CoChat
Sign Up
Cited by 150Thyroid Disorders and TreatmentsClinical Laboratory Practices and Quality ControlThyroid Cancer Diagnosis and Treatment

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Ethnic Differences in Maternal Thyroid Parameters during Pregnancy: The Generation R Study

Korevaar, Tim I. M., Medici, Marco, de Rijke, Yolanda B., Visser, Willy, de Muinck Keizer-Schrama, Sabine M. P. F., Jaddoe, Vincent W. V., Hofman, Albert, Ross, H. Alec, Visser, W. Edward, Hooijkaas, Herbert, Steegers, Eric A. P., Tiemeier, Henning, Bongers-Schokking, Jacoba J., Visser, Theo J., Peeters, Robin P.·2013·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2013-2005
Open this paper in CoChat — free account

Abstract

CONTEXT: Abnormal maternal thyroid function during pregnancy is associated with various complications. International guidelines advocate the use of population-based trimester-specific reference ranges for thyroid function tests. When unavailable, an upper TSH limit of 2.5 for the first trimester and 3.0 mU/L for the second and third trimesters is recommended. Although interindividual differences in thyroid function tests can partially be explained by ethnicity, data on the influence of ethnicity on TSH and free T4 reference ranges during pregnancy are sparse. DESIGN: Serum TSH, free T4, T4, and TPO-antibody levels were determined during early pregnancy in 3944 women from the Generation R study, Rotterdam, The Netherlands. RESULTS: The study population consisted of 2765 Dutch, 308 Moroccan, 421 Turkish, and 450 Surinamese women. Mean TSH levels were higher in Dutch and Turkish women than in Moroccan or Surinamese women (1.50-1.48 vs 1.29-1.33 mU/L; P < .01). Although no differences in free T4 were seen, T4 was lowest in Dutch women (142 vs 150-156 nmol/L; P < .01). Turkish women had the highest frequency of TPO-antibody positivity (9.3% vs 5.0-5.8%; P < .05) and of elevated TSH levels in the second trimester (11.0% vs 3.8-7.3%; P < .01). A comparison of disease prevalence between a population-based vs an ethnicity-specific reference range changed the diagnosis for 18% of women who were initially found to have abnormal thyroid function test results. CONCLUSIONS: We show ethnic differences in serum TSH, T4, and TPO-antibody positivity and found significant diagnostic discrepancies depending on whether population or ethnicity-specific reference ranges were used to diagnose thyroid disease.

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.2013-2005

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 51 references

Cited by

Sorted by citations

Items 101–149 of 149

Related

See all

Metadata

Authors
Korevaar, T. I. M., Medici, M., de Rijke, Y. B., Visser, W., de Muinck Keizer-Schrama, S. M. P. F., Jaddoe, V. W. V., Hofman, A., Ross, H. A., Visser, W. E., Hooijkaas, H., Steegers, E. A. P., Tiemeier, H., Bongers-Schokking, J. J., Visser, T. J., & Peeters, R. P.
Affiliations
  • Erasmus MC (NL)
  • Radboud University Nijmegen (NL)
Corresponding author
Peeters, Robin P.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2013-09
Volume
98
Issue
9
Pages
3678-3686
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2013-2005
OpenAlex
W2133831600
Cited by
150
References
51
Citations by year
2026: 4 · 2025: 3 · 2024: 2 · 2023: 37 · 2022: 17 · 2021: 9 · 2020: 7 · 2019: 13 · 2018: 10 · 2017: 17 · 2016: 9 · 2015: 8 · 2014: 11 · 2013: 2
FWCI
7.84
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • Erasmus Universiteit Rotterdam
  • Erasmus Medisch Centrum
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
maternal thyroid function, pregnancy, ethnic differences, thyroid-stimulating hormone, free thyroxine, total thyroxine, thyroid peroxidase antibodies, thyroid autoimmunity, thyroid disease diagnosis, Generation R Study
MeSH terms
Adult, Female, Humans, Iodide Peroxidase, Netherlands, Pregnancy, Pregnancy Complications, Reference Values, Thyroid Diseases, Thyroid Function Tests, Thyrotropin, Thyroxine, Triiodothyronine, Prevalence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review