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Cited by 173Ovarian function and disordersSirtuins and Resveratrol in MedicineReproductive Biology and Fertility

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial

Banaszewska, Beata, Wrotyńska-Barczyńska, Joanna, Spaczynski, Robert Z., Pawelczyk, Leszek, Duleba, Antoni J.·2016·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2016-1858
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Abstract

CONTEXT: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism is the central feature of PCOS. Studies on isolated ovarian theca-interstitial cells suggest that resveratrol, a natural polyphenol, reduces androgen production. OBJECTIVE: This study was designed to evaluate endocrine and metabolic effects of resveratrol on PCOS. DESIGN AND SETTING: This was a randomized (1:1) double-blind, placebo-controlled trial that evaluated the effects of resveratrol over a period of 3 months in an academic hospital. PATIENTS AND OTHER PARTICIPANTS: Subjects with PCOS were identified according to the Rotterdam criteria. Thirty-four subjects were enrolled and 30 subjects completed the trial. Evaluations were performed at baseline and repeated after 3 months of treatment. INTERVENTION: Resveratrol (1,500 mg p.o.) or placebo were administered daily. MAIN OUTCOME MEASURE: Primary outcome was the change in the serum total T. RESULTS: Resveratrol treatment led to a significant decrease of total T by 23.1% (P = .01). In parallel, resveratrol induced a 22.2% decrease of dehydroepiandrosterone sulfate (P = .01), a decrease of fasting insulin level by 31.8% (P = .007) and an increase of the Insulin Sensitivity Index (Matsuda and DeFronzo) by 66.3% (P = .04). Levels of gonadotropins, the lipid profile as well as markers of inflammation and endothelial function were not significantly altered. CONCLUSIONS: Resveratrol significantly reduced ovarian and adrenal androgens. This effect may be, at least in part, related to an improvement of insulin sensitivity and a decline of insulin level.

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Metadata

Authors
Banaszewska, B., Wrotyńska-Barczyńska, J., Spaczynski, R. Z., Pawelczyk, L., & Duleba, A. J.
Affiliations
Poznan University of Medical Sciences (PL)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2016-11
Volume
101
Issue
11
Pages
4322-4328
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2016-1858
OpenAlex
W2532986090
Cited by
173
References
35
Citations by year
2026: 21 · 2025: 14 · 2024: 22 · 2023: 23 · 2022: 23 · 2021: 24 · 2020: 16 · 2019: 17 · 2018: 7 · 2017: 6
FWCI
13.29
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
resveratrol, polycystic ovary syndrome, hyperandrogenism, serum total testosterone, dehydroepiandrosterone sulfate, insulin sensitivity, fasting insulin, insulin resistance, insulin-like growth factor I, ovarian androgen production, adrenal androgens, lipid profile, inflammation, endothelial function
MeSH terms
Resveratrol, Adult, Antioxidants, Double-Blind Method, Female, Humans, Insulin, Insulin Resistance, Polycystic Ovary Syndrome, Stilbenes, Testosterone, Outcome Assessment, Health Care, Dehydroepiandrosterone Sulfate

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