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Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial
Abstract
CONTEXT: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism is the central feature of PCOS. Studies on isolated ovarian theca-interstitial cells suggest that resveratrol, a natural polyphenol, reduces androgen production. OBJECTIVE: This study was designed to evaluate endocrine and metabolic effects of resveratrol on PCOS. DESIGN AND SETTING: This was a randomized (1:1) double-blind, placebo-controlled trial that evaluated the effects of resveratrol over a period of 3 months in an academic hospital. PATIENTS AND OTHER PARTICIPANTS: Subjects with PCOS were identified according to the Rotterdam criteria. Thirty-four subjects were enrolled and 30 subjects completed the trial. Evaluations were performed at baseline and repeated after 3 months of treatment. INTERVENTION: Resveratrol (1,500 mg p.o.) or placebo were administered daily. MAIN OUTCOME MEASURE: Primary outcome was the change in the serum total T. RESULTS: Resveratrol treatment led to a significant decrease of total T by 23.1% (P = .01). In parallel, resveratrol induced a 22.2% decrease of dehydroepiandrosterone sulfate (P = .01), a decrease of fasting insulin level by 31.8% (P = .007) and an increase of the Insulin Sensitivity Index (Matsuda and DeFronzo) by 66.3% (P = .04). Levels of gonadotropins, the lipid profile as well as markers of inflammation and endothelial function were not significantly altered. CONCLUSIONS: Resveratrol significantly reduced ovarian and adrenal androgens. This effect may be, at least in part, related to an improvement of insulin sensitivity and a decline of insulin level.
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“In a randomized placebo-controlled trial, treatment with 1500 mg daily of resveratrol significantly decreased testosterone and dehydroepiandrosterone sulfate excess by ~23% in PCOS women over a period of 3 months [138].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [138]
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Cites
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Matsuda, M., & DeFronzo, R. A. (1999) · Diabetes Care · doi:10.2337/diacare.22.9.1462 · Cited by 5,621
Katz, A., Nambi, S. S., Mather, K., Baron, A. D., Follmann, D. A., Sullivan, G., & Quon, M. J. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6661 · Cited by 3,931 · cited 1×
“Evaluation of insulin sensitivity using fasting measures used the method described by Katz et al (22): Quantitative Insulin Sensitivity Check Index (QUICKI) 1/[log(fasting insulin) log (fasting glucose)].”
MethodInsulin Resistance and the Polycystic Ovary Syndrome: Mechanism and Implications for Pathogenesis
Dunaif, A. E. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.6.0318 · Cited by 2,776
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715
March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I. W., Norman, R. J., & Davies, M. J. (2010) · Human Reproduction · doi:10.1093/humrep/dep399 · Cited by 1,799
Asunción, M., Calvo, R. M., Millán, J. L. S., Sancho, J., Ávila, S., & Escobar-Morreale, H. F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6682 · Cited by 1,328
Diamanti‐Kandarakis, E., Kouli, C., Bergiele, A. T., Filandra, F. A., Tsianateli, T. C., Spina, G., Zapanti, E. D., & Bartzis, M. I. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.11.6148 · Cited by 1,107
Wild, R. A., Carmina, E., Diamanti-Kandarakis, E., Dokras, A., Escobar-Morreale, H. F., Futterweit, W., Lobo, R., Norman, R. J., Talbott, E., & Dumesic, D. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2724 · Cited by 1,010
Nelson, V. L., Legro, R. S., Strauss, J. F., & McAllister, J. M. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.6.0311 · Cited by 556
Morphology and Morphogenesis of the Stein-Leventhal Ovary and of So-called “Hyperthecosis”
Hughesdon, P. E. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198202000-00001 · Cited by 429
Chen, S., Zhao, X., Ran, L., Wan, J., Wang, X., Qin, Y., Shu, F., Gao, Y., Yuan, L., Zhang, Q., et al. (2015) · Digestive and Liver Disease · doi:10.1016/j.dld.2014.11.015 · Cited by 319
Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome
Gilling‐Smith, C., Story, H., Rogers, V., & Franks, S. (1997) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1997.2321049.x · Cited by 301
Pilot study of resveratrol in older adults with impaired glucose tolerance
Crandall, J. P., Oram, V., Trandafirescu, G., Reid, M., Kishore, P., Hawkins, M., Cohen, H. W., & Barzilai, N. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr235 · Cited by 281
Kolodziejczyk, B., Dulęba, A. J., Spaczyński, R., & Pawelczyk, L. A. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)00501-x · Cited by 254
Self-citationBergh, C., Carlsson, B., Olsson, J., Selleskog, U., & Hillensjø, T. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55675-1 · Cited by 253
Prevalence of adrenal androgen excess in patients with the polycystic ovary syndrome (PCOS)
Kumar, A., Woods, K. S., Bartolucci, A. A., & Azziz, R. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02256.x · Cited by 238
Morin-Papunen, L. C., Vauhkonen, I., Koivunen, R. M., Ruokonen, A., & Tapanainen, J. S. (2000) · Human Reproduction · doi:10.1093/humrep/15.6.1266 · Cited by 226
Wickenheisser, J. K., Quinn, P. G., Nelson-DeGrave, V. L., Legro, R. S., Strauss, J. F., & McAllister, J. M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6631 · Cited by 192
Faghihzadeh, F., Adibi, P., & Hekmatdoost, A. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002433 · Cited by 188
