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Liraglutide Reduces Oxidative Stress And Restores Heme Oxygenase-1 and Ghrelin Levels in Patients with Type 2 Diabetes: A Prospective Pilot Study
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CONTEXT: Liraglutide is a glucagon-like peptide-1 analog and glucose-lowering agent whose effects on cardiovascular risk markers have not been fully elucidated. OBJECTIVE: We evaluated the effect of liraglutide on markers of oxidative stress, heme oxygenase-1 (HO-1), and plasma ghrelin levels in patients with type-2 diabetes mellitus (T2DM). DESIGN AND SETTING: A prospective pilot study of 2 months' duration has been performed at the Unit of Diabetes and Cardiovascular Prevention at University of Palermo, Italy. Patients and Intervention(s): Twenty subjects with T2DM (10 men and 10 women; mean age: 57 ± 13 y) were treated with liraglutide sc (0.6 mg/d for 2 wk, followed by 1.2 mg/d) in addition to metformin (1500 mg/d orally) for 2 months. Patients with liver disorders or renal failure were excluded. MAIN OUTCOME MEASURE(S): Plasma ghrelin concentrations, oxidative stress markers, and heat-shock proteins, including HO-1 were assessed. RESULTS: The addition of liraglutide resulted in a significant decrease in glycated hemoglobin (HbA1c) (8.5 ± 0.4 vs 7.5 ± 0.4%, P < .0001). In addition, plasma ghrelin and glutathione concentrations increased (8.2 ± 4.1 vs 13.6 ± 7.3 pg/ml, P = .0007 and 0.36 ± 0.06 vs 0.44 ± 0.07 nmol/ml, P = .0002, respectively), whereas serum lipid hydroperoxides and HO-1 decreased (0.11 ± 0.05 vs 0.04 ± 0.07 pg/ml, P = .0487 and 7.7 ± 7.7 vs 3.6 ± 1.8 pg/ml, P = .0445, respectively). These changes were not correlated with changes in fasting glycemia or HbA1c. CONCLUSIONS: In a 2-months prospective pilot study, the addition of liraglutide to metformin resulted in improvement in oxidative stress as well as plasma ghrelin and HO-1 concentrations in patients with T2DM. These findings seemed to be independent of the known effects of liraglutide on glucose metabolism.
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“In 2015, Rizzo et al. evidenced that the liraglutide treatment decreased oxidative stress and it was independent of the impact of liraglutide on glucose metabolism [125].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [125]
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Self-citation
Metadata
- Authors
- Rizzo, M., Abate, N., Chandalia, M., Rizvi, A. A., Giglio, R. V., Nikolic, D., Marino Gammazza, A., Barbagallo, I., Isenovic, E. R., Banach, M., Montalto, G., & Volti, G. L.
- Affiliations
- University of South Carolina (US)
- The University of Texas Medical Branch at Galveston (US)
- University of Palermo (IT)
- Biomedical Department of Internal Medicine and Medical Specialties (M.R., R.V.G., D.N., G.M.), University of Palermo, Palermo 90127, Italy
- Euro-Mediterranean Institute of Science and Technology (M.R., A.M.G., I.B., G.L.V.), Palermo 90139, Italy
- University of Catania (IT)
- Laboratory for Molecular Genetics and Radiobiology (E.R.I.), Vinca Institute, University of Belgrade, Belgrade 11000, Serbia
- Medical University of Lodz (PL)
- Corresponding author
- Rizvi, Ali A.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-02-01
- Volume
- 100
- Issue
- 2
- Pages
- 603-606
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC4318909
- OpenAlex
- W2132146653
- Cited by
- 113
- References
- 20
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 13 · 2018: 5 · 2017: 8 · 2016: 12 · 2015: 6
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion, other-oa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- VinaR (Institute of Nuclear Sciences "Vinča") (submittedVersion, other-oa)
- Funders
- Bristol-Myers Squibb
- University of South Carolina
- National Institutes of Health (UL1TR000071)
- School of Medicine, University of South Carolina
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- liraglutide, type 2 diabetes, oxidative stress, heme oxygenase-1, ghrelin, glucagon-like peptide-1 analogues, metformin, glutathione, lipid hydroperoxides, HbA1c, heat shock proteins, cardiovascular risk markers, glycemic control, insulin resistance, dyslipidemia
- MeSH terms
- Liraglutide, Adult, Aged, Diabetes Mellitus, Type 2, Drug Therapy, Combination, Female, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Pilot Projects, Prospective Studies, Oxidative Stress, Heme Oxygenase-1, Glucagon-Like Peptide 1, Ghrelin
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