The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dehydroepiandrosterone Sulfate: A Biomarker of Primate Aging Slowed by Calorie Restriction
Open accessAbstract
The adrenal steroids, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), have attracted attention for their possible antiaging effects. DHEAS levels in humans decline markedly with age, suggesting the potential importance of this parameter as a biomarker of aging. Here we report that, as seen in humans, male and female rhesus monkeys exhibit a steady, age-related decline in serum DHEAS. This decline meets several criteria for a biomarker of aging, including cross-sectional and longitudinal linear decreases with age and significant stability of individual differences over time. In addition, the proportional age-related loss of DHEAS in rhesus monkeys is over twice the rate of decline observed in humans. Most important is the finding that, in rhesus monkeys, calorie restriction, which extends life span and retards aging in laboratory rodents, slows the postmaturational decline in serum DHEAS levels. This represents the first evidence that this nutritional intervention has the potential to alter aspects of postmaturational aging in a long-lived species.
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Cites
A prospective study of dehydroepiandrosterone sulfate, mortality and cardiovascular disease.
Barrett-Connor, E., Khaw, K.-T., & Yen, S. S. C. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612113152405 · Cited by 681
Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men
Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R., & Baldwin, H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400863 · Cited by 417
Inhibition of tumor development by dehydroepiandrosterone and related steroids.
Schwartz, A. G., Pashko, L., & Whitcomb, J. M. (1986) · Toxicologic Pathology · doi:10.1177/019262338601400312 · Cited by 101
Cited by
Premature Adrenarche—Normal Variant or Forerunner of Adult Disease?*
Ibáñez, L., DiMartino-Nardi, J., Potau, N., & Saenger, P. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0416 · Cited by 416
WILLCOX, B. J., WILLCOX, D. C., TODORIKI, H., FUJIYOSHI, A., YANO, K., HE, Q., CURB, J. D., & SUZUKI, M. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1396.037 · Cited by 370
T cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in Bioscience · doi:10.2741/a831 · Cited by 369
Pawelec, G. (1998) · Frontiers in Bioscience · doi:10.2741/a266 · Cited by 357
Aging in Rhesus Monkeys: Relevance to Human Health Interventions
Roth, G. S., Mattison, J. A., Ottinger, M. A., Chachich, M. E., Lane, M. A., & Ingram, D. K. (2004) · Science · doi:10.1126/science.1102541 · Cited by 353
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Metadata
- Authors
- Lane, M. A.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-07-01
- Volume
- 82
- Issue
- 7
- Pages
- 2093-2096
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2133835465
- Cited by
- 176
- References
- 3
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lane, M. A. (1997). Dehydroepiandrosterone Sulfate: A Biomarker of Primate Aging Slowed by Calorie Restriction. Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.82.7.2093
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