Leptin Levels, -Cell Function, and Insulin Sensitivity in Families with Congenital and Acquired Generalized Lipoatropic Diabetes
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Generalized lipodystrophy in rodents and patients constitutes a severe hypoleptinemic state.
“generalized lipodystrophy in rodents and patients constituted a severe hypoleptinemic state (2,3).”
From Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy (2005) · cites this paper as [2]
Cited by
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Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy
Javor, E. D., Cochran, E. K., Musso, C., Young, J. R., DePaoli, A. M., & Gorden, P. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1994 · Cited by 226 · see citing works
“This formed the basis for understanding that adipose tissue is an endocrine organ and that generalized lipodystrophy in rodents and patients constituted a severe hypoleptinemic state (2,3).”
BackgroundGenetic disorders of adipose tissue development, differentiation, and death.
Agarwal, A. K., & Garg, A. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115715 · Cited by 150 · see citing works
Lipodystrophies: rare disorders causing metabolic syndrome
Garg, A., & Misra, A. (2004) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2004.03.003 · Cited by 138 · see citing works
Simha, V., Szczepaniak, L. S., Wagner, A. J., DePaoli, A. M., & Garg, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.30 · Cited by 123 · see citing works
20 YEARS OF LEPTIN: Role of leptin in human reproductive disorders
Chou, S. H.-H., & Mantzoros, C. S. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0245 · Cited by 107 · see citing works
Clinical perspectives on HIV-associated lipodystrophy syndrome: an update
Shevitz, A., WANKE, C. A., Falutz, J., & Kotler, D. P. (2001) · AIDS · doi:10.1097/00002030-200110190-00003 · Cited by 97 · see citing works
Nakayama, H., Otabe, S., Ueno, T., Hirota, N., Yuan, X., Fukutani, T., Hashinaga, T., Wada, N., & Yamada, K. (2007) · Metabolism · doi:10.1016/j.metabol.2006.11.004 · Cited by 79 · see citing works
Leptin as a Modulator of Neuroendocrine Function in Humans
Khan, S. M., Hamnvik, O. R., Brinkoetter, M. T., & Mantzoros, C. S. (2012) · Yonsei Medical Journal · doi:10.3349/ymj.2012.53.4.671 · Cited by 67 · see citing works
Larcher, F., Río, M. D., Serrano, F., Segovia, J. C., Ramı́rez, Á., Meana, Á., Page, A., Abad, J. L., GonzáLez, M. A., Bueren, J. A., et al. (2001) · The FASEB Journal · doi:10.1096/fj.01-0082com · Cited by 67 · see citing works
“It has become apparent that a group of patients suffering from some forms of lipodystrophy show reduced leptin levels (12).”
Park, S., Ahn, I. S., & Kim, D. S. (2010) · Life Sciences · doi:10.1016/j.lfs.2010.03.021 · Cited by 46 · see citing works
Clinical and molecular aspects of Berardinelli–Seip Congenital Lipodystrophy (BSCL)
Gomes, K. B., Pardini, V. C., & Fernandes, A. P. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.12.032 · Cited by 43 · see citing works
Self-citationReduced Adiposity in ob/ob Mice following Total Body Irradiation and Bone Marrow Transplantation
Ablamunits, V. G., Weisberg, S. P., Lemieux, J. E., Combs, T. P., & Klebanov, S. (2007) · Obesity · doi:10.1038/oby.2007.170 · Cited by 41 · see citing works
“An extreme paucity of adipose tissue in humans with generalized lipodystrophy is also associated with IR and hyperglycemia (7).”
BackgroundAdipocyte biology and adipocytokines
Haque, W. A., & Garg, A. (2004) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2004.01.007 · Cited by 27 · see citing works
Gomes, K. B., Pardini, V. C., Ferreira, A. C. D. S., & Fernandes, A. P. (2005) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-005-0038-5 · Cited by 25 · see citing works
Self-citationVictoria, B., Cabezas-Agrícola, J. M., González‐Méndez, B., et al. (2010) · Diabetic Medicine · doi:10.1111/j.1464-5491.2010.03052.x · Cited by 24 · see citing works
The molecular basis of genetic lipodystrophies
Bhayana, S., & Hegele, R. A. (2002) · Clinical Biochemistry · doi:10.1016/s0009-9120(02)00297-7 · Cited by 23 · see citing works
Palacios, R., Santos, J. S., Ruiz, J., González, M., & Márquez, M. (2003) · AIDS · doi:10.1097/00002030-200304110-00025 · Cited by 17 · see citing works
Syndromes of Severe Insulin Resistance and/or Lipodystrophy
Semple, R. K., Savage, D. B., Halsall, D. J., & O’Rahilly, S. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374430-2.00004-3 · Cited by 14 · see citing works
Lipoatrophic Diabetes in an Elderly Woman: Clinical Course and Serum Adipocytokine Concentrations
Iglesias, P., Fidalgo, P. A., Codoceo, R., & Díez, J. J. (2004) · Endocrine Journal · doi:10.1507/endocrj.51.279 · Cited by 13 · see citing works
“The acquired form, initially reported by Ziegler in 1928 [5] and, subsequently, described in detail by Lawrence in 1946 (Lawrence syndrome) [4], is usually sporadic although some familial cases have been reported [6].”
