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Cited by 144Bone health and osteoporosis researchBone Metabolism and DiseasesSmoking Behavior and Cessation

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Increased Bone Resorption in Moderate Smokers with Low Body Weight: The Minos Study

Szulc, P.·2002·Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.87.2.666
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Abstract

Tobacco was found to be a risk factor for osteoporosis, mainly in postmenopausal women. We studied the effect of smoking on bone mineral density (BMD) and bone turnover in a cohort of 719 men, aged 51–85 yr, composed of 83 current smokers, 405 former smokers, and 231 men who never smoked. Most current and former smokers were moderate smokers (median, 10 cigarettes/d). Current smokers were younger, thinner, and drank more coffee and more alcoholic beverages. After adjustment for age, body weight, alcohol intake, and caffeine intake, current and former smokers had similar BMD, except at the forearm. Former smokers had lower BMD compared with never-smokers at most skeletal sites. Men who had smoked more than 7120 packs (third quartile) had lower BMD of total hip (P < 0.01) and distal forearm (P = 0.03) compared with men in the 2 lower tertiles. In the 3 groups, levels of bone formation markers did not differ. After adjustment for confounding variables, levels of urinary markers of bone resorption (β-isomerized C-terminal telopeptide, free and total deoxypyridinoline) were higher in the current smokers than in former smokers and never-smokers. Concentrations of T, total 17β-E2, and androstenedione were higher, whereas that of 25-hydroxyvitamin D was lower, in current smokers. When men were divided according to tertiles of body weight, increased bone resorption, decreased BMD and biochemical indexes of secondary hyperparathyroidism were observed in current smokers in the lowest te…

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Crossref · 10.1210/jc.87.2.666

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Metadata

Authors
Szulc, P.
Affiliations
Inserm (FR)
ORCID
Szulc, P.
Venue
Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2002-02-01
Volume
87
Issue
2
Pages
666-674
ISSN
0021-972X (ISSN-L)
DOI
10.1210/jc.87.2.666
OpenAlex
W2003904705
Cited by
144
References
68
Citations by year
2026: 2 · 2025: 4 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 9 · 2012: 8
FWCI
5.80
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
smoking, bone resorption, bone mineral density, men, underweight, former smokers, bone turnover, secondary hyperparathyroidism, 25-hydroxyvitamin D, vertebral deformity, osteoporosis risk factors, C-terminal telopeptide, deoxypyridinoline, androstenedione, testosterone, estradiol
MeSH terms
Aged, Aged, 80 and over, Body Weight, Bone Resorption, Hormones, Humans, Hyperparathyroidism, Secondary, Male, Middle Aged, Smoking, Spinal Diseases, Vitamin D, Cohort Studies, Biomarkers, Bone Density, Prevalence, Bone Remodeling

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