid Cancer Stages

Warakomski, J., Romuk, E. B., Jarząb, B., Krajewska, J., & Siemińśka, L. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4921803 · Cited by 31

Emerging strategies for managing differentiated thyroid cancers refractory to radioiodine

Bulotta, S., Celano, M., Costante, G., & Russo, D. (2015) · Endocrine · doi:10.1007/s12020-015-0830-4 · Cited by 30

Sonic Hedgehog Signaling in Thyroid Cancer

Xu, X., Lu, Y., Li, Y., & Prinz, R. A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00284 · Cited by 30

Insulin resistance in cancer risk and prognosis

Jacobo-Tovar, E., Medel-Sánchez, A., Durán-Castillo, C., & Guardado‐Mendoza, R. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.06.006 · Cited by 33

Metformin Synergistically Enhances Antitumor Activity of Histone Deacetylase Inhibitor Trichostatin A Against Osteosarcoma Cell Line

Duo, J., Ma, Y., Wang, G., Han, X., & Zhang, C. (2013) · DNA and Cell Biology · doi:10.1089/dna.2012.1926 · Cited by 29

Epidemiological, Pathophysiological, and Clinical Considerations on the Interplay between Thyroid Disorders and Type 2 Diabetes Mellitus

Grigoriadis, G., Koufakis, T., & Kotsa, K. (2023) · Medicina · doi:10.3390/medicina59112013 · Cited by 33

High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

Zhao, J., Zhang, Q., Yang, Y., Yao, J., Liao, L., & Dong, J. (2021) · Aging · doi:10.18632/aging.203529 · Cited by 28

Metformin Inhibits Proliferation of Human Thyroid Cancer TPC-1 Cells by Decreasing LRP2 to Suppress the JNK Pathway

He, Y., Cao, L., Wang, L., Liu, L., Huang, Y., & Gong, X. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s227915 · Cited by 30

Effects of prolonged exposure to low dose metformin in thyroid cancer cell lines

Kheder, S., Sisley, K., Hadad, S. M., & Balasubramanian, S. P. (2017) · Journal of Cancer · doi:10.7150/jca.16584 · Cited by 28

Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers

Teh, J. T., Zhu, W., Newgard, C. B., Casey, P. J., & Wang, M. (2019) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-18-0766 · Cited by 27

Thyroid tumor-initiating cells: Increasing evidence and opportunities for anticancer therapy (Review)

Gao, Y., Li, B., Wu, X., Cui, J. R., & Han, J. (2014) · Oncology Reports · doi:10.3892/or.2014.2978 · Cited by 26

Translational Highlights from The Journal of Clinical Endocrinology & Metabolism

(2012) · Molecular Endocrinology · doi:10.1210/mend.26.3.zmg534

Effect of metformin on growth of differentiated thyroid cells and thyroid\ncarcinoma cells and their derived cancer stem cells

Chen, G. (2012) · Refubium (Universitätsbibliothek der Freien Universität Berlin)

Effect of metformin on growth of differentiated thyroid cells and thyroid carcinoma cells and their derived cancer stem cells

Chen, G. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-17583

La metformina inhibe el crecimiento de células de carcinoma de tiroides, suprime la autorrenovación de las células madre del cáncer y potencia el efecto de los agentes quimioterapéuticos

González, D. C. F. (2012) · Revista de Endocrinología y Nutrición

Metformin in Differentiated Thyroid Cancer: Molecular Pathways and Its Clinical Implications

García-Sáenz, M. R., Lobaton-Ginsberg, M., & Ferreira‐Hermosillo, A. (2022) · Biomolecules · doi:10.3390/biom12040574 · Cited by 32