Insulin Stimulates Androgen Accumulation in Incubations of Human Ovarian Stroma and Theca
Barbieri, R. L., Makris, A., & Ryan, K. J. (1984) · Obstetrics and Gynecology · doi:10.1097/00006250-198409001-00019 · Cited by 175
Inflammatory and endothelial markers in women with polycystic ovary syndrome
Diamanti‐Kandarakis, E., Alexandraki, K., Piperi, C., Protogerou, A. D., Katsikis, I., Paterakis, T., Lekakis, J., & Panidis, D. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01712.x · Cited by 168
Azziz, R., Black, V. Y., Hines, G. A., Fox, L. M., & Boots, L. R. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.7.4948 · Cited by 160
Heebøll, S., Kreuzfeldt, M., Hamilton-Dutoit, S., Kjær Poulsen, M., Stødkilde-Jørgensen, H., Møller, H. J., Jessen, N., Thorsen, K., Kristina Hellberg, Y., Bønløkke Pedersen, S., et al. (2016) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2015.1107620 · Cited by 154
Effects of Simvastatin and Metformin on Polycystic Ovary Syndrome after Six Months of Treatment
Banaszewska, B., Pawelczyk, L. A., Spaczyński, R., & Dulęba, A. J. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0501 · Cited by 110
Self-citationBanaszewska, B., Pawelczyk, L. A., Spaczyński, R., & Dulęba, A. J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1674 · Cited by 89
Self-citationGlintborg, D., Altinok, M. L., Mumm, H., Hermann, A. P., Ravn, P., & Andersen, M. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1135 · Cited by 88
Effects of resveratrol on proliferation and apoptosis in rat ovarian theca-interstitial cells
Wong, D. H., Villanueva, J. A., Cress, A. B., & Duleba, A. J. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq002 · Cited by 76
Panidis, D., Georgopoulos, N. A., Piouka, A., Katsikis, I., Saltamavros, A. D., Decavalas, G., & Diamanti‐Kandarakis, E. (2010) · Gynecological Endocrinology · doi:10.3109/09513590.2010.507283 · Cited by 71
Ortega, I., Villanueva, J. A., Wong, D. H., Cress, A. B., Sokalska, A., Stanley, S. D., & Duleba, A. J. (2012) · Endocrinology · doi:10.1210/en.2012-1385 · Cited by 57
Effects of resveratrol on growth and function of rat ovarian granulosa cells
Ortega, I., Wong, D. H., Villanueva, J. A., Cress, A. B., Sokalska, A., Stanley, S. D., & Dulęba, A. J. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.004 · Cited by 57
Wong, D. H., Villanueva, J. A., Cress, A. B., Sokalska, A., Ortega, I., & Dulęba, A. J. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.08.010 · Cited by 47
Hines, G. A., Smith, E. R., & Azziz, R. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02014-3 · Cited by 41
Villanueva, J. A., Sokalska, A., Cress, A. B., Ortega, I., Bruner‐Tran, K. L., Osteen, K. G., & Dulęba, A. J. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3387 · Cited by 32
Adrenal gland volume assessed by magnetic resonance imaging in women with polycystic ovary syndrome
Unlu, E., Unlu, B. S., Yıldız, Y., Acay, M. B., Kaçar, E., Turamanlar, O., Tulmaç, Ö. B., Seven, A., & Özuğuz, U. (2015) · Diagnostic and Interventional Imaging · doi:10.1016/j.diii.2015.02.004 · Cited by 12
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Health benefits of resveratrol: Evidence from clinical studies
Singh, A. P., Singh, R., Verma, S. S., Rai, V., Kaschula, C. H., Maiti, P., & Gupta, S. C. (2019) · Medicinal Research Reviews · doi:10.1002/med.21565 · Cited by 523
Tatone, C., Emidio, G. D., Barbonetti, A., Carta, G., Luciano, A. M., Falone, S., & Amicarelli, F. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy003 · Cited by 296
Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases
Mirabelli, M., Chiefari, E., Arcidiacono, B., Corigliano, D. M., Brunetti, F. S., Maggisano, V., Russo, D., Foti, D. P., & Brunetti, A. (2020) · Nutrients · doi:10.3390/nu12041066 · Cited by 272
“In a randomized placebo-controlled trial, treatment with 1500 mg daily of resveratrol significantly decreased testosterone and dehydroepiandrosterone sulfate excess by ~23% in PCOS women over a period of 3 months [138].”
BackgroundMethodInfluentialAdvances in phytochemical delivery systems for improved anticancer activity
Lagoa, R., Silva, J. S., Rodrigues, J. R., & Bishayee, A. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.04.004 · Cited by 215
Brown, K., Theofanous, D., Britton, R. G., Aburido, G., Pepper, C., Undru, S. S., & Howells, L. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020747 · Cited by 209
Metadata
- Authors
- Banaszewska, B., Wrotyńska-Barczyńska, J., Spaczynski, R. Z., Pawelczyk, L., & Duleba, A. J.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2016-11
- Volume
- 101
- Issue
- 11
- Pages
- 4322-4328
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2532986090
- Cited by
- 173
- References
- 35
- Citations by year
- 2026: 21 · 2025: 14 · 2024: 22 · 2023: 23 · 2022: 23 · 2021: 24 · 2020: 16 · 2019: 17 · 2018: 7 · 2017: 6
- FWCI
- 13.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Keywords
- resveratrol, polycystic ovary syndrome, hyperandrogenism, serum total testosterone, dehydroepiandrosterone sulfate, insulin sensitivity, fasting insulin, insulin resistance, insulin-like growth factor I, ovarian androgen production, adrenal androgens, lipid profile, inflammation, endothelial function
- MeSH terms
- Resveratrol, Adult, Antioxidants, Double-Blind Method, Female, Humans, Insulin, Insulin Resistance, Polycystic Ovary Syndrome, Stilbenes, Testosterone, Outcome Assessment, Health Care, Dehydroepiandrosterone Sulfate
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