BackgroundA Monoclonal Antibody Against Leptin
Mahmoudian, J., Jeddi‐Tehrani, M., Bayat, A. A., Mahmoudi, A. R., Vojgani, Y., Tavangar, B., Hadavi, R., & Zarei, S. (2012) · Hybridoma · doi:10.1089/hyb.2012.0045 · Cited by 12 · see citing works
“The former includes rare cases of congenital leptin deficiency due to mutations of leptin-related genes and congenital lipoatrophy due to lack of available fat to produce leptin.((14,15)) On the other hand, the latter involves prevalent conditions such as anorexia nervosa and exercise-induced hypothalamic amenorrhea.”
BackgroundFardet, L., Vigouroux, C., & Capeau, J. (2012) · La Revue de Médecine Interne · doi:10.1016/j.revmed.2012.11.008 · Cited by 12 · see citing works
Functional human to mouse adipose tissue xenotransplantation
Ablamunits, V. G., Klebanov, S., Giese, S. Y., & Herold, K. C. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0201 · Cited by 11 · see citing works
Berardinelli–Seip syndrome: highlight of treatment challenge
Ferraria, N., Pedrosa, C., Amaral, D., & Lopes, L. (2013) · BMJ Case Reports · doi:10.1136/bcr-2012-007734 · Cited by 8 · see citing works
Lipodistrofias: bases moleculares y manifestaciones clínicas
Vilar, D. A. (2003) · Endocrinología y Nutrición · doi:10.1016/s1575-0922(03)74513-6 · Cited by 3 · see citing works
“Otras alteraciones metabólicas son la diabetes mellitus, el descenso del colesterol HDL, la resistencia a la insulina, la hiperin-sulinemia y la hipoleptinemia 20 .”
Leptin and Reproduction in the Male
Lado‐Abeal, J., & Norman, R. L. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0157-2_8 · Cited by 3 · see citing works
Jimenez, F. F., Torre‐Cisneros, J., & Jiménez, F. P. (2002) · Medicina Clínica · doi:10.1016/s0025-7753(02)73425-8 · Cited by 1 · see citing works
The HAART-Induced Metabolic Syndrome
Tsiodras, S., Kelesidis, T., & Mantzoros, C. S. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-985-1_23 · Cited by 1 · see citing works
Lipoatrophic Diabetes Mellitus
Oral, E. A., & Moran, S. A. (2003) · Springer eBooks · doi:10.1007/978-1-4615-0507-5_8
Glykogenspeichererkrankungen, Lipodystrophien und andere Fettgewebserkrankungen
Steinmetz, A., & Schmidt, H. (2006) · Springer eBooks · doi:10.1007/3-540-27385-9_42
Effect of Leptin on Fatless Mice
Shimomura, I. (2002) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-18999-9_9
Other Acquired Disorders of Subcutaneous Fat
Chen, A. Y. ‐., & Garg, A. (2016) · doi:10.1002/9781118441213.rtd0101
Linder, J. E., Usmani, A., Miteva, M., Ricordi, C., & Romanelli, P. (2010) · Springer eBooks · doi:10.1007/978-1-60761-181-3_9
Glykogenspeichererkrankungen, Lipodystrophien und andere Fettgewebserkrankungen
Steinmetz, A., & Schmidt, H. (2007) · Springer eBooks · doi:10.1007/978-3-540-48554-4_42
Non‐Inflammatory Disorders of Subcutaneous Fat
Lee, G. L., Garg, A., & Chen, A. Y. ‐. (2024) · doi:10.1002/9781119709268.rook098
- Authors
- Pardini, V. C.
- Corresponding author
- Pardini, V. C.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1998-02-01
- Volume
- 83
- Issue
- 2
- Pages
- 503-508
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W4232598673
- Cited by
- 37
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- leptin, beta-cell function, insulin sensitivity, lipoatrophy, familial diabetes
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