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Cited by 112Hormonal Regulation and HypertensionRenin-Angiotensin System StudiesAdrenal Hormones and Disorders

The DOI matches its Crossref record; 38 of the 41 references it cites were found in a registry or an index.

Evidence of Primary Aldosteronism in a Predominantly Female Cohort of Normotensive Individuals: A Very High Odds Ratio for Progression into Arterial Hypertension

Markou, Athina, Pappa, Theodora, Kaltsas, Gregory, Gouli, Aggeliki, Mitsakis, Kostas, Tsounas, Panayiotis, Prevoli, Anastasia, Tsiavos, Vaios, Papanastasiou, Labrini, Zografos, George, Chrousos, George P., Piaditis, George P.·2013·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2012-3353
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Abstract

CONTEXT: Primary aldosteronism (PA) is an established cause of hypertension, whereas high-normal serum aldosterone levels have been linked to an increased risk for hypertension. OBJECTIVE: We aimed to define the post-fludrocortisone-dexamethasone suppression test (FDST) normal cutoff values of aldosterone and the aldosterone to renin ratio and evaluate the presence of PA in normotensive individuals. DESIGN: This study was designed as a case-control study. SETTING: The study was performed in a tertiary general hospital. PATIENTS: One hundred normotensive participants (80 females), mean age 53 years, were studied. MAIN OUTCOME MEASURES: All participants underwent baseline biochemical and hormonal evaluation, FDST, and adrenal computerized tomography. Blood pressure was assessed at baseline and after 5 years. RESULTS: Sixty-nine participants with normal adrenal computerized tomography who remained normotensive after 5 years were used as a control population to calculate the cutoff values of adequate aldosterone suppression. PA was defined as a combination of post-FDST aldosterone to renin ratio of 0.93 ng/dL · μU/mL or greater (100% sensitivity and 96% specificity) and post-FDST aldosterone of 2.96 ng/dL or greater (100% sensitivity and 61% specificity on receiver-operating characteristic analysis). Thirteen of 100 participants had PA at baseline and 11 (85%) developed hypertension, whereas only 20 of 87 without PA (23%) developed hypertension at 5 years [odds ratio (OR) 18.42, 95% confidence intervals (CI) 3.76-90.10, P < .0001]. Logistic regression analysis showed a positive relation of PA [odds ratio (OR) 16.30, confidence interval (CI) 1.78-150.30, P = .01] and a negative relation of serum potassium (OR 0.39, CI 0.19-0.79, P = .01) with the development of hypertension. CONCLUSIONS: Normotensive PA represents a clinical entity referring to normotensive individuals with PA who are at increased risk for hypertension.

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Metadata

Authors
Markou, A., Pappa, T., Kaltsas, G., Gouli, A., Mitsakis, K., Tsounas, P., Prevoli, A., Tsiavos, V., Papanastasiou, L., Zografos, G., Chrousos, G. P., & Piaditis, G. P.
Affiliations
  • Department of Endocrinology and Diabetes Center (A.M., T.P., A.G., K.M., P.T., A.P., V.T., L.P., G.P.P.), 11527 Athens, Greece
  • General Hospital of Athens G. Genimatas (GR)
  • Third Department of Surgery (G.Z.), 11527 Athens, Greece
  • National and Kapodistrian University of Athens (GR)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2013-04-01
Volume
98
Issue
4
Pages
1409-1416
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2012-3353
OpenAlex
W2007085386
Cited by
112
References
41
Citations by year
2026: 5 · 2025: 14 · 2024: 10 · 2023: 7 · 2022: 8 · 2021: 14 · 2020: 15 · 2019: 9 · 2018: 9 · 2017: 16 · 2016: 2 · 2015: 1 · 2014: 2
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
primary aldosteronism, normotensive subjects, hypertension progression, aldosterone-renin ratio, serum aldosterone, cut-off values, serum potassium, adrenal imaging, women
MeSH terms
Adult, Aged, Aldosterone, Blood Pressure, Dexamethasone, Diagnostic Techniques, Endocrine, Female, Fludrocortisone, Humans, Hyperaldosteronism, Hypertension, Male, Middle Aged, Sex Ratio, Cohort Studies, Odds Ratio, Case-Control Studies, Disease Progression

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