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The Effects of 10 Years of Recombinant Human Growth Hormone (GH) in Adult GH-Deficient Patients
Abstract
The long term effects of GH replacement in adult GH-deficient (GHD) patients have not yet been clarified. We studied 21 GHD adults who originally took part in a randomized, double blind, placebo-controlled trial of GH treatment in 1987. After completion of that trial, 10 patients received continuous GH replacement for the subsequent 10 yr, whereas 11 did not. A group of 11 age- and sex-matched normal controls were also studied in 1987 and 1997. Lean body mass, as assessed by total body potassium measurement and computed tomography scanning of the dominant thigh, increased in the GH-treated group (P < 0.01 for both) only (P < 0.05 between groups for total body potassium). Low density lipoprotein cholesterol decreased in the GH-treated group (P < 0.05) only. Carotid intima media thickness was significantly greater (P < 0.05) in the untreated group than in the GH-treated group. Assessment of psychological well-being using the Nottingham Health Profile revealed improvement in overall score, energy levels, and emotional reaction in the GH-treated group compared with those in the untreated group (P < 0.02). In conclusion, GH treatment for 10 yr in GHD adults resulted in increased lean body and muscle mass, a less atherogenic lipid profile, reduced carotid intima media thickness, and improved psychological well-being.
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Premature mortality due to cardiovascular disease in hypopituitarism
Rosén, T., & Bengtsson, B.-Å. (1990) · The Lancet · doi:10.1016/0140-6736(90)91812-o · Cited by 1,402
The effect of hypopituitarism on life expectancy.
Bates, A. S., Van't Hoff, W., Jones, P. J., & Clayton, R. N. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772595 · Cited by 475
Cited by
Molitch, M. E., Clemmons, D. R., Malozowski, S., Merriam, G. R., & Vance, M. L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0179 · Cited by 1,047
Kavey, R.-E. W., Allada, V., Daniels, S. R., Hayman, L. L., McCrindle, B. W., Newburger, J. W., Parekh, R. S., & Steinberger, J. (2006) · Circulation · doi:10.1161/circulationaha.106.179568 · Cited by 707
Evolutionary medicine: from dwarf model systems to healthy centenarians?
Longo, V. D., & Finch, C. E. (2003) · Science · doi:10.1126/science.1077991 · Cited by 575
Mortality in Patients with Pituitary Disease
Sherlock, M., Ayuk, J., Tomlinson, J. W., Toogood, A. A., Aragon-Alonso, A., Sheppard, M. C., Bates, A. S., & Stewart, P. M. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0033 · Cited by 392
Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain
Regal, M., Páramo, C., Sierra, J. M., & García‐Mayor, R. V. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01406.x · Cited by 354
Perrini, S., Laviola, L., Carreira, M. C., Cignarelli, A., Natalicchio, A., & Giorgino, F. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0431 · Cited by 317
Yuen, K. C. J., Biller, B. M. K., Radovick, S., Carmichael, J. D., Jasim, S., Pantalone, K. M., & Hoffman, A. R. (2019) · Endocrine Practice · doi:10.4158/gl-2019-0405 · Cited by 298
Consensus guidelines on screening for hypopituitarism following traumatic brain injury
Ghigo, E., Masel, B., Aimaretti, G., Léon-Carrión, J., Casanueva, F. F., Dominguez-Morales, M. R., Elovic, E., Perrone, K., Stalla, G., Thompson, C., et al. (2005) · Brain Injury · doi:10.1080/02699050400025315 · Cited by 261
Effects of growth hormone on glucose metabolism and insulin resistance in human
Kim, S.-H., & Park, M.-J. (2017) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2017.22.3.145 · Cited by 181
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
Kickboxing sport as a new cause of traumatic brain injury-mediated hypopituitarism
Tanriverdi, F., Unluhizarci, K., Coksevim, B., Selcuklu, A., Casanueva, F. F., & Kelestimur, F. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02737.x · Cited by 130
Slawik, M., Klawitter, B., Meiser, E., Schories, M., Zwermann, O., Borm, K., Peper, M., Lubrich, B., Hug, M. J., Nauck, M., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0297 · Cited by 113
Le Grevès, M., Zhou, Q., Berg, M., Le Grevès, P., Fhölenhag, K., Meyerson, B., & Nyberg, F. (2006) · Experimental Brain Research · doi:10.1007/s00221-006-0438-2 · Cited by 92
Ten years of growth hormone (GH) replacement normalizes muscle strength in GH-deficient adults
Götherström, G., Elbornsson, M., Stibrant-Sunnerhagen, K., Bengtsson, B.-A., Johannsson, G., & Svensson, J. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1538 · Cited by 85
Cardiovascular risk factors in hypopituitary GH-deficient adults
Verhelst, J., & Abs, R. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0291 · Cited by 70
van Thiel, S. W., Romijn, J. A., Pereira, A. M., Biermasz, N. R., Roelfsema, F., van Hemert, A., Ballieux, B., & Smit, J. W. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1802 · Cited by 66
Filipsson, H., & Johannsson, G. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0319 · Cited by 50
Ragnarsson, O., Mattsson, A. F., Monson, J. P., Filipsson Nyström, H., Åkerblad, A.-C., Kołtowska-Häggström, M., & Johannsson, G. (2014) · European Journal of Endocrinology · doi:10.1530/eje-14-0397 · Cited by 46
Berg, C., Meinel, T., Lahner, H., Mann, K., & Petersenn, S. (2010) · European Journal of Endocrinology · doi:10.1530/eje-09-0997 · Cited by 36
van Varsseveld, N. C., van Bunderen, C. C., Franken, A. A. M., Koppeschaar, H. P. F., van der Lely, A. J., & Drent, M. L. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-1764 · Cited by 26
The impact of traumatic brain injury on pituitary function
Sundaram, N. K., Geer, E. B., & Greenwald, B. D. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.05.003 · Cited by 22
Allo Miguel, G., Serraclara Plá, A., Partida Muñoz, M. L., Martínez Díaz-Guerra, G., & Hawkins, F. (2016) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018816643908 · Cited by 22
Tanriverdi, F., Karaca, Z., Unluhizarci, K., & Kelestimur, F. (2014) · Endocrine · doi:10.1007/s12020-014-0276-0 · Cited by 20
Birzniece, V., & Ho, K. K. Y. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0426 · Cited by 8
Metadata
- Authors
- Gibney, J.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1999-08-01
- Volume
- 84
- Issue
- 8
- Pages
- 2596-2602
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2169611533
- Cited by
- 324
- References
- 2
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- closed
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