The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union
Open accessAbstract
CONTEXT: A growing body of evidence suggests that endocrine-disrupting chemicals (EDCs) contribute to female reproductive disorders. OBJECTIVE: To calculate the associated combined health care and economic costs attributable to specific EDC exposures within the European Union (EU). DESIGN: An expert panel evaluated evidence for probability of causation using the Intergovernmental Panel on Climate Change weight-of-evidence characterization. Exposure-response relationships and reference levels were evaluated, and biomarker data were organized from carefully identified studies from the peer-reviewed literature to represent European exposure and approximate burden of disease as it occurred in 2010. Cost-of-illness estimation used multiple peer-reviewed sources. SETTING, PATIENTS AND PARTICIPANTS AND INTERVENTION: Cost estimation was carried out from a societal perspective, ie, including direct costs (eg, treatment costs) and indirect costs such as productivity loss. RESULTS: The most robust EDC-related data for female reproductive disorders exist for 1) diphenyldichloroethene-attributable fibroids and 2) phthalate-attributable endometriosis in Europe. In both cases, the strength of epidemiological evidence was rated as low and the toxicological evidence as moderate, with an assigned probability of causation of 20%–39%. Across the EU, attributable cases were estimated to be 56 700 and 145 000 women, respectively, with total combined economic and health care costs potentially reaching €163 million and €1.25 billion. CONCLUSIONS: EDCs (diphenyldichloroethene and phthalates) may contribute substantially to the most common reproductive disorders in women, endometriosis and fibroids, costing nearly €1.5 billion annually. These estimates represent only EDCs for which there were sufficient epidemiologic studies and those with the highest probability of causation. These public health costs should be considered as the EU contemplates regulatory action on EDCs.
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Citations
Cites
Grading quality of evidence and strength of recommendations
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EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
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Grading quality of evidence and strength of recommendations for diagnostic tests and strategies
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Sperm Morphology, Motility, and Concentration in Fertile and Infertile Men
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“We adhered to the approach described in the accompanying overarching manuscript in evaluating strength of the epidemiological (using the World Health Organization GRADE Working Group criteria) (53, 54) and toxicological literature (using criteria consistent with that proposed in the EU roadmap for evaluating endocrine…”
MethodEffect of testosterone and estradiol in a man with aromatase deficiency
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Temporal trends in sperm count: a systematic review and meta-regression analysis
Levine, H., Jørgensen, N., Martino-Andrade, A., Mendiola, J., Weksler-Derri, D., Mindlis, I., Pinotti, R., & Swan, S. H. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx022 · Cited by 1,374
Barratt, C. L. R., Björndahl, L., De Jonge, C. J., Lamb, D. J., Osorio Martini, F., McLachlan, R., Oates, R. D., van der Poel, S., St John, B., Sigman, M., et al. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx021 · Cited by 505
Environmental factors in declining human fertility
Skakkebæk, N. E., Lindahl-Jacobsen, R., Levine, H., Andersson, A.-M., Jørgensen, N., Main, K. M., Lidegaard, Ø., Priskorn, L., Holmboe, S. A., Bräuner, E. V., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00598-8 · Cited by 389
Sex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Rickard, B. P., Rizvi, I., & Fenton, S. E. (2022) · Toxicology · doi:10.1016/j.tox.2021.153031 · Cited by 334
Metadata
- Authors
- Hunt, P. A., Sathyanarayana, S., Fowler, P. A., & Trasande, L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2016-04
- Volume
- 101
- Issue
- 4
- Pages
- 1562-1570
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2228343898
- Cited by
- 201
- References
- 25
- FWCI
- 17.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hunt, P. A., Sathyanarayana, S., Fowler, P. A., & Trasande, L. (2016). Female Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine Disrupting Chemicals in the European Union. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2015-2873
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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