Cited by 336Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentHormonal and reproductive studies

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Age-Related Changes in Thyroid Function: A Longitudinal Study of a Community-Based Cohort

Bremner, Alexandra P., Feddema, Peter, Leedman, Peter J., Brown, Suzanne J., Beilby, John P., Lim, Ee Mun, Wilson, Scott G., O'Leary, Peter C., Walsh, John P.·2012·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2011-3020

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Abstract

CONTEXT: In cross-sectional studies, serum TSH concentrations increase with age. This has not been examined longitudinally, and it is uncertain whether the TSH increase reflects healthy aging or occult thyroid failure. METHODS: We measured serum TSH, free T(4), thyroid peroxidase, and thyroglobulin antibodies in 1100 participants in the 1981 and 1994 Busselton Health Surveys and derived a reference group of 908 individuals without thyroid disease or thyroid antibodies. We examined changes in thyroid function longitudinally and, in 781 participants, explored associations with the CAPZB polymorphism rs10917469. RESULTS: At 13 yr follow-up, mean serum TSH increased from 1.49 to 1.81 mU/liter, a change in mean TSH (ΔTSH) of 0.32 mU/liter [95% confidence interval (CI) 0.27, 0.38, P < 0.001], whereas mean free T(4) concentration was unchanged (16.6 vs. 16.6 pmol/liter, P = 0.7). The TSH increase was most marked in the elderly, such that gender-adjusted ΔTSH increased by 0.08 mU/liter (95% CI 0.04, 0.11) for each decade of baseline age. People with higher baseline TSH values had proportionally smaller increases in TSH, with each additional 1.0 mU/liter of baseline TSH associated with a 0.13 mU/liter decrease (age and gender adjusted) in ΔTSH (95% CI 0.09, 0.16). The ΔTSH did not differ significantly by CAPZB genotype. CONCLUSIONS: Aging is associated with increased serum TSH concentrations, with no change in free T(4) concentrations. The largest TSH increase is in people with the lowest TSH at baseline. This suggests that the TSH increase arises from age-related alteration in the TSH set point or reduced TSH bioactivity rather than occult thyroid disease.

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Chapter 29: Male sexual dysfunction in type 2 diabetes
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“19,20 The overlapping symptoms of hypogonadism with hypothyroidism necessitate the assessment of TSH. 21,22 A prolactin level is useful to exclude primary pituitary disorders.”
Background
Chinese Medicine Supplementing Qi and Activating Blood Circulation Relieves the Progression of Diabetic Cardiomyopathy
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“The observed difference in mean TSH values maybe the effect of the disparity in the age group of recruited subjects across study, as aging has been reported to be associated with increased serum TSH concentration (23).”
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Iodine Excess Is Associated with Thyroid Dysfunction Among the Elderly
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Substitution mit Schilddrüsenhormonen im höheren Lebensalter
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“In a study investigating the relationship between age and thyroid functions, it was found that serum TSH levels increased with the increasing age; however, there are no changes in fT4 levels, and there were no age-dependent increases in thyroid diseases (24).”
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Thyroid-Stimulating Hormone
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Study of the relationship of thyroid status and frailty in older Egyptian men
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Background
L’ipotiroidismo
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Soll jede latente Hypothyreose substituiert werden
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Seguimiento de sujetos sin patología tiroidea conocida, participantes en un estudio que evaluó la frecuencia de anticuerpos antitiroideos (ATPO) positivos
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Primaarse hüpotüreoosi käsitlus
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“protsentiili puhul + 0,3 mU/l) ka kilpnäärmehaiguse puudumisel, vastab eakatel (> 70 a) eutüreoosile pisut laiem TSH-vahemik: 0,4–7,0 mU/l (26, 27).”
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Biology of Aging
Parker, D., & Heflin, M. T. (2017) · Springer eBooks · doi:10.1007/978-3-319-20317-1_3-1
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Kvachenyuk, A. M., & Кваченюк, Д. (2018) · INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) · doi:10.22141/2224-0721.14.3.2018.136425
Ipotiroidismo nel paziente anziano: quando e come trattare?
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Pattern of thyroid disorders in ENT OPD of Nobel Medical College in Eastern Nepal
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Alterations in Thyroid Function Testing with Aging
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Schilddrüsenerkrankungen in der Peri- und Postmenopause
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Non-thyroidal Hypothyroidism
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Die Schilddrüse im Alter
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Schilddrüsenerkrankungen in der Peri- und Postmenopause
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Subclinical hypothyroidism in community perspective: Treat or not to treat?
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Authors: Bremner, A. P., Feddema, P., Leedman, P. J., Brown, S. J., Beilby, J. P., Lim, E. M., Wilson, S. G., O'Leary, P. C., & Walsh, J. P.
Affiliations: The University of Western Australia (AU)
Curtin University (AU)
Corresponding author: Walsh, John P.
ORCID: Bremner, Alexandra P.
Leedman, Peter J.
Brown, Suzanne J.
Beilby, John P.
Lim, Ee Mun
Wilson, Scott G.
O'Leary, Peter C.
Walsh, John P.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2012-05
Volume: 97
Issue: 5
Pages: 1554-1562
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2011-3020
OpenAlex: W1978327859
Cited by: 336
References: 33
Citations by year: 2026: 22 · 2025: 18 · 2024: 22 · 2023: 30 · 2022: 23 · 2021: 30 · 2020: 16 · 2019: 27 · 2018: 27 · 2017: 30 · 2016: 20 · 2015: 23 · 2014: 12 · 2013: 24 · 2012: 9
FWCI: 17.46
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
eSpace (Curtin University) (submittedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: serum TSH, free thyroxine, healthy aging, thyroid peroxidase antibodies, thyroglobulin antibodies, longitudinal cohort
MeSH terms: Adult, Age Factors, Aged, Aged, 80 and over, Aging, Autoantibodies, Cross-Sectional Studies, Female, Health Surveys, Humans, Iodide Peroxidase, Longitudinal Studies, Male, Middle Aged, Thyroglobulin, Thyroid Function Tests, Thyroid Gland, Thyrotropin, Thyroxine

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Age-Related Changes in Thyroid Function: A Longitudinal Study of a Community-Based Cohort

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