CoChat
Sign Up
Cited by 47Hormonal Regulation and HypertensionAdrenal and Paraganglionic TumorsRenin-Angiotensin System Studies

Clinical and biochemical characteristics of normotensive patients with primary aldosteronism: a comparison with hypertensive cases

Médeau, Virginie, Moreau, François, Trinquart, Ludovic, Clemessy, Maud, Wémeau, Jean‐Louis, Vantyghem, Marie Christine, Plouin, Pierre‐François, Reznik, Yves·2008·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2008.03213.x
Open this paper in CoChat — free account

Abstract

OBJECTIVE: It is unknown why some patients with biochemical evidence of primary aldosteronism (PA) do not develop hypertension. We aimed to compare clinical and biochemical characteristics of normotensive and hypertensive patients with PA. DESIGN AND PATIENTS: Retrospective comparison of 10 normotensive and 168 hypertensive patients with PA for office or ambulatory blood pressure, serum potassium, plasma aldosterone and renin concentrations; the aldosterone:renin ratio, and tumour size. Comparison of initial hormonal pattern and drop in blood pressure following adrenalectomy in five normotensive and nine hypertensive patients matched for age, sex and body mass index. RESULTS: The 10 normotensive patients were women and presented with hypokalemia or an adrenal mass. Age, plasma aldosterone and renin concentrations were similar in normotensive and hypertensive cases, but kalemia and body mass index were significantly lower in the normotensive patients. Mean tumour diameter was larger in the normotensive patients than in the hypertensive matched patients with an adenoma (P < 0.01). In normotensive patients, diastolic blood pressure and upright aldosterone correlated negatively with kalemia. Blood pressure was lowered similarly after adrenalectomy in five normotensive PA patients and in their matched hypertensive counterparts. Aldosterone synthase expression was detected in four out of five adrenal tumours. CONCLUSIONS: Blood pressure may be normal in patients with well-documented PA. The occurrence of hypokalemia, despite a normal blood pressure profile, suggests that protective mechanisms against hypertension are present in normotensive patients.

Integrity signals

Registry

Crossref · 10.1111/j.1365-2265.2008.03213.x

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A few publications have reported normotensive PA in AI; most of these patients demonstrated occasional hypokalemia.

    “A few publications have reported normotensive PA in AI; however, most of these patients demonstrated occasional hypokalemia (8,272-274).”

    From Adrenal incidentaloma (2020) · cites this paper as [273]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Médeau, V., Moreau, F., Trinquart, L., Clemessy, M., Wémeau, J., Vantyghem, M. C., Plouin, P., & Reznik, Y.
Affiliations
  • Centre Hospitalier Universitaire de Caen Normandie (FR)
  • Université Paris Descartes (FR)
  • Inserm (FR)
  • Centre Hospitalier Universitaire de Lille (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2008-06-28
Volume
69
Issue
1
Pages
20-28
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2008.03213.x
OpenAlex
W2069451997
Cited by
47
References
48
Citations by year
2025: 1 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2014: 4 · 2013: 4 · 2012: 4
FWCI
2.18
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Keywords
primary aldosteronism, normotension, hypertension, hypokalemia, aldosterone, renin, aldosterone-renin ratio, adrenalectomy, aldosterone synthase, adrenal adenoma, tumor size, blood pressure regulation
MeSH terms
Adrenal Gland Neoplasms, Adrenalectomy, Adult, Blood Pressure, Female, Follow-Up Studies, Humans, Hyperaldosteronism, Hypertension, Male, Middle Aged, Retrospective Studies, Steroid 11-beta-Hydroxylase, Biomarkers, Case-Control Studies, Treatment Outcome, Adrenocortical Adenoma, Cytochrome P-450 CYP11B2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review