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Cited by 532

The DOI matches its Crossref record.

Testosterone Secretion and Metabolism in Male Senescence

VERMEULEN, A., RUBENS, R., VERDONCK, L.·1972·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-34-4-730
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Abstract

The influence of aging on plasma testosterone levels and testosterone metabolism in males was studied. It was observed that plasma testosterone levels and the apparent free plasma testosterone concentration (AFTC) remain within the same range from adolescence until the age of 50 yr, but that from the 6th decade on, the mean plasma levels decrease rather rapidly, with however a wide range of individual values. As the metabolic clearance rate (MCR) decreases in male senescence, the net result is an important decrease in the testosterone blood production rate. Within the group of subjects studied, a statistically significant correlation between the free testosterone fraction and the MCR was found. It was observed that testosterone metabolism in male senescence is characterized by a relative decrease of the formation of androstanediols, with a relative increase of 5β over 5α metabolites;moreover a statistically significant correlation between the formation of 5α-androstane-3α,17β-diol and the free testosterone fraction was found. As the latter metabolite is largely formed in peripheral target tissues, this suggests that testosterone metabolism by target tissues becomes more important with increasing free T fraction and indirectly, that only free testosterone can be taken up by target tissues.

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Metadata

Authors
VERMEULEN, A., RUBENS, R., & VERDONCK, L.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1972-04
Volume
34
Issue
4
Pages
730-735
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-34-4-730
OpenAlex
W2076739340
Cited by
532
References
0
FWCI
17.67
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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