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Cited by 458Cardiovascular Health and Disease PreventionHormonal and reproductive studiesHIV-related health complications and treatments

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

The Effects of Induced Hypogonadism on Arterial Stiffness, Body Composition, and Metabolic Parameters in Males with Prostate Cancer

Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., Davies, J. S.·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.9.7851
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Abstract

Sex hormones appear to play a pivotal role in determining cardiovascular risk. Androgen deprivation therapy for males with prostate cancer results in a hypogonadal state that may have important, but as yet undetermined, effects on the vasculature. We studied the effects of androgen deprivation therapy on large artery stiffness in 22 prostate cancer patients (mean age, 67 +/- 8 yr) over a 6-month period. Arterial stiffness was assessed using pulse-wave analysis, a technique that measures peripheral arterial pressure waveforms and generates corresponding central aortic waveforms. This allows determination of the augmentation of central pressure resulting from wave reflection and the augmentation index, a measure of large artery stiffness. Body compositional changes were assessed using bioelectrical impedance analysis. Fasting lipids, glucose, insulin, testosterone, and estradiol were measured. After a 3-month treatment period, the augmentation index increased from 24 +/- 6% (mean +/- SD) at baseline to 29 +/- 9% (P = 0.003) despite no change in peripheral blood pressure. Timing of wave reflection was reduced from 137 +/- 7 to 129 +/- 10 msec (P = 0.003). Fat mass increased from 20.2 +/- 9.4 to 21.9 +/- 9.6 kg (P = 0.008), whereas lean body mass decreased from 63.2 +/- 6.8 to 61.5 +/- 6.0 kg (P = 0.016). There were no changes in lipids or glucose during treatment. Median serum insulin rose from 11.8 (range, 5.6-49.1) to 15.1 (range, 7.3-83.2) mU/liter at 1 month (P = 0.021) and to 19.3 (range, 0-85.0 mU/liter by 3 months (P = 0.020). There was a correlation between the changes in fat mass and insulin concentration over the 3-month period (r = 0.56; P = 0.013). In a subgroup of patients whose treatment was discontinued after 3 months, the augmentation index decreased from 31 +/- 7% at 3 months to 29 +/- 5% by 6 months, in contrast to patients receiving continuing treatment in whom the augmentation index remained elevated at 6 months compared with baseline (P = 0.043). These data indicate that induced hypogonadism in males with prostate cancer results in a rise in the augmentation of central arterial pressure, suggesting large artery stiffening. Adverse body compositional changes associated with rising insulin concentrations suggest reduced insulin sensitivity. These adverse hemodynamic and metabolic effects may increase cardiovascular risk in this patient group.

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Crossref · 10.1210/jcem.86.9.7851

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Metadata

Authors
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S.
Affiliations
  • University Hospital of Wales (GB)
  • Medical Research Council (GB)
  • Cardiff University (GB)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-09
Volume
86
Issue
9
Pages
4261-4267
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.9.7851
OpenAlex
W2085368059
Semantic Scholar
6b7acf91f76d8e1b94e1d7f3812ad05368f47c3d
Cited by
458
References
58
Citations by year
2026: 5 · 2025: 9 · 2024: 12 · 2023: 7 · 2022: 14 · 2021: 5 · 2020: 15 · 2019: 17 · 2018: 14 · 2017: 15 · 2016: 17 · 2015: 25 · 2014: 23 · 2013: 20 · 2012: 40
FWCI
8.70
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
Keywords
androgen deprivation therapy, prostate cancer, hypogonadism, arterial stiffness, augmentation index, pulse wave analysis, body composition, fat mass, lean body mass, insulin, testosterone, estradiol, cardiovascular risk, vascular system, metabolic parameters, lipid profile, glucose, treatment discontinuation, older men, sex hormones, vascular protection
MeSH terms
Adipose Tissue, Aged, Arteries, Body Composition, Hemodynamics, Humans, Hypogonadism, Insulin, Insulin Resistance, Gonadotropin-Releasing Hormone, Lipoproteins, Male, Manometry, Middle Aged, Prostatic Neoplasms, Prostate-Specific Antigen

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CoChat. (2026). Citation check: The Effects of Induced Hypogonadism on Arterial Stiffness, Body Composition, and Metabolic Parameters in Males with Prostate Cancer. https://app.cochat.ai/papers/10.1210/jcem.86.9.7851
The paper
Smith, J. C., Bennett, S., Evans, L. M., Kynaston, H. G., Parmar, M., Mason, M. D., Cockcroft, J. R., Scanlon, M. F., & Davies, J. S. (2001). The Effects of Induced Hypogonadism on Arterial Stiffness, Body Composition, and Metabolic Parameters in Males with Prostate Cancer. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.86.9.7851

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.