Low plasma atrial natriuretic peptide: a new piece in the puzzle of polycystic ovary syndrome
Abstract
CONTEXT: It is believed that a dysfunction in adipose tissue plays an important role in the pathogenesis of polycystic ovary syndrome (PCOS). Natriuretic peptides are hormones that regulate cardiovascular and body fluid homeostasis and adipose tissue metabolism. Natriuretic peptide levels are reduced in individuals with obesity and diabetes. OBJECTIVE: This study aimed to investigate whether natriuretic peptide levels are altered in women with PCOS and whether they correlate with adiponectin levels or insulin sensitivity markers. DESIGN AND SETTING: This was a cross-sectional study at a referral center in a teaching hospital. PATIENTS OR OTHER PARTICIPANTS: We evaluated 40 patients diagnosed with PCOS according to the Rotterdam criteria and 36 control women matched for age and body mass index. MAIN OUTCOME MEASURES: We measured serum adiponectin, plasma atrial natriuretic peptide (ANP), and plasma brain natriuretic peptide using enzyme immunoassays in both groups. We evaluated metabolic markers, such as fasting glucose, insulin, total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides. In addition, we calculated the homeostasis model assessment for insulin resistance index (HOMA-IR) and the lipid accumulation product (LAP) index and tested the linear correlations between these metabolic indices and the plasma ANP and serum adiponectin concentrations. RESULTS: ANP and adiponectin were reduced in the PCOS group compared with the control group (P = 0.010 and P = 0.014, respectively). The brain natriuretic peptide concentration did not differ between the two groups (P = 0.883). There was no correlation between ANP and any of the metabolic markers. In the control group, the serum adiponectin level was inversely correlated with BMI (P = 0.011), waist circumference (P = 0.021), insulin (P = 0.013), fasting glucose (P = 0.010), homeostasis model assessment for insulin resistance index (P = 0.007), and lipid accumulation product (P = 0.022). Remarkably, none of these correlations were observed in the women with PCOS. CONCLUSION: Women with PCOS had lower ANP and adiponectin compared with controls matched for age and BMI. Thus, the mechanisms that affect ANP and adiponectin production and clearance may be altered in PCOS, regardless of adiposity. These hormones may be involved in the metabolic features of PCOS.
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Previous cross-sectional studies evaluating MR-proADM, MR-proANP and copeptin in PCOS and healthy controls have produced contradicting results.
“The three biomarkers have previously been evaluated in PCOS and healthy controls in cross-sectional studies, with contradicting results (13, 14, 15, 16, 17, 18).”
From Effect of liraglutide on atrial natriuretic peptide, adrenomedullin, and copeptin in PCOS (2018) · cites this paper as [15]
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- Authors
- Lauria, P. B. M., Del Puerto, H. L., Reis, A. M., Candido, A. L., & Reis, F. M.
- Affiliations
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Reis, Fernando M.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-12
- Volume
- 98
- Issue
- 12
- Pages
- 4882-4889
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2116291799
- Cited by
- 23
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, atrial natriuretic peptide, brain natriuretic peptide, adiponectin, adipose tissue dysfunction, insulin resistance, natriuretic peptides, lipid accumulation product, body mass index, metabolic biomarkers, PCOS pathogenesis, obesity, insulin sensitivity, dyslipidemia, fasting blood glucose, lipid profile, Rotterdam criteria
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Hospitals, Teaching, Humans, Insulin Resistance, Atrial Natriuretic Factor, Polycystic Ovary Syndrome, Biomarkers, Down-Regulation, Body Mass Index, Natriuretic Peptide, Brain, Adiposity, Overweight, Lipid Metabolism, Adiponectin
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