Cited by 152Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Disease and Adiposity

GLP-1 receptor agonists and reduction of cardiometabolic risk: Potential underlying mechanisms

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Rizzo, Manfredi, Nikolic, Dragana, Patti, Angelo Maria, Mannina, Carlo, Montalto, Giuseppe, McAdams, Brooke S., Rizvi, Ali A., Cosentino, Francesco·2018·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic condition with an elevated impact on cardiovascular (CV) risk. The innovative therapeutic approaches for T2DM - incretin-based therapies (IBTs), including glucagon-like peptide 1 (GLP-1) receptor agonists, have become popular and more widely used in recent years. The available scientific data from clinical studies and clinical practice highlights their beyond glucose-lowering effects, which is achieved without any increase in hypoglycaemia. The former effects include reduction in body weight, lipids, blood pressure, inflammatory markers, oxidative stress, endothelial dysfunction, and subclinical atherosclerosis, thus reducing and potentially preventing CV events. In fact, the introduction of IBTs is one of the key moments in the history of diabetes research and treatment. Such therapeutic strategies allow customization of antidiabetic treatment to each patient's need and therefore obtain better metabolic control with reduced CV risk. The aim of the present paper is to provide a comprehensive overview of the effects of GLP-1RA on various cardiometabolic markers and overall CV risk, with particular attention on recent CV outcome studies and potential mechanisms. In particular, the effects of liraglutide on formation and progression of atherosclerotic plaque and mechanisms explaining its cardioprotective effects are highlighted.

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Authors
Rizzo, M., Nikolic, D., Patti, A. M., Mannina, C., Montalto, G., McAdams, B. S., Rizvi, A. A., & Cosentino, F.
Affiliations
  • University of South Carolina (US)
  • University of Palermo (IT)
  • Karolinska University Hospital (SE)
Corresponding author
Rizzo, Manfredi
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher
Elsevier BV
Published
2018-09
Volume
1864
Issue
9
Pages
2814-2821
ISSN
0925-4439 (ISSN-L)
OpenAlex
W2804938814
Cited by
152
References
78
Citations by year
2026: 11 · 2025: 16 · 2024: 18 · 2023: 21 · 2022: 26 · 2021: 25 · 2020: 17 · 2019: 13 · 2018: 5
FWCI
2.31
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
  • CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
GLP-1 receptor agonists, type 2 diabetes, cardiometabolic risk, cardiovascular risk reduction, incretin-based therapy, liraglutide, atherosclerosis, atherosclerotic plaque, endothelial dysfunction, oxidative stress, inflammation, blood pressure, lipids, weight loss, cardioprotection
MeSH terms
Glucagon-Like Peptide-1 Receptor, Liraglutide, Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Blood Glucose, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Glucagon-Like Peptides, Humans, Hypoglycemic Agents, Incretins, Plaque, Atherosclerotic

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